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Preparation and evaluation of a UV-curing hydrophilic semi-IPN coating for medical guidewires

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Abstract

Guidewires have crucial roles in intravascular, critical care, and urological applications. In recent years, the demand for guidewires with lower friction surfaces has arisen for medical applications. Among various surface lubrication strategies for guidewires, the most promising is the use of a hydrophilic coating. However, obtaining a hydrophilic coating on guidewires with strong adhesion remains difficult owing to the surface energy difference between the substrate and hydrophilic coating. Herein, we present a UV-curing semi-interpenetrating polymer network coating for medical thermoplastic polyurethane (TPU)-sheathed nitinol guidewires. A polyurethane acrylate (PUA) was synthesized and cured as a transition layer on the TPU substrate to provide strong adhesion. Then, polyvinyl pyrrolidone (PVP) and polyethylene glycol diacrylate (PEGDA) permeated into the PUA layer and cured to form the composite coating. The PUA–PEGDA–PVP coating exhibited excellent lubricity and satisfactory adhesion force. The surface coefficient of friction decreased to approximately 0.02 after modification with the coating, and the coating was stable during long-term soaking in water and repeated friction. In vitro toxicity tests revealed that the coating had good biocompatibility. Thus, our PUA–PEGDA–PVP coating has the potential for application as super-lubricity guidewires and other medical devices.

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References

  1. Kipling, M, Mohammed, A, Medding, RN, “Guidewires in Clinical Practice: Applications and Troubleshooting.” Expert Rev. Med. Devices, 6 (2) 187–195 (2009)

    Article  Google Scholar 

  2. Shabalovskaya, S, Anderegg, J, Humbeeck, JV, “Critical Overview of Nitinol Surfaces and Their Modifications for Medical Applications.” Acta Biomater., 4 (3) 447–467 (2008)

    Article  CAS  Google Scholar 

  3. Drelich, J, Chibowski, E, Meng, DD, Terpilowski, K, “Hydrophilic and Superhydrophilic Surfaces and Materials.” Soft Matter, 7 (21) 9804–9828 (2011)

    Article  CAS  Google Scholar 

  4. Liu, X, Xu, Y, Wu, Z, Chen, H, “Poly(N-vinylpyrrolidone)-modified Surfaces for Biomedical Applications.” Macromol. Biosci., 13 (2) 147–154 (2013)

    Article  Google Scholar 

  5. Tenorio-Neto, ET, Guilherme, MR, Lima-Tenorio, MK, Rubira, AF, Fessi, H, Kunita, MH, “Poly(ethylene glycol)-Based Hydrogels from Preparation Methods to Applications.” J. Colloid Sci. Biotechnol., 5 (1) 2–15 (2016)

    Article  CAS  Google Scholar 

  6. Lowe, S, O’Brien-Simpson, NM, Connal, LA, “Antibiofouling Polymer Interfaces: Poly(ethylene glycol) and Other Promising Candidates.” Polym. Chem., 6 (2) 198–212 (2015)

    Article  CAS  Google Scholar 

  7. Teodorescu, M, Bercea, M, “Poly(vinylpyrrolidone)—A Versatile Polymer for Biomedical and Beyond Medical Applications.” Polym. Plast. Technol. Eng., 54 (9) 923–943 (2015)

    CAS  Google Scholar 

  8. Chen, Y, Zhang, Y, Wu, Z, Peng, X, Su, T, Cao, J, He, B, Li, S, “Biodegradable Poly(ethylene glycol)-poly(epsilon-carprolactone) Polymeric Micelles with Different Tailored Topological Amphiphilies for Doxorubicin (DOX) Drug Delivery.” RSC Adv., 6 (63) 58160–58172 (2016)

    Article  CAS  Google Scholar 

  9. Galhenage, TP, Webster, DC, Moreira, AMS, Burgett, RJ, Stafslien, SJ, Vanderwal, L, Finlay, JA, Franco, SC, Clare, AS, “Poly(ethylene) Glycol-modified, Amphiphilic, Siloxane-polyurethane Coatings and Their Performance as Fouling-Release Surfaces.” J. Coat. Technol. Res., 14 307–322 (2017)

    Article  CAS  Google Scholar 

  10. Burdick, JA, Anseth, KS, “Photoencapsulation of Osteoblasts in Injectable RGD-modified PEG Hydrogels for Bone Tissue Engineering.” Biomaterials, 23 (22) 4315–4323 (2002)

    Article  CAS  Google Scholar 

  11. Le, TN, Lee, CK, “Surface Functionalization of Poly(N-vinylpyrrolidone) onto Poly(dimethylsiloxane) for Anti-biofilm Application.” Appl. Biochem. Biotechnol., 190 (6) 1559–1575 (2020)

    Google Scholar 

  12. Thalla, PK, Contreras-Garcia, A, Fadlallah, H, Barrette, J, De Crescenzo, G, Merhi, Y, Lerouge, S, “A Versatile Star PEG Grafting Method for the Generation of Nonfouling and Nonthrombogenic Surfaces.” BioMed Res. Int., 2013 (1) 962376 (2013)

    Google Scholar 

  13. Pawlowski, K, Dorniak, W, Klaudel, J, “Successful Primary PCI in a Patient with Single Coronary Artery.” Invasive Cardiol., 25 (6) E124–E127 (2013)

    Google Scholar 

  14. Pourmoghaddas, M, Fard, OH, “Retained Jailed Wire: A Case Report and Literature Review.” ARYA Atheroscler., 7 (3) 129–131 (2011)

