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Mannich reaction in water using acidic ionic liquid as recoverable and reusable catalyst

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The task-specific room-temperature ionic liquid (TSIL) N, N, N-trimethyl-N-butanesulfonic acid ammonium hydrogen sulfate [TMBSA]HSO4 was synthesized as a cheap and recyclable catalyst for one-pot three-component Mannich reaction in water. Sixteen β-amino carbonyl compounds were obtained in good yields under the mild conditions. The products could simply be separated from the catalyst/water, and the catalyst could be reused at least 7 times without noticeably decreasing the catalytic activity.

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Acknowledgments

The financial supports from the Nanjing University of Science & Technology (N0. 2006001) and Yancheng Teachers College are gratefully acknowledged.

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Authors and Affiliations

  1. School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, 210094, P.R. China

    Fang Dong, Luo Jun, Zhou Xin-Li & Liu Zu-Liang

  2. Department of Science & Technology, Yancheng Teachers College, Yancheng, 224002, P.R. China

    Fang Dong

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  1. Fang Dong
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  2. Luo Jun
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  3. Zhou Xin-Li
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  4. Liu Zu-Liang
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Correspondence to Liu Zu-Liang.

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Dong, F., Jun, L., Xin-Li, Z. et al. Mannich reaction in water using acidic ionic liquid as recoverable and reusable catalyst. Catal Lett 116, 76–80 (2007). https://doi.org/10.1007/s10562-007-9095-8

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  • DOI: https://doi.org/10.1007/s10562-007-9095-8

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