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Review on the Angiotensin-I-Converting Enzyme (ACE) Inhibitor Peptides from Marine Proteins

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Abstract

Hypertension is now a major problem threatening people health in the world. Angiotensin-I-converting enzyme (ACE) plays an important physiological role in regulation of blood pressure via conversion of angiotensin I to angiotensin II. Inhibition of ACE may have an antihypertensive effect as a consequence of a decrease in blood pressure. A number of terrestrial-derived peptides have been reviewed about their in vitro and in vivo ACE-inhibitory activities. Marine organisms are potentially an untapped source of drugs and value-added food production. The aim of this review is to discuss the marine-derived ACE-inhibitory peptides from sources, production, structure aspects, and their future prospects as functional food or novel therapeutic drug candidates.

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References

  1. Johnston JI, Franz VL (1992) Journal of Hypertension 10(7):13–26

    Article  Google Scholar 

  2. Skeggs LT, Kahn JR, Shumway NP (1956) The Journal of Experimental Medicine 103(3):295–299

    Article  CAS  Google Scholar 

  3. Erdos EG, Skidgel RA (1987) Laboratory Investigation 56(4):345–348

    CAS  Google Scholar 

  4. Ribeiro-Oliveira A Jr, Nogueira AI, Pereira RM, Boas WWV, Santos RAS, Silva ACS (2008) Vascular Health and Risk Management 4(4):787–803

    CAS  Google Scholar 

  5. Erdös EG (1975) Circulation Research 36(2):247–255

    Article  Google Scholar 

  6. Atkinson AB, Robertson JIS (1979) Lancet 2(8147):836–839

    Article  CAS  Google Scholar 

  7. Pryde PG, Sedman AB, Nugent CE, Barr M (1993) Journal of the American Society of Nephrology 3:1575–1582

    CAS  Google Scholar 

  8. Cooper WO, Hernandez-Diaz S, Arbogast PG, Dudley JA (2006) New England Journal of Medicine 354(23):2443–2453

    Article  CAS  Google Scholar 

  9. Wijesekara I, Kim SK (2010) Marine Drugs 8(4):1080–1093

    Article  CAS  Google Scholar 

  10. Meisel H (1998) International Dairy Journal 8(5):363–373

    Article  CAS  Google Scholar 

  11. Guang C, Phillips RD (2009) Journal of Agricultural and Food Chemistry 57(12):5113–5120

    Article  CAS  Google Scholar 

  12. Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T (1995) Journal of Dairy Science 78(4):1253–1257

