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•• Kohtz AS, Walf AA, Frye CA. Effects of non-contingent cocaine on 3 alpha-androstanediol. II. Disruption of lordosis of proestrous rats. Physiol Behav. 2019;203:113–9. https://doi.org/10.1016/j.physbeh.2017.12.016. The results of this paper showed that cocaine administered in low, medium, or high dosages decreased aggressive behavior among diestrus rats and increased aggressive behavior among proestrus rats. Cocaine, dose dependently, altered estradiol and 3alpha-diol but not testosterone, which correlated with aggression, motor behavior, and sexual responses of female rats.
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Frau R, Mosher LJ, Bini V, Pillolla G, Pes R, Saba P, et al. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating. Psychoneuroendocrinology. 2016;63:59–67. https://doi.org/10.1016/j.psyneuen.2015.09.014.
•• Kohtz AS, Frye CA. Learning and the lifespan: what’s sex got to do with it? Front Neurosci. 2020;14:216. https://doi.org/10.3389/fnins.2020.00216. This paper shows that exposure to mating relevant stimuli following object recognition training enhances performance in the novel object recognition task. Then, mid-aged rats that were sexually responsive had better performance in the novel object recognition task when they were presented with the opportunity to mate in the intertrial interval immediately after training compared to sexually unresponsive mid-aged rats. Cognitive performance in the novel object recognition task correlated with 3alpha-diol levels, suggesting its role in mating and cognitive enhancement.