Abstract
This chapter is an introduction to nanocomposite materials and its classifications with emphasis on orthopedic application. It covers different types of matrix nanocomposites including ceramics, metal, polymer and natural-based nanocomposites with the main features and applications in the orthopedic. In addition, it presents structure, composition, and biomechanical features of bone as a natural nanocomposite. Finally, it deliberately presents developing methods for nanocomposites bone grafting.
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Henrique P, Camargo C, Satyanarayana K G, Wypych F. Nanocomposites: Synthesis, structure, properties and new application opportunities. Materials Research, 2009, 12(1): 1–39
Mittal V. Bio–nanocomposites: Future high–value materials. In: Nanocomposites with Biodegradable Polymers: Synthesis, Properties, and Future perspectives. Oxford, 2011, 1–27
Schmidt D, Shah D, Giannelis E P. New advances in polymer/layered silicate nanocomposites. Current Opinion in Solid State and Materials Science, 2002, 6(3): 205–212
Lau A K T, Bhattacharyya D, Ling C H Y. Nanocomposites for engineering applications. Journal of Nanomaterials, 2009, 2009: 1
Tjong S C. Polymer Composites With Carbonaceous Nanofillers: Properties and Applications. Hoboken: Wiley, 2012, 1–388
Murugan R, Ramakrishna S. Development of nanocomposites for bone grafting. Composites Science and Technology, 2005, 65(15–16): 2385–2406
Johnell O. The socioeconomic burden of fractures: Today and in the 21st century. American Journal of Medicine, 1997, 103(2): 20S–26S
Jones L C, Topoleski L D T, Tsao A K. Biomaterials in orthopaedic implants. In: Mechanical Testing of Orthopaedic Implants. Amsterdam: Elsevier, 2017, 17–32
Liu H, Webster T J. Bioinspired nanocomposites for orthopedic applications. Nanotechnology for the regeneration of hard and soft tissues. Singapore: World Scientific, 2007, 1–52
Gu Y, Chen X, Lee J H, Monteiro D A, Wang H, Lee W Y. Inkjet printed antibiotic–and calcium–eluting bioresorbable nanocomposite micropatterns for orthopedic implants. Acta Biomaterialia, 2012, 8(1): 424–431
Chan C K, Kumar T S S, Liao S, Murugan R, Ngiam M, Ramakrishnan S. Biomimetic nanocomposites for bone graft applications. Future Nanomedicine, 2006, 1(2): 177–188
Okpala C C. Nanocomposites–an overview. International Journal of Engineering Research and Development, 2013, 8(11): 17–23
Yang C, Wei H, Guan L, Guo J, Wang Y, Yan X, Zhang X, Wei S, Guo Z. Polymer nanocomposites for energy storage, energy saving, and anticorrosion. Journal of Materials Chemistry. A, Materials for Energy and Sustainability, 2015, 3(29): 14929–14941
Petronella F, Truppi A, Ingrosso C, Placido T, Striccoli M, Curri M L, Agostiano A, Comparelli R. Nanocomposite materials for photocatalytic degradation of pollutants. Catalysis Today, 2017, 281: 85–100
Duan X, Deng J, Wang X, Liu P. Preparation of rGO/G/PANI ternary nanocomposites as high performance electrode materials for supercapacitors with spent battery powder as raw material. Materials & Design, 2017, 129: 135–142
Tai WP, Kim Y S, Kim J G. Fabrication and magnetic properties of Al2O3/Co nanocomposites. Materials Chemistry and Physics, 2003, 82(2): 396–400
Russo T, Gloria A, De Santis R, D’Amora U, Balato G, Vollaro A, Oliviero O, Improta G, Triassi M, Ambrosio L. Preliminary focus on the mechanical and antibacterial activity of a PMMA–based bone cement loaded with gold nanoparticles. Bioactive Materials, 2017, 2(3): 156–161