    Article  CAS  Google Scholar 

  13. Pihlanto-Leppala A (2001) Trends in Food Science and Technology 11(9):347–356

    Article  Google Scholar 

  14. Wu JP, Ding XL (2002) Food Research International 35(4):367–375

    Article  CAS  Google Scholar 

  15. Yoshii H, Tachi N, Ohba T, Sakamura O, Takeyama H, Itani T (2001) Comparative Biochemical Physics 128(1):27–33

    Article  CAS  Google Scholar 

  16. Arihara K, Nakashima Y, Mukai T, Ishikawa S, Itoh M (2001) Meat Science 57(3):319–324

    Article  CAS  Google Scholar 

  17. Nakagomi K, Yamada R, Ebisu H, Sadakane Y, Akizawa T, Tanimura T (2000) FEBS Letters 467(2):235–238

    Article  CAS  Google Scholar 

  18. Yust MM, Pedroche J, Giron-Calle J, Alaiz M, Millan F, Vioque J (2003) Food Chemistry 81(3):363–369

    Article  CAS  Google Scholar 

  19. Larsen R, Eilertsen KE, Elvevoll EO (2011) Biotechnology Advances 29(5):508–518

    Article  CAS  Google Scholar 

  20. Wang SL, Chang TJ, Liang TW (2010) Biochemical Engineering Journal 21(3):321–333

    CAS  Google Scholar 

  21. Zaman MA, Oparil S, Calhoum DA (2002) Nature 1(8):621–636

    Article  CAS  Google Scholar 

  22. Hartmann R, Meisel H (2007) Current Opinion in Biotechnology 18(2):163–169

    Article  CAS  Google Scholar 

  23. He HL, Chen XL, Sun CY, Zhang YZ, Gao PJ (2006) Bioresource Technology 97(3):385–390

    Article  CAS  Google Scholar 

  24. Cushman DW, Cheung HS (1971) Biochemistry and Pharmacology 20(7):1637–1648

    Article  CAS  Google Scholar 

  25. Matsui T, Matsufuji H, Osajima Y (1992) Bioscience Biotechnology and Biochemistry 56(3):517–518

    Article  CAS  Google Scholar 

  26. Li GH, Liu H, Shi YH, Le GW (2005) Journal of Pharmaceutical and Biomedical Analysis 37(2):219–224

    Article  CAS  Google Scholar 

  27. Wu JP, Aluko RE, Muir AD (2002) Journal of Chromatography A 950(1):125–130

    Article  CAS  Google Scholar 

  28. Zhang RZ, Xu XH, Chen TB, Li L, Rao PF (2000) Analytical Biochemistry 280(2):286–290

    Article  CAS  Google Scholar 

  29. He HL, Chen XL, Wu H, Sun CY, Zhang YZ, Zhou BC (2007) Bioresource Technology 98(18):3499–3505

    Article  CAS  Google Scholar 

  30. Holmquist B, Bünning P, Riordan JF (1979) Analytical Biochemistry 95(2):540–548

    Article  CAS  Google Scholar 

  31. Murray BA, Walsh DJ, FitzGeralg RJ (2004) Journal of Biochemical and Biophysical Methods 59(2):127–137

    Article  CAS  Google Scholar 

  32. Otte J, Shalaby SMA, Zakora M, Nielsen MS (2007) International Dairy Journal 17(12):1460–1472

    Article  CAS  Google Scholar 

  33. Shalaby SM, Zakora M, Otte J (2006) The Journal of Dairy Research 73(2):178–186

    Article  CAS  Google Scholar 

  34. Lahogue V, Réhel K, Taupin L, Haras D, Allaume P (2010) Food Chemistry 118(3):870–875

    Article  CAS  Google Scholar 

  35. Sentandreu MA, Toldra F (2006) Food Chemistry 97(3):546–554

    Article  CAS  Google Scholar 

  36. Pinto YM, Paul M, Ganten D (1998) Cardiovascular Research 39(1):77–88

    Article  CAS  Google Scholar 

  37. Diness JG, Skibsbye L, Jespersen T, Bartels ED, Sørensen US, Hansen RS, Grunnet M (2011) Hypertension 57(6):1129–1135

    Article  CAS  Google Scholar 

  38. Liu CF, Tung YT, Wu CL, Lee BH, Hsu WH, Pan TM (2011) Journal of Agricultural and Food Chemistry 59(9):4537–4543

    Article  CAS  Google Scholar 

  39. Okamoto AK (1963) Japan Circulatory Journal 27(3):282–293

    Article  CAS  Google Scholar 

  40. Jung WK, Mendis E, Je JY, Park PJ, Son BW, Kim HC, Choi YK, Kim SK (2006) Food Chemistry 94(1):26–32

    Article  CAS  Google Scholar 

  41. Fuglsanga A, Nilssonb D, Nyborgc NCB (2003) Journal of Enzyme Inhibition and Medicinal Chemistry 18(5):407–412

    Article  Google Scholar 

  42. Fujita H, Yokoyama K, Yoshikawa M (2000) Journal of Food Science 65(4):564–569

    Article  CAS  Google Scholar 

  43. Ferreira SH, Bartelt DC, Greene LJ (1970) Biochemistry 9(13):2583–2593

    Article  CAS  Google Scholar 

  44. Byun HG, Kim SK (2010) Process Biochemistry 36(12):1155–1162

    Article  Google Scholar 

  45. Qian ZJ, Je JY, Kim SK (2007) Journal of Agricultural and Food Chemistry 55(21):8398–8403

    Article  CAS  Google Scholar 

  46. Je JY, Park PJ, Jung WK, Kim SK (2005) Food Chemistry 90(4):809–814

    Article  CAS  Google Scholar 

  47. Wang J, Hu J, Cui J, Bai X, Du Y, Miyaguchi Y, Lin B (2008) Food Chemistry 111(2):302–308

    Article  CAS  Google Scholar 

  48. Sheih IC, Fang TJ, Wu TK (2009) Food Chemistry 115(1):279–284

    Article  CAS  Google Scholar 

  49. Wu H, He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC (2008) Process Biochemistry 43(4):457–461

    Article  CAS  Google Scholar 

  50. Bougatef A, Nedjar-Arroume N, Ravallec-Plé R, Leroy Y, Guillochon D, Barkia A, Nasri M (2008) Food Chemistry 111(2):350–356

