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Endogenous Retrovirus-K and Nervous System Diseases

  • Infection (ML Solbrig, Section Editor)
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Abstract

A new appreciation of the microbiome is changing the way we perceive human health and disease. The holobiontic nature of humans is even etched into our DNA in the form of viral symbionts. Empirical evidence for the presence of endogenous retroviruses (ERVs) in the human genome and their activity in homeostatic and pathologic states has accumulated; however, no causal relationship with human disease has been established to date. In this review, we will focus on the role of endogenous retrovirus-K in neurologic disease. Specifically, we will attempt to reconcile the pathologic contribution of ERVK in disparate neurologic diseases by providing evidence as to inter-individual differences in ERVK genotypes, addressing the molecular regulation of ERVK, and provide detailed examples of ERVK-mediated processes in nervous system diseases.

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Mamneet Manghera and Jennifer Ferguson declare that they have no conflict of interest. Renée Douville has received establishment and operating grants from the Manitoba Health Research Council, an operating grant from the Manitoba Medical Services Foundation, a starter grant from the ALS Association, and major and discretionary awards from the University of Winnipeg.

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  1. Department of Biology, University of Winnipeg, 1RC050, 599 Portage Ave, Winnipeg, Manitoba, Canada, R3B 2G3

    Mamneet Manghera, Jennifer Ferguson & Renée Douville

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  1. Mamneet Manghera
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  2. Jennifer Ferguson
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  3. Renée Douville
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Correspondence to Renée Douville.

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Manghera, M., Ferguson, J. & Douville, R. Endogenous Retrovirus-K and Nervous System Diseases. Curr Neurol Neurosci Rep 14, 488 (2014). https://doi.org/10.1007/s11910-014-0488-y

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