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Urban-Related Environmental Exposures during Pregnancy and Placental Development and Preeclampsia: a Review

  • Preeclampsia (VD Garovic, Section Editor)
  • Published:
Current Hypertension Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To summarize the current knowledge of the pathophysiological implications and the clinical role of urban-related environmental exposures in pregnancy.

Recent Findings

The ongoing urbanization worldwide is leading to an increasing number of pregnant women being exposed to higher levels of urban-related environmental hazards such as air pollution and noise and, at the same time, having less contact with natural environments. Pregnancy represents a particular and vulnerable life period both for women and their children. Extensive physiological and metabolic changes, as well as changes to the cardiovascular and respiratory systems during pregnancy, could result in increased sensitivity to damage by environmental factors.

Summary

Exposure to air pollution and noise is associated with placental dysfunction and damage, which, in turn, could lead to maternal complications such as preeclampsia. In contrast, more contact with greenspace during pregnancy seems to mitigate these adverse impacts. These findings open up new challenges for our understanding of the potential effect of urban living on placental function and preeclampsia, and offer new clinical and research opportunities.

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Funding

Payam Dadvand is funded by Ramón y Cajal fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Competitiveness. Maria Foraster is supported by a Beatriu de Pinós fellowship [2018/8374/I] awarded by the Universities and Research Secretariat of the Catalan Ministry of Business and Knowledge. Maria Torres Toda is funded by a PFIS (Contrato Predoctoral de Formación en Investigación en Salud) fellowship (FI17/00128) awarded by Instituto de Salud Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.

Author information

Author notes

  1. María Julia Zanini and Carla Domínguez contributed equally to this work.

Authors and Affiliations

  1. Obstetrics and Gynecology Department, High Risk Unit, Sant Pau University Hospital, C/Sant Quintí, 89, 08041, Barcelona, Spain

    María Julia Zanini, Carla Domínguez, Toni Fernández-Oliva, Olga Sánchez & Elisa Llurba

  2. Women and Perinatal Health Research Group, Biomedical Research Institute Sant Pau (IIB-SantPau), Sant Pau University Hospital, Barcelona, Spain

    María Julia Zanini, Carla Domínguez, Toni Fernández-Oliva, Olga Sánchez & Elisa Llurba

  3. School of Medicine, UniversitatAutònoma de Barcelona, Barcelona, Spain

    María Julia Zanini, Carla Domínguez, Toni Fernández-Oliva, Olga Sánchez & Elisa Llurba

  4. Maternal and Child Health and Development Network (SAMID), RD16/0022/0015, Instituto de Salud Carlos III, Barcelona, Spain

    Olga Sánchez & Elisa Llurba

  5. ISGlobal, 08003, Barcelona, Spain

    María Torres Toda, María Foraster & Payam Dadvand

  6. Universitat Pompeu Fabra (UPF), 08002, Barcelona, Spain

    María Torres Toda, María Foraster & Payam Dadvand

  7. CIBER Epidemiología y SaludPública (CIBERESO), 28029, Madrid, Spain

    María Torres Toda, María Foraster & Payam Dadvand

Authors
  1. María Julia Zanini
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  2. Carla Domínguez
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  3. Toni Fernández-Oliva
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  4. Olga Sánchez
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  5. María Torres Toda
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  6. María Foraster
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  7. Payam Dadvand
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  8. Elisa Llurba
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Corresponding author

Correspondence to Elisa Llurba.

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This article is part of the Topical Collection on Preeclampsia

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Zanini, M.J., Domínguez, C., Fernández-Oliva, T. et al. Urban-Related Environmental Exposures during Pregnancy and Placental Development and Preeclampsia: a Review. Curr Hypertens Rep 22, 81 (2020). https://doi.org/10.1007/s11906-020-01088-4

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