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Treatment of classical Hodgkin lymphoma in the era of brentuximab vedotin and immune checkpoint inhibitors

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Abstract

The majority of Hodgkin lymphoma patients are now cured with conventional first-line therapy; however, 10–15% of early-stage disease and less than 30% of advanced-stage patients are refractory(rare) or relapsed. Salvage second-line therapy combined with high-dose therapy and autologous stem-cell transplantation can cure 40–50% of patients. Recently novel agents (Brentuximab Vedotin and Immune Checkpoint inhibitors) have demonstrated evidence of therapeutic activity and are potential bridge to an allogeneic stem-cell transplantation. The review is aimed to present not only salvage strategies; indeed, the paper contains paragraphs about therapy and new treatment options at diagnosis.

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Authors and Affiliations

  1. Division of Hematology and BMT Unit, Ospedale Policlinico San Martino, Genoa, Italy

    A. M. Carella

  2. Division of Hematology and BMT Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    P. Corradini, A. Mussetti & S. Viviani

  3. Department of Oncology, Università di Torino, Turin, Italy

    U. Ricardi

  4. AOU Citta’ della Salute e della Scienza, Turin, Italy

    U. Vitolo

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  1. A. M. Carella
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  2. P. Corradini
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  3. A. Mussetti
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  4. U. Ricardi
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  5. U. Vitolo
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Correspondence to A. M. Carella.

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Carella AM: No conflict of interest; Corradini P.: Speaker Honoraria: Novartis, Celgene, Janssen, Gilead; Mussetti A.: no conflict of interest; Ricardi U.: no conflict of interest; Vitolo U.: Roche, Celgene, Janssen, Gilead, Takeda; Viviani S.: Takeda International: Consultancy, Research funding; Takeda Italia SpA: Speakers bureau, Travel and Accommodation expenses; Italfarmaco Consultancy.

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Carella, A.M., Corradini, P., Mussetti, A. et al. Treatment of classical Hodgkin lymphoma in the era of brentuximab vedotin and immune checkpoint inhibitors. Ann Hematol 97, 1301–1315 (2018). https://doi.org/10.1007/s00277-018-3366-x

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