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A Silver Nanoprism-Based “Off-On” Sensor for Phenytoin Determination in Exhaled Breath Condensate

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Abstract

The present research proposed the use of silver nanoprism in a fluorescent system for phenytoin determination in exhaled breath condensate samples. The fluorescence emission of luminol was quenched by energy transfer to silver nanoprism and then the phenytoin addition induced silver nanoprism aggregation, inhibited the fluorescence quenching of luminol, and resulted in recovery of the fluorescence intensity proportionally with phenytoin concentration. The experimental parameters were optimized using a one-at-a time method, and the method was partially validated according to FDA guideline. The validated method had a good analytical performance to detect phenytoin in the range of 0.01 to 2.0 µg.mL−1, with a detection limit of 0.005 µg.mL−1.

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Data Availability

All data have been included into the manuscript.

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Funding

This work was supported by Research Affairs of Tabriz University of Medical Sciences, under grant number 71065.

Author information

Authors and Affiliations

  1. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Aynaz Zarghampour & Zahra Karimzadeh

  2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Aynaz Zarghampour, Zahra Karimzadeh, Elaheh Rahimpour & Abolghasem Jouyban

  3. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Maryam Khoubnasabjafari

  4. Department of Anesthesiology and Intensive Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Maryam Khoubnasabjafari

  5. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran

    Vahid Jouyban-Gharamaleki

  6. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Vahid Jouyban-Gharamaleki

  7. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Elaheh Rahimpour

  8. Faculty of Pharmacy, Near East University, PO BOX: 99138, Nicosia, Mersin 10 North Cyprus, Turkey

    Abolghasem Jouyban

Authors
  1. Aynaz Zarghampour
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  2. Zahra Karimzadeh
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  3. Maryam Khoubnasabjafari
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  4. Vahid Jouyban-Gharamaleki
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  5. Elaheh Rahimpour
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  6. Abolghasem Jouyban
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Contributions

AZ: investigation, writing the first draft; ZK: investigation; MK: collecting the real samples; VJ-G: the device managing; ER: data curation, writing—review and editing; AJ: supervision, writing—review and editing. All authors reviewed the manuscript.

Corresponding author

Correspondence to Elaheh Rahimpour.

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Ethics Approval and Consent to Participate

Sample donors signed a consent form approved by the Ethics Committee of the Tabriz University of Medical Sciences (Approval No. IR.TBZMED.VCR.REC.1401.345).

Conflict of Interest

The authors declare no competing interests.

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Zarghampour, A., Karimzadeh, Z., Khoubnasabjafari, M. et al. A Silver Nanoprism-Based “Off-On” Sensor for Phenytoin Determination in Exhaled Breath Condensate. Plasmonics (2023). https://doi.org/10.1007/s11468-023-02157-5

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  • DOI: https://doi.org/10.1007/s11468-023-02157-5

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