Duc N D, Seung–Eock K, Quan T Q, Long D D, Anh V M. Nonlinear dynamic response and vibration of nanocomposite multilayer organic solar cell. Composite Structures, 2018, 184: 1137–1144
Khalid A, Abdel–Karim A, Ali Atieh M, Javed S, McKay G. PEGCNTs nanocomposite PSU membranes for wastewater treatment by membrane bioreactor. Separation and Purification Technology, 2018, 190: 165–176
Schmidt D, Shah D, Giannelis E P. New advances in polymer/layered silicate nanocomposites. Current Opinion in Solid State and Materials Science, 2002, 6(3): 205–212
Seo WJ, Sung Y T, Kim S B, Lee Y B, Choe K H, Choe S H, Sung J Y, Kim W N. Effects of ultrasound on the synthesis and properties of polyurethane foam/clay nanocomposites. Journal of Applied Polymer Science, 2006, 102(4): 3764–3773
Vallet–Regí M, González–Calbet J M. Calcium phosphates as substitution of bone tissues. Progress in Solid State Chemistry, 2004, 32(1–2): 1–31
Ramay H R R, Zhang M. Biphasic calcium phosphate nanocomposite porous scaffolds for load–bearing bone tissue engineering. Biomaterials, 2004, 25(21): 5171–5180
Swain S K, Gotman I, Unger R, Gutmanas E Y. Bioresorbable β–TCP–FeAg nanocomposites for load bearing bone implants: High pressure processing, properties and cell compatibility. Materials Science and Engineering C, 2017, 78: 88–95
Chernousova S, Epple M. Silver as antibacterial agent: Ion, nanoparticle, and metal. Angewandte Chemie International Edition, 2012, 52(6): 1636–1653
Porwal H, Saggar R. Ceramic Matrix Nanocomposites. In: Comprehensive Composite Materials. Amsterdam: Elsevier, 2017, 138–161
Gupta P, Kumar D, Quraishi M A, Parkash O. Metal matrix nanocomposites and their application in corrosion control. Berlin: Springer, 2016, 231–246
Kheimehsari H, Izman S, Shirdar M R. Effects of HA–coating on the surface morphology and corrosion behavior of a Co–Cr–based implant in different conditions. Journal of Materials Engineering and Performance, 2015, 24(6): 2294–2302
Taheri M M, Kadir M R A, Shokuhfar T, Hamlekhan A, Assadian M, Shirdar M R, Mirjalili A. Surfactant–assisted hydrothermal synthesis of fluoridated hydroxyapatite nanorods. Ceramics International, 2015, 41(8): 9867–9872
Balani K, Chen Y, Harimkar S P, Dahotre N B, Agarwal A. Tribological behavior of plasma–sprayed carbon nanotube–reinforced hydroxyapatite coating in physiological solution. Acta Biomaterialia, 2007, 3(6): 944–951
Shirdar M R, Taheri M M. Surface morphology and corrosion behavior of hydroxyapatite–coated Co–Cr implant: Effect of sintering conditions. Journal of the Minerals Metals & Materials Society, 2017, 69(12): 2831–2837
Taheri M M, Kadir M R A, Shokuhfar T, Hamlekhan A, Shirdar M R, Naghizadeh F. Fluoridated hydroxyapatite nanorods as novel fillers for improving mechanical properties of dental composite: Synthesis and application. Materials & Design, 2015, 82: 119–125
Dorozhkin S. Bioceramics of calcium orthophosphates. Biomaterials, 2010, 31(7): 1465–1485
Sivaperumal V R, Mani R, Nachiappan M S, Arumugam K. Direct hydrothermal synthesis of hydroxyapatite/alumina nanocomposite. Materials Characterization, 2017, 134: 416–421
Singh MK, Shokuhfar T, Gracio J J de A, de Sousa A C M, Fereira J M D F, Garmestani H, Ahzi S. Hydroxyapatite modified with carbon–nanotube–reinforced poly(methyl methacrylate): A nanocomposite material for biomedical applications. Advanced Functional Materials, 2008, 18(5): 694–700
Farrokhi–Rad M. Electrophoretic deposition of fiber hydroxyapatite/titania nanocomposite coatings. Ceramics International, 2017, 44(1): 622–630
