Abstract
With the change of people’s dietary structures, obesity, diabetes, and other related chronic metabolic diseases characterized by energy metabolism disorders have become a public health problem worldwide. Stable isotope-resolved metabolomics (SIRM) as a novel technology to explore energy metabolism will certainly contribute to the development of functional foods to improve energy metabolism disorders. The purpose of this review is to elaborate on the technology processes of SIRM in the research of functional foods with improved energy metabolism disorders, and to promote the applications of this technology in functional food. The research strategies for functional foods for improving energy metabolism disorders were summarized. The progress of the application of SIRM on functional foods was elaborated and policy recommendations were also provided. In conclusion, the precise property of SIRM in revealing metabolic pathways will inevitably facilitate the development of functional foods in improving energy metabolism disorders.
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References
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This work was supported by the National Natural Science Foundation of China (82174076), the Construction Project of Liaoning Provincial Key Laboratory, China (2022JH13/10200026), the Fundamental Research Funds for the Central Universities (N2220002) and 111 Project (B16009).
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Yue Hou, Xue-mei Qin, and Dong Liang contributed the central idea. Wenze Wu analyzed most of the data and wrote the initial draft of the paper. The remaining authors contributed to refining the ideas, carrying out additional analyses, and finalizing this paper. All authors reviewed the manuscript.
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Figure. S1. Top 25 most cited keywords of studies on functional foods in energy metabolism from 1995 to 2022. The blue color represents the timespan (1995–2022). The red color represents the year that the keyword appeared Table S1. Top 20 authors of studies on functional foods in energy metabolism from 1995 to 2022. (DOCX 168 KB)
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Wu, W., Meng, Q., Mi, Y. et al. A Novel Strategy for the Development of Functional Foods to Improve Energy Metabolism Disorders: Stable Isotope-Resolved Metabolomics. Food Bioprocess Technol 17, 591–605 (2024). https://doi.org/10.1007/s11947-023-03137-7
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DOI: https://doi.org/10.1007/s11947-023-03137-7