    Article  CAS  Google Scholar 

  51. Je JY, Park PJ, Byun HG, Jung WK, Kim SK (2005) Bioresource Technology 96(14):1624–1629

    Article  CAS  Google Scholar 

  52. Nakajima K, Yoshie-Stark Y, Ogushi M (2009) Food Chemistry 114(3):844–851

    Article  CAS  Google Scholar 

  53. Qu WJ, Ma HL, Pan ZL, Luo L, Wang ZB, He RH (2010) Food Chemistry 123(1):14–20

    Article  CAS  Google Scholar 

  54. Wijesinghe WAJP, Ko SC, Jeon YJ (2011) Nutrition Research Practice 5(2):93–100

    Article  CAS  Google Scholar 

  55. Balti R, Nedjar-Arroume N, Bougatef A, Guillochon D, Nasri M (2010) Food Research International 43(4):1136–1143

    Article  CAS  Google Scholar 

  56. Lee SH, Qian ZJ, Kima SK (2010) Food Chemistry 118(1):96–102

    Article  CAS  Google Scholar 

  57. Wijesekara I, Qian ZJ, Ryu BM, Ngo DH, Kima SK (2011) Food Research International 44(3):703–707

    Article  CAS  Google Scholar 

  58. Zhao YH, Li BF, Liu ZY, Dong SY, Zhao X, Zeng MY (2007) Process Biochemistry 42(12):1586–1591

    Article  CAS  Google Scholar 

  59. Gu RZ, Li CY, Liu WY, Yi WX, Cai MY (2011) Food Research International 44(5):1536–1540

    Article  CAS  Google Scholar 

  60. Balti R, Nedjar-Arroume N, Adje EY, Guillochon D, Nasri M (2010) Journal of Agricultural and Food Chemistry 58(6):3840–3846

    Article  CAS  Google Scholar 

  61. Yokoyama H, Chiba H, Yoshikawa M (1992) Bioscience Biotechnology Biochemical 56(10):1541–1545

    Article  CAS  Google Scholar 

  62. Hasan F, Kitagawa M, Kumada Y, Hashimoto N, Shiiba M, Katoh S, Terashima M (2006) Process Biochemistry 41(3):505–511

    Article  CAS  Google Scholar 

  63. Cakir-Kiefer C, Le Roux Y, Balandras F, Trabalon M, Dary A, Laurent F, Gaillard JL, Miclo L (2011) Journal of Agricultural and Food Chemistry 59(9):4464–4472

    Article  CAS  Google Scholar 

  64. Zhao GY, Chen XL, Zhao HL, Xie BB, Zhou BC, Zhang YZ (2008) Journal of Biological Chemistry 283(52):36100–36107

    Article  CAS  Google Scholar 

  65. Margesin R, Schinner F (1994) Journal of Biotechnology 33(1):11–14

    Article  Google Scholar 

  66. Raghavan S, Kristinsson HG, Leeuwenburgh C (2008) Journal of Agricultural and Food Chemistry 56(21):10359–10367

    Article  CAS  Google Scholar 

  67. Cheung IWY, Li-Chan ECY (2010) Food Chemistry 122(4):1003–1012

    Article  CAS  Google Scholar 

  68. Wang YK, He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC (2008) Applied Microbiology and Biotechnology 79(5):785–791

    Article  CAS  Google Scholar 

  69. Li GH, Lea GW, Shi YH, Shrestha S (2004) Nutrition Research 24(7):469–486

    CAS  Google Scholar 

  70. Murray BA, FitzGerald RJ (2007) Current Pharmaceutical Design 13(8):773–791

    Article  CAS  Google Scholar 

  71. Byun HG, Kim SK (2002) Journal of Biochemistry and Molecular Biology 35(2):239–243

    Article  CAS  Google Scholar 

  72. Kumada Y, Hashimoto N, Hasan F, Terashima M, Nakanishi K, Jungbauer A, Katoh S (2007) Journal of Biotechnology 131(2):144–149