Shirdar M R, Sudin I, Taheri M M, Keyvanfar A, Yusop M Z M. A novel hydroxyapatite composite reinforced with titanium nanotubes coated on Co–Cr–based alloy. Vacuum, 2015, 122: 82–89
Henderson H B, Rios O, Bryan Z L, Heitman C P K, Ludtka G M, Mackiewicz–Ludtka G, Melin A M, Manuel M V. Magnetoacoustic mixing technology: A novel method of processing metalmatrix nanocomposites. Advanced Engineering Materials, 2014, 16(9): 1078–1082
Li X, Xu J. Metal matrix nanocomposites. In: Comprehensive Composite Materials II. Amsterdam: Elsevier, 2018, 97–137
Janas D, Liszka B. Copper matrix nanocomposites based on carbon nanotubes or graphene. Materials Chemistry Frontiers, 2018, 2(1): 22–35
Hassanzadeh–Aghdam M K, Mahmoodi M J. A comprehensive analysis of mechanical characteristics of carbon nanotube–metal matrix nanocomposites. Materials Science and Engineering A, 2017, 701: 34–44
Yahata C, Mochizuki A. Platelet compatibility of magnesium alloys. Materials Science and Engineering C, 2017, 78: 1119–1124
Witte F, Eliezer A. Biodegradable metals. In: Degradation of Implant Materials. Berlin: Springer, 2012, 93–110
Song G. Control of biodegradation of biocompatable magnesium alloys. Corrosion Science, 2007, 49(4): 1696–1701
Khalajabadi S Z, Abu A B H, Ahmad N, Kadir M R A, Ismail A F, Nasiri R, Haider W, Redzuan N B H. Biodegradable Mg/HA/TiO2 nanocomposites coated with MgO and Si/MgO for orthopedic applications: A study on the corrosion, surface characterization, and biocompatability. Coatings, 2017, 7(7): 154
Zhu C, Lv Y, Qian C, Qian H, Jiao T, Wang L, Zhang F. Proliferation and osteogenic differentiation of rat BMSCs on a novel Ti/SiC metal matrix nanocomposite modified by friction stir processing. Scientific Reports, 2016, 6(1): 38875
Zhu C, Lv Y, Qian C, Ding Z, Jiao T, Gu X, Lu E, Wang L, Zhang F. Microstructures, mechanical, and biological properties of a novel Ti–6V–4V/zinc surface nanocomposite prepared by friction stir processing. International Journal of Nanomedicine, 2018, 13: 1881–1898
De Journett T J, Spicer J B. Synthesis and patterning of polymer matrix nanocomposites using femtosecond laser–assisted processing. Materials Research Society, 2012, 1455, mrss12–1455–ii02–03
Zare Y, Shabani I. Polymer/metal nanocomposites for biomedical applications. Materials Science and Engineering C, 2016, 60: 195–203
Dubey S P, Thakur V K, Krishnaswamy S, Abhyankar H A, Marchante V, Brighton J L. Progress in environmental–friendly polymer nanocomposite material from PLA: Synthesis, processing and applications. Vacuum, 2017, 146: 655–663
Palmero P. Ceramic–polymer nanocomposites for bone–tissue regeneration. In: Nanocomposites for Musculoskeletal Tissue Regeneration. Amsterdam: Elsevier, 2016, 331–367
Hule R A, Pochan D J. Polymer nanocomposites for biomedical applications. MRS Bulletin, 2007, 32(4): 354–358
Mansur H S, Costa H S. Nanostructured poly(vinyl alcohol)/bioactive glass and poly(vinyl alcohol)/chitosan/bioactive glass hybrid scaffolds for biomedical applications. Chemical Engineering Journal, 2008, 137(1): 72–83
Mohanapriya S, Mumjitha M, Purnasai K, Raj V. Fabrication and characterization of poly(vinyl alcohol)–TiO2 nanocomposite films for orthopedic applications. Journal of the Mechanical Behavior of Biomedical Materials, 2016, 63: 141–156
Kim H W, Lee H H, Knowles J C. Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration. Journal of Biomedical Materials Research. Part A, 2006, 79A(3): 643–649
