Skip to main content

Advertisement

SpringerLink
Log in

Gold Nanomaterials: Preparation, Chemical Modification, Biomedical Applications and Potential Risk Assessment

  • Published:
Applied Biochemistry and Biotechnology Aims and scope Submit manuscript

Abstract

Gold nanomaterials (Au NMs) have attracted increasing attention in biomedicine due to their facile preparation, multifunctional modifications, unique optical and electrical properties, and good biocompatibility. The physicochemical properties of Au NMs at nanoscale, like size, shape, surface chemistry, and near field effects, are rendering Au NMs potent candidates in biomedicine. Thus, risk assessment of negative effects of Au NMs on biological systems is becoming urgent and necessary for future applications. In this review, we summarize up-to-date progresses on the preparation and modification of Au NMs and their biomedical applications, including biosensor, bioimaging and phototherapy, gene/drug delivery. Finally, we discuss the potential risk of Au NMs to biological systems, which is instructive for rationally designing and preparing nanomaterials for safe applications in nanomedicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Nie, S., & Emory, S. R. (1997). Science, 275, 1102–1106.

    Article  CAS  Google Scholar 

  2. Schmid, G. (1992). Chemical Reviews, 92, 1709–1727.

    Article  CAS  Google Scholar 

  3. Liu, X., Dai, Q., Austin, L., Coutts, J., Knowles, G., Zou, J., et al. (2008). Journal of the American Chemical Society, 130, 2780–2782.

    Article  CAS  Google Scholar 

  4. Durr, N. J., Larson, T., Smith, D. K., Korgel, B. A., Sokolov, K., & Ben-Yakar, A. (2007). Nano letters, 7, 941–945.

    Article  CAS  Google Scholar 

  5. Imura, K., Nagahara, T., & Okamoto, H. (2005). The Journal of Physical Chemistry B, 109, 13214–13220.

    Article  CAS  Google Scholar 

  6. Salem, A. K., Searson, P. C., & Leong, K. W. (2003). Nature Materials, 2, 668–671.

    Article  CAS  Google Scholar 

  7. Chen, C.-C., Lin, Y.-P., Wang, C.-W., Tzeng, H.-C., Wu, C.-H., Chen, Y.-C., et al. (2006). Journal of the American Chemical Society, 128, 3709–3715.

    Article  CAS  Google Scholar 

  8. Mie, G. (1908). Annalen der Physik, 330, 377–445.

    Article  Google Scholar 

  9. Wang, L., Liu, Y., Li, W., Jiang, X., Ji, Y., Wu, X., et al. (2011). Nano letters, 11, 772–780.

    Article  CAS  Google Scholar 

  10. Wang, L., Li, Y. F., Zhou, L., Liu, Y., Meng, L., Zhang, K., et al. (2010). Analytical and Bioanalytical Chemistry, 396, 1105–1114.

