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One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid

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Abstract

Sucrose char sulfonic acid efficiently catalyzed the one-pot three-component Mannich reaction of ketones, aromatic aldehydes and amines in ethanol to afford the corresponding β-amino carbonyl compounds in good to excellent yields. A series of heteroaromatic β-amino carbonyl compounds can be obtained when using 2-acetylpyrazine as substrate. This reaction can be performed under mild reaction conditions with clean reaction profiles and a simple workup procedure.

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Authors and Affiliations

  1. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Institute of Fine Catalysis and Synthesis, Hunan Normal University, Changsha, 410081, China

    Qiong Xu, Zhigao Yang, Dulin Yin & Jihui Wang

Authors
  1. Qiong Xu
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  2. Zhigao Yang
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  3. Dulin Yin
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  4. Jihui Wang
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Correspondence to Dulin Yin.

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Xu, Q., Yang, Z., Yin, D. et al. One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid. Front. Chem. Eng. China 3, 201–205 (2009). https://doi.org/10.1007/s11705-009-0052-5

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  • DOI: https://doi.org/10.1007/s11705-009-0052-5

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