Abstract
Some of the rare earth elements such as Sc are believed to be non-toxic and, at present, are widely utilized for the replacement of toxic heavy metals in technological applications, but they are not entirely free of toxicity, with hidden potential health risks. In this animal experiment, we report the urinary scandium (Sc) excretion rate and nephrotoxiciy in male Wistar rats. For this purpose, the rats were given a single dose of a solution of scandium chloride by intraperitoneal injection. The Sc excretion (U-Sc) was determined in 24-h urine samples by inductively coupled plasma–argon emission spectrometry along with the Sc nephrotoxicity, urine volume (UV), creatinine (Crt), β-2-microglobulin (β2-MG) and N-acetyl-β-d-glucosaminidase (NAG). A dose-dependent Sc excretion of 0.0063% (r = 0.97) via 24-h urine was confirmed. The administration of Sc induced a significant decrease of UV and Crt and a significant increase of NAG and β2-MG. These results suggest that U-Sc can be a useful tool for monitoring Sc exposure. The formation of Sc colloidal conjugates that deposit in glomeruli may be the cause of a reduction of the glomerular filtration rate. We propose that the analytical method and results described in this study will be of great importance for future toxicological studies on Sc exposure.
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V.S. Sastri, J.C. Bünzli, J.R. Perumareddi, V. Ramachandra Rao, G.V.S. Rayudu, Modern Aspects of Rare Earths and their Complexes, Elsevier Science, Amsterdam (2003).
A.M. Gillespie Jr., Manual of Spectrofluorometric and Spectrophotometric Derivative Experiments; Spi edition, CRC, Boca Raton, FL (1993).
K. Bernot, L. Bogani, A. Caneschi, D. Gatteschi, R. Sessoli A family of rare-earth-based single chain magnets: playing with anisotropy. J Am Chem Soc. 128, 7947–56 (2006).
J. Qiu and A. Makishima Rare-earth containing nanocrystal precipitation and up-conversion luminescence in oxyfluoride glasses. J Nanosci Nanotechnol. 5, 1541–5 (2005).
Research Studies-Business Communications, Inc., Global Rare Earth market forecast to reach nearly $2 billion by 2007, Business Communications Company, Wellesley, MA (2003).
L. S. Toropova, D. G. Eskin, M. L. Kharakterova, T. V. Dobatkina Advanced Aluminum Alloys Containing Scandium: Structure and Properties, Taylor & Francis, London (1998).
W. H. Wells Jr, and V. L. Wells, The Lanthanides, Rare Earth Metals, in Patty’s Toxicology, Vol 3, by E. Bingham, B. Cohrssen, C. H. Powell, ed., Wiley-Interscience, 5th edition, Hoboken, NJ, pp432–433 (2000).
K. Hutton, Chemistry (Trends in Science), Routledge, Oxford (2001).
M. Tamada Recovery of rare metals from hot-spring water (in Japanese) Isotope News 630, 2–3 (2006).
M. Tamada Collection of significant metals with graft adsorbent; Necessary security of nonproduced significant metals in Japan Denki Hyoron 93, 54–58 (2008).
S. D. Barrett and S. S. Dhesi, The Structure of Rare-Earth Metal Surfaces, Imperial College Press, London (2001).
W. Zhu, S. Xu, P. Shao, H. Zhang, D. Wu, W. Yang, J. Feng, L. Feng, Investigation on liver function among population in high background of rare earth area in South China. Biol Trace Elem Res. 104, 1–8, (2005).
H. Zhang, J. Feng, W. Zhu, C. Liu, D. Wu, W. Yang, J. Gu, Rare-earth element distribution characteristics of biological chains in rare-earth element-high background regions and their implications. Biol Trace Elem Res. 73, 19–27, (2000).
H. Zhang, J. Feng, W. Zhu, C. Liu, S. Xu, P. Shao, D. Wu, W. Yang, J. Gu, Chronic toxicity of rare-earth elements on human beings: implications of blood biochemical indices in REE-high regions, South Jiangxi. Biol Trace Elem Res. 73, 1–17, (2000).
W. Zhu, S. Xu, P. Shao, H. Zhang, D. Wu, W. Yang, J. Feng, Bioelectrical activity of the central nervous system among populations in a rare earth element area. Biol Trace Elem Res. 57, 71–77, (1997).
W. Zhu, S. Xu, D. Wu, P. Shao, W. Yang, H. Zhang, J. Feng, Investigation on arteriosclerosis among population in a rare earth area in south China. Biol Trace Elem Res. 59, 93–98, (1997).
T.J. Haley, N. Komasu, L. Navis, J. Cawthorne, H.C. Upham, The Pharmacology and Toxicology of Scandium Chloride. Technical Report, California. Univ., Los Angeles. School of Medicine. Lab. of Nuclear Medicine and Radiation Biology, CA, USA (1962).
E. H. Borai, M. A. Eid, H.F. Aly, Determination of REEs distribution in monazite and xenotime minerals by ion chromatography and ICP-AES. Anal Bioanal Chem. 372, 537–541, (2002). 372(4):537–41.
Q. Bian, S. Peng, B. He, Z. Zhong, Direct determination of rare earth elements in rare earth chloride and light rare earth oxide by ICP-AES. Guang Pu Xue Yu Guang Pu Fen Xi. 20, 357–360 (2000).
M. Chiba, A. Shinohara, M. Saiki, Y. Inaba, Comparative study of methods for determining lanthanide elements in biological materials by using NAA, HPLC postcolumn reaction, and ICP-MS. Biol Trace Elem Res. 43–45, 561–569 (1994).