    Article  CAS  Google Scholar 

  11. Grabar, K. C., Freeman, R. G., Hommer, M. B., & Natan, M. J. (1995). Analytical chemistry, 67, 735–743.

    Article  CAS  Google Scholar 

  12. Busbee, B. D., Obare, S. O., & Murphy, C. J. (2003). Advanced Materials, 15, 414–416.

    Article  CAS  Google Scholar 

  13. Qiu, Y., Liu, Y., Wang, L., Xu, L., Bai, R., Ji, Y., et al. (2010). Biomaterials, 31, 7606–7619.

    Article  CAS  Google Scholar 

  14. Khlebtsov, N., & Dykman, L. (2011). Chemical Society Reviews, 40, 1647–1671.

    Article  CAS  Google Scholar 

  15. Zhao, Y., Xing, G., & Chai, Z. (2008). Nature Nanotechnology, 3, 191–192.

    Article  CAS  Google Scholar 

  16. Wang, J., Zhou, G., Chen, C., Yu, H., Wang, T., Ma, Y., et al. (2007). Toxicology letters, 168, 176–185.

    Article  CAS  Google Scholar 

  17. Chen, Z., Meng, H., Xing, G., Chen, C., Zhao, Y., Jia, G., et al. (2006). Toxicology letters, 163, 109–120.

    Article  CAS  Google Scholar 

  18. Qu, Y., Li, W., Zhou, Y., Liu, X., Zhang, L., Wang, L., et al. (2011). Nano letters, 11, 3174–3183.

    Article  CAS  Google Scholar 

  19. Liu, Y., Li, W., Lao, F., Liu, Y., Wang, L., Bai, R., et al. (2011). Biomaterials, 32, 8291–8303.

    Article  CAS  Google Scholar 

  20. Zhou, M., Wang, B., Rozynek, Z., Xie, Z., Fossum, J. O., Yu, X., et al. (2009). Nanotechnology, 20, 505606–505615.

    Article  CAS  Google Scholar 

  21. Murawala, P., Phadnis, S., Bhonde, R., & Prasad, B. (2009). Colloids and Surfaces B: Biointerfaces, 73, 224–228.

    Article  CAS  Google Scholar 

  22. Lasagna-Reeves, C., Gonzalez-Romero, D., Barria, M. A., Olmedo, I., Clos, A., & Sadagopa Ramanujam, V. M. (2010). Biochemical and Biophysical Research Communications, 393, 649–655.

    Article  CAS  Google Scholar 

  23. Li, J. J., Zou, L., Hartono, D., Ong, C. N., Bay, B. H., & Lanry Yung, L. Y. (2008). Advanced Materials, 20, 138–142.

    Article  CAS  Google Scholar 

  24. Dykman, L., & Khlebtsov, N. (2011). Chem Soc Rev. doi:10.1039/c1cs15166e.

  25. El-Sayed, I. H., Huang, X., & El-Sayed, M. A. (2005). Nano letters, 5, 829–834.

    Article  CAS  Google Scholar 

  26. Martin, C. R. (1994). Science, 266, 1961–1966.

    Article  CAS  Google Scholar 

  27. Foss, C. A., Jr., Hornyak, G. L., Stockert, J. A., & Martin, C. R. (1992). The Journal of Physical Chemistry, 96, 7497–7499.

    Article  CAS  Google Scholar 

  28. Martin, C. R. (1996). Chemistry of Materials, 8, 1739–1746.

    Article  CAS  Google Scholar 

  29. Jana, N. R., Gearheart, L., & Murphy, C. J. (2001). The Journal of Physical Chemistry B, 105, 4065–4067.

    Article  CAS  Google Scholar 

  30. Yu, Y. Y., Chang, S. S., Lee, C. L., & Wang, C. R. C. (1997). The Journal of Physical Chemistry B, 101, 6661–6664.

    Article  CAS  Google Scholar 

  31. Martin, B. R., Dermody, D. J., Reiss, B. D., Fang, M., Lyon, L. A., Natan, M. J., et al. (1999). Advanced Materials, 11, 1021–1025.

    Article  CAS  Google Scholar 

  32. van der Zande, B. M. I., Böhmer, M. R., Fokkink, L. G. J., & Schönenberger, C. (2000). Langmuir, 16, 451–458.

    Article  CAS  Google Scholar 

  33. Penner, R. M., & Martin, C. R. (1987). Analytical Chemistry, 59, 2625–2630.

    Article  CAS  Google Scholar 

  34. Kim, Y.-G., Oh, S.-K., & Crooks, R. M. (2003). Chemistry of Materials, 16, 167–172.

    Article  CAS  Google Scholar 

  35. Frens, G. (1973). Nature, 241, 20–22.

    CAS  Google Scholar 

  36. Kuo, C. H., Chiang, T. F., Chen, L. J., & Huang, M. H. (2004). Langmuir, 20, 7820–7824.

    Article  CAS  Google Scholar 

  37. Kwon, K., Lee, K. Y., Lee, Y. W., Kim, M., Heo, J., Ahn, S. J., et al. (2007). The Journal of Physical Chemistry C, 111, 1161–1165.

    Article  CAS  Google Scholar 

  38. Kan, C., Wang, C., Zhu, J., & Li, H. (2010). Journal of Solid State Chemistry, 183, 858–865.

    Article  CAS  Google Scholar 

  39. Nguyen, D. T., Kim, D.-J., & Kim, K.-S. (2011). Micron, 42, 207–227.

    Article  CAS  Google Scholar 

  40. Nikoobakht, B., & El-Sayed, M. A. (2003). Chemistry of Materials, 15, 1957–1962.

    Article  CAS  Google Scholar 

  41. Alkilany, A. M., Nagaria, P. K., Hexel, C. R., Shaw, T. J., Murphy, C. J., & Wyatt, M. D. (2009). Small, 5, 701–708.

    Article  CAS  Google Scholar 

  42. Daniel, M. C., & Astruc, D. (2004). Chemical Reviews, 104, 293–346.

    Article  CAS  Google Scholar 

  43. Rosi, N. L., & Mirkin, C. A. (2005). Chemical Reviews, 105, 1547–1562.

    Article  CAS  Google Scholar 

  44. Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., et al. (2006). Journal of Controlled Release, 114, 343–347.