Liao S S, Cui F Z, Zhang W, Feng Q L. Hierarchically biomimetic bone scaffold materials: Nano–HA/collagen/PLA composite. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2004, 69B(2): 158–165
Chan K, Wong H, Yeung K, Tjong S. Polypropylene biocomposites with boron nitride and nanohydroxyapatite reinforcements. Materials (Basel), 2015, 8(3): 992–1008
Wei G, Ma P X. Nanostructured biomaterials for regeneration. Advanced Functional Materials, 2008, 18(22): 3568–3582
Webster T J, Ahn E S. Nanostructured biomaterials for tissue engineering bone. Advances in Biochemical Engineering/Biotechnology, 2007, 103: 275–308
Pina S, Oliveira J M, Reis R L. Natural–based nanocomposites for bone tissue engineering and regenerative medicine: A review. Advanced Materials, 2015, 27(7): 1143–1169
Kumar C S S R. Biomimetic and Bioinspired Nanomaterials. Hoboken: Wiley, 2010, 1–586
Canillas M, Pena P, de Aza A H, Rodríguez M A. Calcium phosphates for biomedical applications. Boletín de la Sociedad Española de Cerámica y Vidrio, 2017, 56(3): 91–112
Park S, Lih E, Park K S, Joung Y K, Han D K. Bin, Lih E, Park K S, Joung Y K, Han D K. Biopolymer–based functional composites for medical applications. Progress in Polymer Science, 2017, 68: 77–105
Cunniffe G M, Dickson G R, Partap S, Stanton K T, O’Brien J F. Development and characterisation of a collagen nano–hydroxyapatite composite scaffold for bone tissue engineering. Journal of Materials Science. Materials in Medicine, 2010, 21(8): 2293–2298
Yan L P, Silva–Correia J, Correia C, Caridade S G, Fernandes E M, Sousa R A, Mano J F, Oliveira J M, Oliveira A L, Reis R L. Bioactive macro/micro porous silk fibroin/nano–sized calcium phosphate scaffolds with potential for bone–tissue–engineering applications. Nanomedicine (London), 2013, 8(3): 359–378
Barbani N, Guerra G D, Cristallini C, Urciuoli P, Avvisati R, Sala A, Rosellini E. Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction. Journal of Materials Science. Materials in Medicine, 2012, 23(1): 51–61
Rogel M R, Qiu H, Ameer G A. The role of nanocomposites in bone regeneration. Journal of Materials Chemistry, 2008, 18(36): 4233
Bhattacharyya S, Kumbar S G, Khan Y M, Nair L S, Singh A, Krogman N R, Brown P W, Allcock H R, Laurencin C T. Biodegradable polyphosphazene–nanohydroxyapatite composite nanofibers: Scaffolds for bone tissue engineering. Journal of Biomedical Nanotechnology, 2009, 5(1): 69–75
Porter D. Pragmatic multiscale modelling of bone as a natural hybrid nanocomposite. Materials Science and Engineering A, 2004, 365(1–2): 38–45
Boyle WJ, Simonet WS, Lacey D L. Osteoclast differentiation and activation. Nature, 2003, 423(6937): 337–342
Dorozhkin S V. Calcium Orthophosphate–based Bioceramics and Biocomposites. Hoboken: Wiley, 2016, 1–405
Landis WJ. The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone, 1995, 16(5): 533–544
Rho J Y, Kuhn–Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Medical Engineering & Physics, 1998, 20(2): 92–102
Kumar G, Narayan B. Morbidity at bone graft donor sites. In: Classic Papers in Orthopaedics. Berlin: Springer, 2014, 503–505
García–Gareta E, Coathup M J, Blunn G W. Osteoinduction of bone grafting materials for bone repair and regeneration. Bone, 2015, 81: 112–121
Liu Y, Liu S, Luo D, Xue Z, Yang X, Gu L, Zhou Y, Wang T. Hierarchically staggered nanostructure of mineralized collagen as a bone–grafting scaffold. Advanced Materials, 2016, 28(39): 8740–8748
Becker J, Lu L, Runge M B, Zeng H, Yaszemski M J, Dadsetan M. Nanocomposite bone scaffolds based on biodegradable polymers and hydroxyapatite. Journal of Biomedical Materials Research. Part A, 2015, 103(8): 2549–2557
