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Utilizing Fe (III)-doped carbon quantum dots as a nanoprobe for deferiprone determination in exhaled breath condensate

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Abstract

A fluorescence “turn-off” technique was used for the quantification of deferiprone (DEF) in the exhaled breath condensate. Fe (III)-doped carbon dots (CDs) were synthesized with a hydrothermal method as a fluorescent nanoprobe. The prepared Fe (III)-doped CDs selectively and sensitively detect DEF in the concentration range of 0.05–4.0 μg mL−1 using a fluorescence quenching mechanism and with a limit of detection of 0.012 μg mL−1. As DEF acts as a strong iron chelator, the probe has the potential for DEF analysis in the presence of major interfering chemicals. The significant properties of the prepared probe, such as high stability, low cost, quick analysis, and simple operation, make it a helpful tool in bioanalytical chemistry.

Graphical Abstract

A schematic representation of Fe (III)–doped carbon quantum dots as a nanoprobe for deferiprone analysis

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Acknowledgments

This work was supported by Research Affairs of Tabriz University of Medical Sciences, under grant number 67947.

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Authors and Affiliations

  1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Yasaman Sefid-Sefidehkhan, Mehdi Mokhtari, Abolghasem Jouyban & Elaheh Rahimpour

  2. Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, 1313156199, Iran

    Yasaman Sefid-Sefidehkhan

  3. Faculty of Pharmacy, Near East University, PO BOX: 99138, Nicosia, North Cyprus, Mersin 10, Turkey

    Abolghasem Jouyban

  4. Department of Anesthesiology and Intensive Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Maryam Khoubnasabjafari

  5. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Maryam Khoubnasabjafari

  6. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Vahid Jouyban-Gharamaleki

  7. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Elaheh Rahimpour

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  1. Yasaman Sefid-Sefidehkhan
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Correspondence to Elaheh Rahimpour.

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Sefid-Sefidehkhan, Y., Mokhtari, M., Jouyban, A. et al. Utilizing Fe (III)-doped carbon quantum dots as a nanoprobe for deferiprone determination in exhaled breath condensate. Chem. Pap. 77, 1445–1453 (2023). https://doi.org/10.1007/s11696-022-02563-9

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