P. R. Silva, J. G. Dorea, G. R. Boaventura, Multielement determination in small samples of human milk by inductively coupled plasma atomic emission spectrometry. Biol Trace Elem Res. 59, 57–62 (1997).
E. Sabbioni, G. R. Nicolaou, R. Pietra, E. Beccaloni, E. Coni, A. Alimonti, S. Caroli, Inductively coupled atomic emission spectrometry and neutron activation analysis for the determination of element reference values in human lung tissue. Biol Trace Elem Res. 26–27, 757–768 (1990).
E. H. Borai, M. A. Eid, H. F. Aly, Determination of REEs distribution in monazite and xenotime minerals by ion chromatography and ICP-AES. Anal Bioanal Chem. 372, 537–541 (2002).
K. Usuda, K. Kono, Y. Orita, T. Dote, K. Iguchi, H. Nishiura, M. Tominaga, T. Tagawa, E. Goto, Y. Shirai. Serum and urinary boron levels in rats after single administration of sodium tetraborate. Arch Toxicol. 72, 468–74 (1998).
A. Arancibia, F. Corvalan, F. Mella, L. Concha. Absorption and disposition kinetics of lithium carbonate following administration of conventional and controlled release formulations. Int J Clin Pharmacol Ther Toxicol. 24, 240–5 (1986).
J. M. Warren and H. Spencer. Metabolic balances of strontium in man. Clin Orthop Relat Res. 117, 307–20 (1976).
T. Dote, K. Kono, Y. Tanimura, H. Nagaie, Y. Yoshida Serum and urine fluoride level after fluoride administration in rats with experimental renal dysfunction. Trace Elem. Med. 10, 112–114 (1993).
S. Hayashi, K. Usuda, G. Mitsui, T. Shibutani, E. Dote, K. Adachi, M. Fujihara, Y. Shimbo, W. Sun, R. Kono, H. Tsuji, K. Kono. Urinary yttrium excretion and effects of yttrium chloride on renal function in rats. Biol Trace Elem Res. 114, 225–35 (2006).
A. N. Øksendal. Biodistribution and toxicity of MR imaging contrast media. J Magn Reson Imaging 3, 157–165 (1993).
P.M. Waring and R.J. Watling. Rare earth deposits in a deceased movie projectionist. A new case of rare earth pneumoconiosis? Med J Aust. 153, 726–30 (1990).
S. Hirano, N. Kodama, K. Shibata, K.T. Suzuki. Metabolism and toxicity of intravenously injected yttrium chloride in rats. Toxicol Appl Pharmacol. 121, 224–32 (1993).
L.R.Willis, P.W.McCallum, J.T.Higgins Jr. Exaggerated natriuresis in the conscious spontaneously hypertensive rat. J Lab Clin Med. 87, 265–72 (1976).
Z. Liu, Z. Lei, X. Wei, B. Xue. The effects of exposure to rare earth (NO3)3 on the immune function of mice off spring via milk. Zhonghua Yu Fang Yi Xue Za Zhi. 36, 394–7 (2002).
N. Sotogaku, K. Endo, R. Hirunuma, S. Enomoto, S. Ambe, F. Ambe. Binding properties of various metals to blood components and serum proteins: a multitracer study. J Trace Elem Med Biol. 13, 1–6 (1999).
E. Sabbioni, R. Pietra, P. Gaglione, G. Vocaturo, F. Colombo, M. Zanoni, F. Rodi. Long-term occupational risk of rare-earth pneumoconiosis. A case report as investigated by neutron activation analysis. Sci Total Environ. 26, 19–32 (1982).
G. Vocaturo, F. Colombo, M. Zanoni, F. Rodi, E. Sabbioni, R. Pietra. Human exposure to heavy metals. Rare earth pneumoconiosis in occupational workers. Chest. 83, 780–3 (1983).
S. Porru, D. Placidi, C. Quarta, E. Sabbioni, R. Pietra, S. Fortaner. The potencial role of rare earths in the pathogenesis of interstitial lung disease: a case report of movie projectionist as investigated by neutron activation analysis. J Trace Elem Med Biol. 14, 232–6 (2001).
X.A. Chen, Y.E.Cheng, Z. Rong. Recent results from a study of thorium lung burdens and health effects among miners in China. J Radiol Prot. 25, 451–60 (2005).
C.J.McClain, M. McClain, S. Barve, M.G.Boosalis. Trace metals and the elderly. Clin Geriatr Med.18, 801–18 (2002)
M.E.Gershwin and L. Hurley. Trace metals and immune function in the elderly. Compr Ther.13, 18–23 (1987).
K. Usuda, K. Kono, K. Iguchi, K. Nishiura, K. Miyata, M. Shimahara, T. Konda, N. Hashiguchi, J. Senda. Hemodialysis effect on serum boron level in the patients with long term hemodialysis. Sci Total Environ. 191, 283–90 (1996).
K. Usuda, K. Kono, T. Watanabe, T. Dote, H. Shimizu, M. Tominaga, C. Koizumi, H. Nishiura, E. Goto, H. Nakaya, M. Arisue, A. Fukutomi. Hemodialyzability of ionizable fluoride in hemodialysis session. Sci Total Environ. 297, 183–91 (2002).
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Tanida, E., Usuda, K., Kono, K. et al. Urinary Scandium as Predictor of Exposure: Effects of Scandium Chloride Hexahydrate on Renal Function in Rats. Biol Trace Elem Res 130, 273–282 (2009). https://doi.org/10.1007/s12011-009-8337-6
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DOI: https://doi.org/10.1007/s12011-009-8337-6