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Update on the Mechanisms of Gastric Acid Secretion

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Abstract

Acid-related disorders represent a major healthcare concern. In recent years, our understanding of the physiologic processes underlying gastric acid secretion has improved notably. The identity of several apical ion transport proteins, which are necessary for acid secretion to take place, has been resolved. The recent developments have uncovered potential therapeutic targets for the treatment of acid-related disorders. This brief review provides an update on the mechanisms of gastric acid secretion, with a particular focus on apical ion transport.

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Disclosure

Conflicts of interest: Dr. Kopic: none. Dr. Geibel has received honoraria from Amgen and has stock/stock options in Ardelyx; Dr. Geibel’s institution has received grant support from the Bill and Melinda Gates Foundation, and has patents (planned, pending, or issued) for Amgen.

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  1. Departments of Surgery and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA

    Sascha Kopic

  2. Department of Surgery, Yale School of Medicine, 310 Cedar Street, BML 265, New Haven, 06510, CT, USA

    John P. Geibel

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  1. Sascha Kopic
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Correspondence to John P. Geibel.

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Kopic, S., Geibel, J.P. Update on the Mechanisms of Gastric Acid Secretion. Curr Gastroenterol Rep 12, 458–464 (2010). https://doi.org/10.1007/s11894-010-0137-9

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