    Article  CAS  Google Scholar 

  73. Kobayashi Y, Yamauchi T, Katsuda T, Yamaji H, Katoh S (2008) Journal of Bioscience and Bioengineering 106(3):310–312

    Article  CAS  Google Scholar 

  74. Suetsuna K, Chen JR (2001) Marine Biotechnology 3(4):305–309

    Article  CAS  Google Scholar 

  75. Fujita H, Yoshikawa M (1999) Immunopharmacology 44(1–2):123–127

    Article  CAS  Google Scholar 

  76. Wu JP, Aluko RE, Nakai S (2006) QSAR and Combinatorial Science 25(10):873–880

    Article  CAS  Google Scholar 

  77. Meisel H, Walsh DJ, Murray BA, FitzGerald RJ (2005) Factors on the body’s regulation system. In: Mine Y, Shahidi F (eds) Nutraceutical proteins and peptides in health and disease. CRC Press, New York, pp 269–315

    Google Scholar 

  78. Dziuba J, Niklewicz M, Iwaniak A, Darewicz M, Minkiewicz P (2004) Acta Alimentos 33(3):227–235

    Article  CAS  Google Scholar 

  79. Vercruysse L, Smagghe G, Bent A, Amerongen A, Ongenaert M, Camp JV (2009) Peptides 30(3):575–582

    Article  CAS  Google Scholar 

  80. Gu YC, Majumder K, Wu JP (2011) Food Research International 44(8):2465–2474

    Article  CAS  Google Scholar 

  81. Ondetti MA (1977) Science 196(4288):441–444

    Article  CAS  Google Scholar 

  82. He HL, Wu H, Shi M, Zhang XY, Sun CY, Zhang YZ, Zhou BC (2008) Bioresource Technology 99(13):5956–5959

    Article  CAS  Google Scholar 

  83. Roberta PR, Burney JD, Black KW, Zaloga GP (1999) Digestion 60(4):332–337

    Article  Google Scholar 

  84. Ryan JT, Ross RP, Bolton D, Fitzgerald GF, Stanton C (2011) Nutrients 3(9):765–791

    Article  CAS  Google Scholar 

  85. Suetsuna K, Nakano T (2000) The Journal of Nutritional Biochemistry 11(9):450–454

    Article  CAS  Google Scholar 

  86. He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC (2006) Journal of Peptide Science 12(11):726–733

    Article  CAS  Google Scholar 

  87. Tsai JS, Chen JL, Pan BS (2008) Process Biochemistry 43(7):743–747

    Article  CAS  Google Scholar 

  88. Zhao YH, Li BF, Dong SY, Zhao X, Wang JF, Zeng MY (2009) Peptides 30(6):1028–1033

    Article  CAS  Google Scholar 

  89. Alemán A, Giménez B, Pérez-Santin E, Gómez-Guillén MC, Montero P (2011) Food Chemistry 125(2):334–341

    Article  Google Scholar 

  90. Ono S, Hosokawa M, Miyashita K, Takahashi K (2003) Journal of Food Science 5:1611–1614

    Article  Google Scholar 

  91. Lee JK, Jeon JK, Byun HG (2011) Food Chemistry 125(2):495–499

    Article  CAS  Google Scholar 

  92. Kawasaki T, Seki E, Osajima K, Yoshida M, Asada K, Matsui T, Osajima Y (2000) Journal of Human Hypertension 14(8):519–523

    Article  CAS  Google Scholar 

  93. Matsufuji H, Matsui T, Seki E, Osajima K, Nakashima M, Osajima Y (1994) Bioscience, Biotechnology Biochemical 58(12):2244–2245

    Article  CAS  Google Scholar 

  94. Fahmi A, Morimura S, Guo HC, Shigematsu T, Kida K, Uemura Y (2004) Process Biochemistry 39(10):1195–1200

    Article  CAS  Google Scholar 

  95. Ichimura T, Hu J, Aita DQ, Maruyama S (2003) Journal of Bioscience and Bioengineering 96(5):496–499

    CAS  Google Scholar 

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Acknowledgments

The work was supported by National Natural Science Foundation of China (31070061), Ocean Public Welfare Scientific Research Project, State Oceanic Administration People's Republic of China (201005032–6), China Postdoctoral Science Foundation (20100471513), and Science Foundation for Post Doctorate Research of Shandong Province (201003060).

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  1. School of Biological Science and Technology, Central South University, Changsha, 410013, China

    Hai-Lun He, Dan Liu & Chang-Bei Ma

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  1. Hai-Lun He
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Correspondence to Hai-Lun He.

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He, HL., Liu, D. & Ma, CB. Review on the Angiotensin-I-Converting Enzyme (ACE) Inhibitor Peptides from Marine Proteins. Appl Biochem Biotechnol 169, 738–749 (2013). https://doi.org/10.1007/s12010-012-0024-y

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