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Does Rituximab Have a Place in Treating Classic Hodgkin Lymphoma?

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Abstract

Monoclonal antibodies targeting surface proteins on the malignant Hodgkin and Reed-Sternberg (HRS) cells are currently under intensive investigation with promising early results. Of particular interest is the CD20 antigen, because it is expressed not only on a small fraction of HRS cells but also on the benign reactive B cells in the microenvironment. The rationale of using rituximab in classic Hodgkin lymphoma (cHL) comprises several points: 1) HRS cells infrequently express CD20; 2) elimination of CD20-positive reactive B cells supporting HRS cells would deprive the malignant cells of survival signals; 3) elimination of reactive B cells may also potentially increase host immune response against HRS cells; 4) HRS stem cells express CD20. Although this rationale has not generally been confirmed in patients, promising results in managing cHL have occurred in early-phase clinical trials of rituximab, including trials of rituximab as a single agent in refractory or recurrent cHL, rituximab plus gemcitabine in refractory or recurrent cHL, and rituximab plus ABVD in newly diagnosed cHL. Based on the results of these trials, several prospective clinical trials using rituximab in the management of advanced-stage cHL and early-stage cHL are ongoing. These trials further clarify the role of rituximab in cHL. Enrollment of patients with this “classic” disease in clinical trials is encouraged.

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Disclosure

Dr. Younes has received consulting fees and honoraria from Boehringer Ingelheim, Novartis, Sandoz, Trubion, Amgen, Abbott Oncology, Genentech, Biogen Idec, Seattle Genetics, Methylgene, Pharmion, Sanofi-Aventis, Xencor, Tiba Oncology, Allos Therapeutics, Syndax, Italfarmaco, and GlaxoSmithKline. No other potential conflicts of interest relevant to this article were reported.

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  1. Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 429, Houston, TX, 77030, USA

    Yasuhiro Oki & Anas Younes

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  1. Yasuhiro Oki
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  2. Anas Younes
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Correspondence to Anas Younes.

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Oki, Y., Younes, A. Does Rituximab Have a Place in Treating Classic Hodgkin Lymphoma?. Curr Hematol Malig Rep 5, 135–139 (2010). https://doi.org/10.1007/s11899-010-0052-z

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