    Article  CAS  Google Scholar 

  45. Ghosh, P. S., Kim, C.-K., Han, G., Forbes, N. S., & Rotello, V. M. (2008). ACS Nano, 2, 2213–2218.

    Article  CAS  Google Scholar 

  46. Chithrani, B. D., Ghazani, A. A., & Chan, W. C. W. (2006). Nano letters, 6, 662–668.

    Article  CAS  Google Scholar 

  47. Yang, P.-H., Sun, X., Chiu, J.-F., Sun, H., & He, Q.-Y. (2005). Bioconjugate Chemistry, 16, 494–496.

    Article  CAS  Google Scholar 

  48. Thomas, M., & Klibanov, A. M. (2003). Proceedings of the National Academy of Sciences, 100, 9138–9143.

    Article  CAS  Google Scholar 

  49. Bowman, M. C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., & Melander, C. (2008). Journal of the American Chemical Society, 130, 6896–6897.

    Article  CAS  Google Scholar 

  50. Kim, C. K., Ghosh, P., Pagliuca, C., Zhu, Z. J., Menichetti, S., & Rotello, V. M. (2009). Journal of the American Chemical Society, 131, 1360–1361.

    Article  CAS  Google Scholar 

  51. Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006). Science, 312, 1027–1030.

    Article  CAS  Google Scholar 

  52. Seferos, D. S., Giljohann, D. A., Rosi, N. L., & Mirkin, C. A. (2007). Chem Bio Chem, 8, 1230–1232.

    CAS  Google Scholar 

  53. Zheng, D., Seferos, D. S., Giljohann, D. A., Patel, P. C., & Mirkin, C. A. (2009). Nano letters, 9, 3258–3261.

    Article  CAS  Google Scholar 

  54. Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A. (2009). Journal of the American Chemical Society, 131, 2072–2073.

    Article  CAS  Google Scholar 

  55. Medley, C. D., Smith, J. E., Tang, Z., Wu, Y., Bamrungsap, S., & Tan, W. (2008). Analytical chemistry, 80, 1067–1072.

    Article  CAS  Google Scholar 

  56. Tkachenko, A. G., Xie, H., Coleman, D., Glomm, W., Ryan, J., Anderson, M. F., et al. (2003). Journal of the American Chemical Society, 125, 4700–4701.

    Article  CAS  Google Scholar 

  57. Patel, P. C., Giljohann, D. A., Seferos, D. S., & Mirkin, C. A. (2008). Proceedings of the National Academy of Sciences, 105, 17222–17226.

    Article  CAS  Google Scholar 

  58. Nitin, N., Javier, D. J., & Richards-Kortum, R. (2007). Bioconjugate Chemistry, 18, 2090–2096.

    Article  CAS  Google Scholar 

  59. Loo, C., Lowery, A., Halas, N., West, J., & Drezek, R. (2005). Nano letters, 5, 709–711.

    Article  CAS  Google Scholar 

  60. Cormode, D. P., Skajaa, T., Van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., et al. (2008). Nano letters, 8, 3715–3723.

    Article  CAS  Google Scholar 

  61. Haes, A. J., & Van Duyne, R. P. (2002). Journal of the American Chemical Society, 124, 10596–10604.

    Article  CAS  Google Scholar 

  62. Lee, K. S., & El-Sayed, M. A. (2006). The Journal of Physical Chemistry B, 110, 19220–19225.

    Article  CAS  Google Scholar 

  63. Underwood, S., & Mulvaney, P. (1994). Langmuir, 10, 3427–3430.

    Article  CAS  Google Scholar 

  64. Perez-Juste, J., Pastoriza-Santos, I., Liz-Marzan, L. M., & Mulvaney, P. (2005). Coordination Chemistry Reviews, 249, 1870–1901.

