Dear Editor,

We read with great interest the article of Sisik et al. in a recent issue of the journal [1]. The authors performed a case-control study on 168 patients who underwent laparoscopic sleeve gastrectomy and concluded that factors such as duration of surgery and first flatus time but not the administration of local bupivacaine have an impact on acute pain. The authors should be congratulated for performing a well-designed study in an important topic (e.g., acute pain) in patients undergoing bariatric surgery [2, 3]. The current emphasis on the need to improve overall postoperative recovery and patient satisfaction makes the topic very important in perioperative medicine [4, 5].

Although the study of Sisik et al. was well conducted, there are some critical points that need to be clarified by the authors to determine the validity of the authors’ findings. First, the authors do not report the total intraoperative opioid consumption by each study group which is important since it can directly affect the primary outcome. Second, the authors performed multiple analyses but it appears they did not adjust their p values to avoid type I errors. Finally, the data collection performed by clinical nurses has been shown to be biased for analgesic studies and this may have contributed for the lack of an observed effect [6].

We would welcome comments by the authors as this would help to further validate the findings of this important clinical study.