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Contribution to the Data on Copper Concentration in Blood and Urine in Patients with Wilson’s Disease and in Normal Subjects

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Abstract

Determination of copper in human tissues and body fluids may be crucial in the diagnosis of Wilson’s disease. In this study we evaluated urinary copper excretion and urine and blood concentration in 14 patients in whom Wilson’s disease was confirmed (group A) and in 21 subjects in whom the disease was only suspected (group B). The following values (mean ± SD) were found: 24-h urine (μg Cu/24 h), 152 ± 135 (A) and 31.8 ± 10.9 (B); urine (μg Cu/ml), 0.091 ± 0.087 (A) and 0.028 ± 0.011 (B); and blood (μg Cu/ml), 0.62 ± 0.25 (A) and 0.72 ± 0.09 (B). By comparison, urine copper concentration in the group of apparently healthy subjects was 0.035 ± 0.010 (n = 50), and blood copper concentration in autopsy cases of nonpoisoned people was 0.85 ± 0.19 (n = 73).

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References

  1. Loudianos G, Gitlin JD (2000) Wilson’s disease. Semin Liver Dis 20:252–364

    Article  Google Scholar 

  2. Langner C, Denk H (2004) Wilson disease. Virchows Arch 445:111–118

    PubMed  CAS  Google Scholar 

  3. Tankanov RM (1991) Pathophysiology and treatment of Wilson’s disease. Clin Pharm 10:839–849

    Google Scholar 

  4. Gitlin JD (2003) Wilson disease. Gastroenterology 125:1868–1877

    Article  PubMed  Google Scholar 

  5. Asseth J, Morseth T (1986) Copper. In: Friberg L, Nordberg GF, Vouk VB (eds) Handbook on the toxicology of metals, vol. 2. Elsevier, Amsterdam, pp 233–254

    Google Scholar 

  6. Yuce A, Kocak N, Demir H, Gurakan F, Ozen H, Saltik IN, Ozcay F (2003) Evaluation of diagnostic parameters of Wilson’s disease in childhood. Indian J Gastroenterol 22:4–6

    PubMed  Google Scholar 

  7. Vanderwerf SM, Cooper MJ, Stetsenko IV, Lutsenko S (2001) Copper specifically regulates intracellular phosphorylation of the Wilson’s disease protein, a human copper-transporting ATPase. J Biol Chem 276:36289–36294

    Article  PubMed  CAS  Google Scholar 

  8. Roberts EA, Schilsky MLA (2003) A practice guideline on Wilson disease. Hepatology 37:1475–1492

    Article  PubMed  Google Scholar 

  9. Stremmel W (1996) Aktuelle Diagnostik: hereditare Stoffwechselerkrangungen der Leber (primare Hëmochromatose, Morbus Wilson). Schweiz Rundsch Med Prax 85:1513–1517

    PubMed  CAS  Google Scholar 

  10. Cauza E, Maier-Dobersberger T, Polli C, Kaserer K, Kramer L, Ferenci P (1997) Screening for Wilson’s disease in patients with liver diseases by serum ceruloplasmin. J Hepatol 27:358–362

    Article  PubMed  CAS  Google Scholar 

  11. Smolarek C, Stremmel W (1999) Therapy der Morbus Wilson. Z Gastroenterol 37:293–300

    PubMed  CAS  Google Scholar 

  12. Rath HG, Enger IM, Ruschoff J, Schmolmerich J, Holstege A (1997) Akute hämolytische Krise als Erstmanifestation eines Morbus Wilson. Z Gastroenterol 35:199–203

    PubMed  CAS  Google Scholar 

  13. Keller R, Torta R, Lagget M, Crasto S, Bergamasco B (1999) Psychiatric symptoms as late onset of Wilson’s disease: neurological findings, clinical features and treatment. Ital J Neurol Sci 20:49–54

    Article  PubMed  CAS  Google Scholar 

  14. Iyengar GV, Kollmer WE, Bowen HJM (1978) The elemental composition of human tissues and body fluids. A compilation of values for adults. Verlag Chemie, Weinheim

    Google Scholar 

  15. Plenert W, Heine W (1978) Normalwerte. VEB Verlag Volk und Gesundheit, Berlin

    Google Scholar 

  16. Haswell SJ (ed) (1991) Atomic absorption spectrometry. Theory, design and applications. Elsevier, Amsterdam, pp 368–370

  17. Hamilton EI, Sabbioni E, Van der Venne MT (1994) Element reference values in tissues from inhabitants of the European Community. VI. Review of elements in blood, plasma and urine and a critical evaluation of reference values for the United Kingdom population. Sci Total Environ 158:165–190

    Article  PubMed  CAS  Google Scholar 

  18. Lech T, Hydzik P (2007) Significance of copper determination in late onset of Wilson’s disease. Clin Toxicol (in press)

  19. Tietz NW (ed) (1995) Clinical guide to laboratory tests. W. B. Sanders Company, Philadelphia, pp 168–169

  20. Piekoszewski W, Pach J, Sadlik K, Winnik L (2000) Changes in serum copper level during detoxification of acutely poisoned drug addicts. Biol Trace Elem Res 78:1–6

    Article  PubMed  CAS  Google Scholar 

  21. Barany E, Bergdahl IA, Bratteby LE, Lundh T, Samuelson G, Schutz A, Skerfing S, Oskarsson A (2002) Trace element levels in whole blood and serum from Swedish adolescents. Sci Total Environ 286:129–141

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank Dr. Joanna Furgał, Dr. Monika Rudzińska, and other neurologists from Department of Neurology, Collegium Medicum, Jagiellonian University, Kraków, Poland, for providing blood and urine samples for copper determinations.

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  1. Institute of Forensic Research, ul. Westerplatte 9, 31-033, Kraków, Poland

    T. Lech & J. K. Sadlik

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  1. T. Lech
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  2. J. K. Sadlik
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Correspondence to T. Lech.

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Lech, T., Sadlik, J.K. Contribution to the Data on Copper Concentration in Blood and Urine in Patients with Wilson’s Disease and in Normal Subjects. Biol Trace Elem Res 118, 16–20 (2007). https://doi.org/10.1007/s12011-007-0015-y

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