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Biomarkers in Sleep Apnea and Heart Failure

  • Biomarkers of Heart Failure (W.H.W. Tang and J.L. Grodin, Section Editors)
  • Published:
Current Heart Failure Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Sleep-disordered breathing (SDB) is highly prevalent in heart failure (HF) and may confer significant stress to the cardiovascular system and increases the risk for future cardiovascular events. The present review will provide updates on the current understanding of the relationship of SDB and common HF biomarkers and the effect of positive airway pressure therapy on these biomarkers, with particular emphasis in patients with coexisting SDB and HF.

Recent Findings

Prior studies have examined the relationship between HF biomarkers and SDB, and the effect of SDB treatment on these biomarkers, with less data available in the context of coexisting SDB and HF. Overall, however, the association of SDB and circulating biomarkers has been inconsistent.

Summary

Further research is needed to elucidate the relationship between biomarkers and SDB in HF, to evaluate the clinical utility of biomarkers over standard methods in large, prospective studies and also to assess the impact of treatment of SDB on these biomarkers in HF via interventional studies.

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Authors and Affiliations

  1. Sleep Care Solutions, 1835 Yonge Street, Suite 303, Toronto, Ontario, M4S 1X8, Canada

    Ying Y. Zhao

  2. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Reena Mehra

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  1. Ying Y. Zhao
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Correspondence to Ying Y. Zhao.

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Ying Y. Zhao declares no conflict of interests.

Reena Mehra received grants from NIH, royalties from Up to Date, an honorarium from American Academy of Sleep Medicine, non-financial support from Resmed, and non-financial support from Philips Respironics.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Biomarkers of Heart Failure

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Zhao, Y.Y., Mehra, R. Biomarkers in Sleep Apnea and Heart Failure. Curr Heart Fail Rep 14, 284–300 (2017). https://doi.org/10.1007/s11897-017-0339-7

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