    Google Scholar 

  15. Zhu, YW, Pei, L, Ambreen, J, He, CX, Ngai, T, “Facile Preparation of a Fluorine-free, Robust, Superhydrophobic Coating Through Dip Coating Combined with Non-solvent Induced Phase Separation (Dip-coating-NIPS) Method.” Macromol. Chem. Phys., 221 (7) 2000023 (2020)

    Article  CAS  Google Scholar 

  16. Kunst, SR, Cardoso, HRP, Menezes, TL, Malfatti, CD, “UV Curing Paint on Hybrid Films Modified with Plasticizer Diisodecyl Adipate Applied on Tinplate: The Effects of Curing Temperature and the Double Layer.” Ind. Eng. Chem. Res., 53 (49) 19216–19227 (2014)

    Article  CAS  Google Scholar 

  17. DeBruyn, K, VanStappen, M, DeDeurwaerder, H, Rouxhet, L, Celis, JP, “Study of Pretreatment Methods for Vacuum Metallization of Plastics.” Surf. Coat. Technol., 163 710–715 (2003)

    Article  Google Scholar 

  18. Fernandez, L, Sanchez, M, Carmona, FJ, Palacio, L, Calvo, JI, Hernandez, A, Pradanos, P, “Analysis of the Grafting Process of PVP on a Silicon Surface by AFM and Contact Angle.” Langmuir, 27 (18) 11636–11649 (2011)

    Article  CAS  Google Scholar 

  19. Quaglini, V, Dubini, P, “Friction of Polymers Sliding on Smooth Surfaces.” Adv. Tribol., 2011 178943–178951 (2011)

    Article  Google Scholar 

  20. Tang, W, Wan, TR, Gould, DA, How, T, John, NW, “A Stable and Real-time Nonlinear Elastic Approach to Simulating Guidewire and Catheter Insertions Based on Cosserat Rod.” IEEE Trans. Biomed. Eng., 59 (8) 2211–2218 (2012)

    Article  Google Scholar 

  21. Zhao, G, Wu, Y, Hu, J, Liu, G, Li, D, “Hemolysis Phenomenon of Pure Magnesium and Two Different Coating Pure Magnesium.” J. Clin. Rehabil. Tissue Eng. Res., 15 (34) 6339–6341 (2011)

    CAS  Google Scholar 

  22. Zvonkina, IJ, Hilt, M, “Tuning the Mechanical Performance and Adhesion of Polyurethane UV Cured Coatings by Composition of Acrylic Reactive Diluents.” Prog. Org. Coat., 89 288–296 (2015)

    Article  CAS  Google Scholar 

  23. Jiao, Z, Wang, X, Yang, Q, Wang, C, “Modification and Characterization of Urethane Acrylate Oligomers Used for UV-curable Coatings.” Polymer Bulletin, 74 (7) 2497–2511 (2016)

    Article  Google Scholar 

  24. Sahiner, M, Sagbas, S, Bitlisli, BO, “P(AAm/TA)-based IPN Hydrogel Films with Antimicrobial and Antioxidant Properties for Biomedical Applications.” J. Appl. Polym. Sci., 132 (16) 229–246 (2015)

    Article  Google Scholar 

  25. Liang, T, Li, HQ, Lai, XJ, Su, XJ, Zhang, L, Zeng, XR, “A Facile Approach to UV-Curable Super-hydrophilic Polyacrylate Coating Film Grafted on Glass Substrate.” J. Coat. Technol. Res., 13 (6) 1115–1121 (2016)

    Article  CAS  Google Scholar 

  26. Weiner, AA, Shuck, DM, Bush, JR, Shastri, VP, “In Vitro Degradation Characteristics of Photo Crosslinked Anhydride Systems for Bone Augmentation Applications.” Biomaterials, 28 (35) 5259–5270 (2007)

    Article  CAS  Google Scholar 

  27. Zhang, H, Wang, XL, Wang QQ, “Study on the Preparation and Properties of PEG Phase Change Materials Fixed by Semi-IPN.” Adv. Mater. Res., 299 654–658 (2011)

    Article  Google Scholar 

  28. Sharei, H, Alderliesten, T, van den Dobbelsteen, JJ, Dankelman, J, “Navigation of Guidewires and Catheters in the Body During Intervention Procedures: A Review of Computer-based Models.” J. Med. Imaging, 5 (1) 010902–010910 (2018)

    Article  Google Scholar 

  29. Xie, D, Liao, X, Zhou, A, “Interventional Therapy Study on Using Micro-catheter Joint with Guide Wire Private for Occlusion in Coronary Artery Chronic Total Occlusion.” Heart, 97 (suppl 3) A162–A162 (2011)

    Google Scholar 

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Author notes

  1. Wenfei Ding and Zheng Zhao have contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China

    Wenfei Ding, Zheng Zhao, Lingmei Jiang, Xigao Jian & Jinyan Wang

  2. Shanghai Kindly Medical Instruments co., LTD, Shanghai, 201800, China

    Wenfei Ding & Yuan Song

Authors
  1. Wenfei Ding
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  2. Zheng Zhao
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  3. Lingmei Jiang
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  4. Xigao Jian
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Correspondence to Jinyan Wang.

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Ding, W., Zhao, Z., Jiang, L. et al. Preparation and evaluation of a UV-curing hydrophilic semi-IPN coating for medical guidewires. J Coat Technol Res 18, 1027–1035 (2021). https://doi.org/10.1007/s11998-020-00455-9

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  • DOI: https://doi.org/10.1007/s11998-020-00455-9

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