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Proteomics in Chronic Arthritis—Will We Finally Have Useful Biomarkers?

  • Pediatric Rheumatology (S Ozen, Section Editor)
  • Published:
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Abstract

Purpose of Review

Current technical advances enable the assessment of the complex changes in body fluid proteomes and thus allow for the discovery of biomarker signatures rather than just following differences of a single marker. In this review, we aim to summarize current approaches to discover and evaluate multi-biomarker panels for improved monitoring of chronic arthritis disease activity.

Recent Findings

Mass spectrometry and affinity proteomic methodologies have been used to identify biomarker panels in synovial fluid, serum, plasma, or urine of pediatric and adult chronic arthritis patients. Notably, despite the numerous efforts to develop new and better biomarker panels, very few have undergone extensive analytical and clinical validation and been adopted into routine use for patient benefit.

Summary

There remains a significant gap between discovery of chronic arthritis biomarker signatures and their validation for clinical use.

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Authors and Affiliations

  1. Department of Paediatric Rheumatology and Immunology, University of Muenster, Domagkstraße 3, 48149, Muenster, Germany

    Christoph Kessel, Emely Verweyen, Toni Weinhage, Helmut Wittkowski & Dirk Foell

  2. UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland

    Angela McArdle & Stephen R. Pennington

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  1. Christoph Kessel
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  2. Angela McArdle
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  3. Emely Verweyen
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  4. Toni Weinhage
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  5. Helmut Wittkowski
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  7. Dirk Foell
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Correspondence to Dirk Foell.

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Conflict of Interest

DF declares the receipt of research grant support and honoraria from Pfizer, Novartis, Sobi, and Chugai-Roche. The UCD Conway Institute and Proteomics Core is funded by the Programme for Research in Third level Institutions, as administered by Higher Education Authority of Ireland. Research in SRP’s lab is supported by grants from the Health Research Board, Enterprise Ireland and Science Foundation Ireland and previously including the EU funded FP7 MIAMI project. Dr. Pennington reports role as Founder and CSO of Atturos (www.atturos.com) which is developing prostate cancer multiplexed protein biomarker test on MRM platform. Drs. Kessel and Foell have a patent “means and methods for diagnosing and treating inflammatory disorders” (WO 2016/178154 A1) issued to Muenster University. Dr. Foell has a patent “means and methods for diagnosing and treating inflammatory disorders” (WO 2016/178154 A1) issued to Muenster University. Angela McArdle, Emely Verweyen, Toni Weinhage, and Helmut Wittkowski declare that they have no conflict of interest.

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Kessel, C., McArdle, A., Verweyen, E. et al. Proteomics in Chronic Arthritis—Will We Finally Have Useful Biomarkers?. Curr Rheumatol Rep 20, 53 (2018). https://doi.org/10.1007/s11926-018-0762-0

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