Hickey D J, Ercan B, Sun L, Webster T J. Adding MgO nanoparticles to hydroxyapatite–PLLA nanocomposites for improved bone tissue engineering applications. Acta Biomaterialia, 2015, 14: 175–184
Atak B H, Buyuk B, Huysal M, Isik S, Senel M, Metzger W, Cetin G. Preparation and characterization of amine functional nanohydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications. Carbohydrate Polymers, 2017, 164: 200–213
Liao S, Ngiam M, Chan C K, Ramakrishna S. Fabrication of nano hydroxyapatite/collagen/osteonectin composites for bone graft applications. Biomedical Materials (Bristol, England), 2009, 4 (2): 25019
Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J. Selforganization mechanism in a bone–like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials, 2001, 22(13): 1705–1711
Chan C K, Kumar T S, Liao S, Murugan R, Ngiam M, Ramakrishnan S. Biomimetic nanocomposites for bone graft applications. Nanomedicine (London), 2006, 1(2): 177–188
Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26(27): 5474–5491
Salgado A J, Coutinho O P, Reis R L. Bone tissue engineering: State of the art and future trends. Macromolecular Bioscience, 2004, 4(8): 743–765
Chan B P, Hui T Y, Wong M Y, Yip K H K, Chan G C F. Mesenchymal stem cell–encapsulated collagen microspheres for bone tissue engineering. Tissue Engineering. Part C, Methods, 2010, 16(2): 225–235
Schieker M, Seitz H, Drosse I, Seitz S, Mutschler W. Biomaterials as scaffold for bone tissue engineering. European Journal of Trauma, 2006, 32(2): 114–124
Sachlos E, Czernuszka J T. Making tissue engineering scaffolds work. Review: The application of solid freeform fabrication technology to the production of tissue engineering scaffolds. European Cells & Materials, 2003, 5: 29–40
Hayashi T. Biodegradable polymers for biomedical uses. Progress in Polymer Science, 1994, 19(4): 663–702
Winter G D. Heterotopic bone formation in a synthetic sponge. Proceedings of the Royal Society of Medicine, 1970, 63: 1111–1115
Blokhuis T J, Termaat M F, den Boer F C, Patka P, Bakker F C, Haarman H J. Properties of calcium phosphate ceramics in relation to their in vivo behavior. Journal of Trauma, 2000, 48(1): 179–186
Chan O, Coathup M J, Nesbitt A, Ho C Y, Hing K A, Buckland T, Campion C, Blunn G W. The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials. Acta Biomaterialia, 2012, 8(7): 2788–2794
Wang J, Chen Y, Zhu X, Yuan T, Tan Y, Fan Y, Zhang X. Effect of phase composition on protein adsorption and osteoinduction of porous calcium phosphate ceramics in mice. Journal of Biomedical Materials Research. Part A, 2014, 102(12): 4234–4243
Bi L, Jung S, Day D, Neidig K, Dusevich V, Eick D, Bonewald L. Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical–sized rat calvarial defects implanted with bioactive glass scaffolds. Journal of Biomedical Materials Research. Part A, 2012, 100(12): 3267–3275
Klopčič S B, Kovač J, Kosmač T. Apatite–forming ability of alumina and zirconia ceramics in a supersaturated Ca/P solution. Biomolecular Engineering, 2007, 24(5): 467–471
Matassi F, Botti A, Sirleo L, Carulli C, Innocenti M. Porous metal for orthopedics implants. Clinical Cases in Mineral and Bone Metabolism, 2013, 10(2): 111–115
Thomann M, Krause C, Angrisani N, Bormann D, Hassel T, Windhagen H, Meyer–Lindenberg A. Influence of a magnesiumfluoride coating of magnesium–based implants (MgCa0.8) on degradation in a rabbit model. Journal of Biomedical Materials Research. Part A, 2010, 93(4): 1609–1619
