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Preparation and application of highly porous aerogel-based bioactive materials in dentistry

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Abstract

In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and β-tricalcium phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in the mesoporous region with a maximum pore diameter of 7.4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scanning electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy.

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References

  1. Lázár I, Manó S, Jónás Z, et al. Mesoporous silica-calcium phosphate composites for experimental bone substitution. Biomechanica Hungarica, 2010, III. 1: 151–158

    Google Scholar 

  2. Dorozhkin S V. Calcium orthophosphates in dentistry. Journal of Materials Science: Materials in Medicine, 2013, 24(6): 1335–1363

    Google Scholar 

  3. Dorozhkin S V. Calcium orthophosphate cements for biomedical application. Journal of Materials Science, 2008, 43(9): 3028–3057

    Article  Google Scholar 

  4. Dorozhkin S V. Biphasic, triphasic and multiphasic calcium orthophosphates. Acta Biomaterialia, 2012, 8(3): 963–977

    Article  Google Scholar 

  5. Monchau F, Hivart P, Genesite B, et al. Calcite as a bone substitute. Comparsion with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity. Materials Science and Engineering C, 2013, 33(1): 490–498

    Article  Google Scholar 

  6. Hench L L. Bioceramics. Journal of the American Ceramic Society, 1998, 81(7): 1705–1728

    Article  Google Scholar 

  7. Gittings J P, Bowen C R, Dent A C, et al. Electrical characterization of hydroxyapatite-based bioceramics. Acta Biomaterialia, 2009, 5(2): 743–754

    Article  Google Scholar 

  8. Rezwan K, Chen Q Z, Blaker J J, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006, 27(18): 3413–3431

    Article  Google Scholar 

  9. Hench L L. Bioceramics: from concept to clinic. Journal of the American Ceramic Society, 1991, 74(7): 1487–1510

    Article  Google Scholar 

  10. Silver I A, Deas J, Erecińska M. Interactions of bioactive glasses with osteoblasts in vitro: effects of 45S5 Bioglass®, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability. Biomaterials, 2001, 22(2): 175–185

    Article  Google Scholar 

  11. Ohtsuki C, Kamitakahara M, Miyazaki T. Bioactive ceramicbased materials with designed reactivity for bone tissue regeneration. Journal of the Royal Society, Interface, 2009, 6 (Suppl 3): S349–S360

    Article  Google Scholar 

  12. Liu X, Morra M, Carpi A, et al. Bioactive calcium silicate ceramics and coatings. Biomedicine & Pharmacotherapy, 2008, 62 (8): 526–529

    Article  Google Scholar 

  13. Lee E J, Shin D S, Kim H E, et al. Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. Biomaterials, 2009, 30(5): 743–750

    Article  Google Scholar 

  14. Balamurugan A, Rebelo A H S, Lemos A F, et al. Suitability evaluation of sol-gel derived Si-substituted hydroxyapatite for dental and maxillofacial applications through in vitro osteoblasts response. Dental Materials, 2008, 24(10): 1374–1380

    Article  Google Scholar 

  15. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26(27): 5474–5491

    Article  Google Scholar 

  16. Sing K S V, Everett D H, Haul R A W, et al. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity. Pure and Applied Chemistry, 1985, 57(4): 603–619

    Article  Google Scholar 

  17. Tuan R S. Role of adult stem/progenitor cells in osseointegration and implant loosening. International Journal of Oral & Maxillofacial Implants, 2011, 26(Suppl): 50–62, discussion 63–69

    Google Scholar 

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Correspondence to Csaba Hegedüs.

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Kuttor, A., Szalóki, M., Rente, T. et al. Preparation and application of highly porous aerogel-based bioactive materials in dentistry. Front. Mater. Sci. 8, 46–52 (2014). https://doi.org/10.1007/s11706-014-0231-2

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  • DOI: https://doi.org/10.1007/s11706-014-0231-2

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