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NT-pro-BNP in obstructive sleep apnea syndrome is decreased by nasal continuous positive airway pressure

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Summary

Objective

The aim of this study was to evaluate the impact of obstructive sleep apnea syndrome (OSAS) on B-type natriuretic peptide (BNP) and to determine the effect of nasal continuous positive airway pressure (nCPAP) treatment on BNP levels.

Background

Increased sympathetic activity, repetitive rises in blood pressure, and apnea-induced wall stress may contribute as a trigger to release BNP in OSAS. However, there is uncertainty about whether OSAS affects BNP and whether application of nasal continuous positive airway pressure (nCPAP) ventilation affects release of BNP.

Patients and methods

A prospective study in 69 consecutive patients with suspected sleep disordered breathing referred to our sleep laboratory was conducted. OSAS was confirmed in 26 normotensive and 34 hypertensive patients and ruled out in nine normotensive patients (controls) by polysomnography (PSG).

Results

Baseline N-terminal fragment of BNP prohormone (NT-pro-BNP) did not differ significantly between OSAS patients (hypertensive: mean ±SEM 60.8±9.9 pg/ml, normotensive: 43.2±6.8 pg/ml) and controls (36.5±8.5 pg/ml). Application of CPAP resulted in a significant decrease of NT-pro-BNP in hypertensive (60.8±9.9 pg/ml to 47.6±7.4 pg/ml, p=0.023) and normotensive OSAS (43.2±6.8 pg/ml to 29.6±5.3 pg/ml, p=0.0002). In contrast, controls showed no significant differences in NT-pro-BNP after a second PSG (36.5±8.5 pg/ml to 40.7±12.3 pg/ml, p=0.597).

Conclusions

Normotensive and hypertensive OSAS was not associated with a significant elevation of NT-pro-BNP. Application of nCPAP decreased NT-pro-BNP levels significantly in normotensive and, in particular, hypertensive OSAS. These findings may provide further evidence of the potential for nCPAP to improve cardiovascular comorbidity and co-mortality in OSAS and sleep disordered breathing, in general.

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Authors and Affiliations

  1. Department of Internal Medicine II, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    S. Tasci*, R. Manka*, S. Scholtyssek, S. Lentini, C. Troatz & B. Lüderitz

  2. Department of Clinical Biochemistry, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    B. Stoffel-Wagner

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  1. S. Tasci*
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  2. R. Manka*
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Correspondence to S. Tasci*.

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* These authors contributed equally to this work

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Tasci*, S., Manka*, R., Scholtyssek, S. et al. NT-pro-BNP in obstructive sleep apnea syndrome is decreased by nasal continuous positive airway pressure. Clin Res Cardiol 95, 23–30 (2006). https://doi.org/10.1007/s00392-006-0315-9

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  • DOI: https://doi.org/10.1007/s00392-006-0315-9

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