Kasuga T, Maeda H, Kato K, Nogami M, Hata K I, Ueda M. Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite). Biomaterials, 2003, 24(19): 3247–3253
Fricain J C, Schlaubitz S, Le Visage C, Arnault I, Derkaoui S M, Siadous R, Catros S, Lalande C, Bareille R, Renard M, et al. A nano–hydroxyapatite–pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering. Biomaterials, 2013, 34(12): 2947–2959
Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J. Selforganization mechanism in a bone–like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials, 2001, 22(13): 1705–1711
Tchounwou P B, Yedjou C G, Patlolla A K, Sutton D J. Heavy metal toxicity and the environment. In: Molecular, Clinical and Environmental Toxicology. Berlin: Springer, 2012, 101: 133–164
Ajayan P M, Schadler L S, Braun P V. Nanocomposite Science and Technology. Hoboken: Wiley, 2004, 1–239
Shirdar M R, Taheri M M, Moradifard H, Keyvanfar A, Shafaghat A, Shokuhfar T, Izman S. Hydroxyapatite–titania nanotube composite as a coating layer on Co–Cr–based implants: Mechanical and electrochemical optimization. Ceramics International, 2016, 42(6): 6942–6954
Shirdar MR, Taheri MM, Sudin I, Shafaghat A, Keyvanfar A, Abd Majid M Z. In situ synthesis of hydroxyapatite–grafted titanium nanotube composite. Journal of Experimental Nanoscience, 2016, 11(10): 816–822
Yang S, Leong K F, Du Z, Chua C K. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Engineering, 2001, 7(6): 679–689
Lee K Y, Mooney D J. Hydrogels for tissue engineering. Chemical Reviews, 2001, 101(7): 1869–1879
O’Brien F J. Biomaterials & scaffolds for tissue engineering. Materials Today, 2011, 14(3): 88–95
Zhao C, Tan A, Pastorin G, Ho H K. Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering. Biotechnology Advances, 2013, 31(5): 654–668
Gentile P, Ferreira A M, Callaghan J T, Miller C A, Atkinson J, Freeman C, Hatton P V. Multilayer nanoscale encapsulation of biofunctional peptides to enhance bone tissue regeneration in vivo. Advanced Healthcare Materials, 2017, 6(8): 1601182
Green D, Walsh D, Mann S, Oreffo R O. The potential of biomimesis in bone tissue engineering: Lessons from the design and synthesis of invertebrate skeletons. Bone, 2002, 30(6): 810–815
Stupp S I. Molecular manipulation of microstructures: Biomaterials, ceramics, and semiconductors. Science, 1997, 277(5330): 1242–1248
Stupp S I. Supramolecular materials: Self–organized nanostructures. Science, 1997, 276(5311): 384–389
Beniash E, Hartgerink J D, Storrie H, Stendahl J C, Stupp S I. Selfassembling peptide amphiphile nanofiber matrices for cell entrapment. Acta Biomaterialia, 2005, 1(4): 387–397
Hartgerink J D. Self–assembly and mineralization of peptideamphiphile nanofibers. Science, 2001, 294(5547): 1684–1688
Kikuchi M, Ikoma T, Itoh S, Matsumoto H N, Koyama Y, Takakuda K, Shinomiya K, Tanaka J. Biomimetic synthesis of bone–like nanocomposites using the self–organization mechanism of hydroxyapatite and collagen. Composites Science and Technology, 2004, 64(6): 819–825
Acknowledgements
T. Shokuhfar acknowledges the financial support from NSF-DMR 1710049. M. R. Shirdar and N. Farajpour are thankful to NSFDMR 1564950.
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Shirdar, M.R., Farajpour, N., Shahbazian-Yassar, R. et al. Nanocomposite materials in orthopedic applications. Front. Chem. Sci. Eng. 13, 1–13 (2019). https://doi.org/10.1007/s11705-018-1764-1
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DOI: https://doi.org/10.1007/s11705-018-1764-1