    Article  CAS  Google Scholar 

  65. Jain, P. K., & El-Sayed, M. A. (2007). The Journal of Physical Chemistry C, 111, 17451–17454.

    Article  CAS  Google Scholar 

  66. Yu, C., & Irudayaraj, J. (2007). Analytical chemistry, 79, 572–579.

    Article  CAS  Google Scholar 

  67. He, W., Liu, Y., Yuan, J., Yin, J. J., Wu, X., Hu, X., et al. (2010). Biomaterials, 32, 1139–1147.

    Article  CAS  Google Scholar 

  68. Kelly, K. L., Coronado, E., Zhao, L. L., & Schatz, G. C. (2003). The Journal of Physical Chemistry B, 107, 668–677.

    Article  CAS  Google Scholar 

  69. Link, S., & El-Sayed, M. A. (2000). International Reviews in Physical Chemistry, 19, 409–454.

    Article  CAS  Google Scholar 

  70. Oldenburg, S., Averitt, R., Westcott, S., & Halas, N. (1998). Chemical Physics Letters, 288, 243–247.

    Article  CAS  Google Scholar 

  71. El-Sayed, I. H., Huang, X., & El-Sayed, M. A. (2006). Cancer Letters, 239, 129–135.

    Article  CAS  Google Scholar 

  72. Wang, H., Huff, T. B., Zweifel, D. A., He, W., Low, P. S., Wei, A., et al. (2005). PNAS, 102, 15752–15756.

    Article  CAS  Google Scholar 

  73. Huff, T. B., Tong, L., Zhao, Y., Hansen, M. N., Cheng, J. X., & Wei, A. (2007). Nanomedicine, 2, 125–132.

    Article  CAS  Google Scholar 

  74. Tong, L., Zhao, Y., Huff, T. B., Hansen, M. N., Wei, A., & Cheng, J. X. (2007). Advanced Materials, 19, 3136–3141.

    Article  CAS  Google Scholar 

  75. Panyam, J., & Labhasetwar, V. (2003). Advanced Drug Delivery Reviews, 55, 329–347.

    Article  CAS  Google Scholar 

  76. Liu, Y., Chen, X., & Xin, J. (2006). Journal of materials science, 41, 5399–5401.

    Article  CAS  Google Scholar 

  77. Liu, Y., Miyoshi, H., & Nakamura, M. (2006). Journal of controlled release, 114, 89–99.

    Article  CAS  Google Scholar 

  78. Okuda, T., Kawakami, S., Akimoto, N., Niidome, T., Yamashita, F., & Hashida, M. (2006). Journal of controlled release, 116, 330–336.

    Article  CAS  Google Scholar 

  79. Moghimi, S., & Szebeni, J. (2003). Progress in lipid research, 42, 463–478.

    Article  CAS  Google Scholar 

  80. Turkevich, J., Stevenson, P. C., & Hillier, J. (1951). Discussions of the Faraday Society, 11, 55–75.

    Article  Google Scholar 

  81. Brust, M., Walker, M., Bethell, D., Schiffrin, D., & Whyman, R. (1994). Journal of the Chemical Society, Chemical Communications, 7, 801–802.

    Article  Google Scholar 

  82. Templeton, A. C., Wuelfing, W. P., & Murray, R. W. (2000). Accounts of Chemical Research, 33, 27–36.

    Article  CAS  Google Scholar 

  83. Paciotti, G. F., Myer, L., Weinreich, D., Goia, D., Pavel, N., McLaughlin, R. E., et al. (2004). Drug delivery, 11, 169–183.

    Article  CAS  Google Scholar 

  84. Paciotti, G. F., Kingston, D. G. I., & Tamarkin, L. (2006). Drug development research, 67, 47–54.

    Article  CAS  Google Scholar 

  85. Hostetler, M. J., Wingate, J. E., Zhong, C. J., Harris, J. E., Vachet, R. W., Clark, M. R., et al. (1998). Langmuir, 14, 17–30.

