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Mesenchymal Stromal Cell Exosomes in Cardiac Repair

  • Regenerative Medicine (SM Wu, Section Editor)
  • Published:
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Abstract

Purpose of the Review

Mesenchymal stromal cells (MSCs) are considered an attractive option for cell-based therapy because of their immune-privileged phenotype and paracrine activity. Substantial preclinical evidence indicates that MSC exosomes recapitulate MSC cellular function in cardiac regeneration and repair. Therefore, in this review, we briefly discuss the latest research progress of MSC exosomes in cardiac repair and regeneration.

Recent Findings

The recent revolutionary advance in controlling the contents of the exosomes by manipulating parental cells through bioengineering methods to alter specific signaling pathways in ischemic myocardium has proven to be beneficial in the treatment of heart failure.

Summary

MSC Exosomes appear to be leading candidates to treat myocardial infarction and subsequent heart failure by carrying rich cargo from their parental cells. However, more clinical and pre-clinical studies on MSC exosomes will be required to confirm the beneficial effect to treat cardiovascular diseases

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Fig. 1

source of MSCs carry and deliver proteins, nucleic acids (DNA, miRNAs, mRNAs, and other RNAs), and metabolites to the damage heart tissue, consequently promoting cardioprotective effects

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Funding

This article was partially supported by the National Institute of Health grants HL091983, HL143892, HL134608, and HL147841.

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Authors and Affiliations

  1. Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, MERB‐953, 3500 N Broad Street, Philadelphia, PA, 19140, USA

    Darukeshwara Joladarashi & Raj Kishore

  2. Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA

    Raj Kishore

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  1. Darukeshwara Joladarashi
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Correspondence to Raj Kishore.

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Joladarashi, D., Kishore, R. Mesenchymal Stromal Cell Exosomes in Cardiac Repair. Curr Cardiol Rep 24, 405–417 (2022). https://doi.org/10.1007/s11886-022-01660-1

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