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Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance

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Abstract

Inadequate minerals intake, as well as disruption of some metabolic processes in which microelements are cofactors, are suggested to lead to the development of hypertension. The role of minerals in the pathogenesis of hypertension still remains to be explained. In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and glucose levels. Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the study. Blood pressure, BMI, and insulin resistance were recorded in all subjects. Levels of lipids, glucose, sodium and potassium, iron, copper, zinc, magnesium, and calcium were assessed in serum. Iron, copper, zinc, magnesium, and calcium were assessed in hair. Dietary intake of the analyzed minerals was estimated. We found distinctly higher concentrations of serum iron and serum and hair calcium as well as markedly lower levels of hair zinc in the hypertensive subjects. The study group manifested also significantly lower daily intake of calcium, magnesium, and iron. We observed a relationship between the concentrations of iron, zinc, and copper in serum and hair and high and low range of cholesterol, triglycerides, and glucose serum levels in the studied patients. Moreover, this study demonstrated significant correlation between serum and hair concentrations of selected minerals and their dietary intake and levels of serum lipids and glucose and blood pressure in the study and the control groups. The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper, zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance.

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Abbreviations

TChol:

Total cholesterol

TG:

Triglycerides

LDL:

Low-density lipoproteins

HDL:

High-density lipoproteins

GLU:

Glucose

BP:

Blood pressure

SBP:

Systolic blood pressure

DSB:

Diastolic blood pressure

BMI:

Body mass index

IR:

Insulin resistance

RDA:

Recommended dietary allowance

W:

Women

M:

Men

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Authors and Affiliations

  1. Department of Human Nutrition and Hygiene, Life Sciences University in Poznan, Wojska Polskiego 31, PL 60-624, Poznan, Poland

    Joanna Suliburska & Zbigniew Krejpcio

  2. Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego 84, PL 60-569, Poznan, Poland

    Paweł Bogdański & Danuta Pupek-Musialik

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  1. Joanna Suliburska
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  2. Paweł Bogdański
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  3. Danuta Pupek-Musialik
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  4. Zbigniew Krejpcio
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Correspondence to Joanna Suliburska.

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Suliburska, J., Bogdański, P., Pupek-Musialik, D. et al. Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance. Biol Trace Elem Res 139, 137–150 (2011). https://doi.org/10.1007/s12011-010-8650-0

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