    Article  CAS  Google Scholar 

  86. Ghosh, P., Han, G., De, M., Kim, C. K., & Rotello, V. M. (2008). Advanced Drug Delivery Reviews, 60, 1307–1315.

    Article  CAS  Google Scholar 

  87. Oishi, M., Nakaogami, J., Ishii, T., & Nagasaki, Y. (2006). Chemistry Letters, 35, 1046–1047.

    Article  CAS  Google Scholar 

  88. Bhumkar, D. R., Joshi, H. M., Sastry, M., & Pokharkar, V. B. (2007). Pharmaceutical Research, 24, 1415–1426.

    Article  CAS  Google Scholar 

  89. Li, W., Huang, Z., MacKay, J. A., Grube, S., & Szoka, F. C. (2005). The Journal of Gene Medicine, 7, 67–79.

    Article  CAS  Google Scholar 

  90. Polizzi, M. A., Stasko, N. A., & Schoenfisch, M. H. (2007). Langmuir, 23, 4938–4943.

    Article  CAS  Google Scholar 

  91. Han, G., You, C.-C., Kim, B.-J., Turingan, R. S., Forbes, N. S., Martin, C. T., et al. (2006). Angewandte Chemie International Edition, 45, 3165–3169.

    Article  CAS  Google Scholar 

  92. Han, G., You, C. C., Kim, B., Turingan, R. S., Forbes, N. S., Martin, C. T., et al. (2006). Angewandte Chemie, 118, 3237–3241.

    Article  Google Scholar 

  93. Grabinski, C., Schaeublin, N., Wijaya, A., D’Couto, H., Baxamusa, S. H., Hamad-Schifferli, K., et al. (2011). ACS Nano, 5, 2870–2879.

    Article  CAS  Google Scholar 

  94. Kirui, D. K., Krishnan, S., Strickland, A. D., & Batt, C. A. (2011). Macromolecular Bioscience, 11, 779–788.

    Article  CAS  Google Scholar 

  95. De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008). Biomaterials, 29, 1912–1919.

    Article  CAS  Google Scholar 

  96. Pan, Y., Neuss, S., Leifert, A., Fischler, M., Wen, F., Simon, U., et al. (2007). Small, 3, 1941–1949.

    Article  CAS  Google Scholar 

  97. Lin, J., Zhang, H., Chen, Z., & Zheng, Y. (2010). ACS Nano, 4, 5421–5429.

    Article  CAS  Google Scholar 

  98. Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005). Small, 1, 325–327.

    Article  CAS  Google Scholar 

  99. Pernodet, N., Fang, X., Sun, Y., Bakhtina, A., Ramakrishnan, A., Sokolov, J., et al. (2006). Small, 2, 766–773.

    Article  CAS  Google Scholar 

  100. Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005). Langmuir, 21, 10644–10654.

    Article  CAS  Google Scholar 

  101. Rayavarapu, R. G., Petersen, W., Hartsuiker, L., Chin, P., Janssen, H., van Leeuwen, F. W. B., et al. (2010). Nanotechnology, 21, 145101–145110.

    Article  CAS  Google Scholar 

  102. Chen, Y. S., Hung, Y. C., Liau, I., & Huang, G. S. (2009). Nanoscale research letters, 4, 858–864.

    Article  CAS  Google Scholar 

  103. Cho, W. S., Cho, M., Jeong, J., Choi, M., Cho, H. Y., Han, B. S., et al. (2009). Toxicology and Applied Pharmacology, 236, 16–24.

    Article  CAS  Google Scholar 

  104. Cho, W. S., Kim, S., Han, B. S., Son, W. C., & Jeong, J. (2009). Toxicology letters, 191, 96–102.

    Article  CAS  Google Scholar 

  105. Balasubramanian, S. K., Jittiwat, J., Manikandan, J., Ong, C.-N., Yu, L. E., & Ong, W.-Y. (2010). Biomaterials, 31, 2034–2042.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the MOST 973 Program (2011CB933401 and 2012CB934003), the NSFC (31070854), and CAS Knowledge Innovation Projects.

Author information

Authors and Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China

    Xiu-Mei Jiang, Li-Ming Wang, Jing Wang & Chun-Ying Chen

  2. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China

    Li-Ming Wang

Authors
  1. Xiu-Mei Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-Ming Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chun-Ying Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chun-Ying Chen.

Additional information

Authors Xiu-Mei Jiang and Li-Ming Wang contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jiang, XM., Wang, LM., Wang, J. et al. Gold Nanomaterials: Preparation, Chemical Modification, Biomedical Applications and Potential Risk Assessment. Appl Biochem Biotechnol 166, 1533–1551 (2012). https://doi.org/10.1007/s12010-012-9548-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12010-012-9548-4

Keywords

Search

Navigation