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Duodenal Exclusion but Not Sleeve Gastrectomy Preserves Insulin Secretion, Making It the More Effective Metabolic Procedure

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Abstract

Introduction

There is an ongoing debate on which procedure provides the best treatment for type 2 diabetes. Furthermore, the pathomechanisms of diabetes improvement of partly anatomically differing operations is not fully understood.

Methods

A loop duodenojejunostomy (DJOS) with exclusion of one third of intestinal length, a sleeve gastrectomy (SG), or a combination of DJOS + SG was performed in 8-week-old male ZDF rats. One, three, and six months after surgery, an oral glucose tolerance test and measurements of GLP-1, GIP, insulin, and bile acids were conducted.

Results

After an initial (4 weeks) equal glucose control, DJOS and DJOS + SG showed significantly lower glucose levels than SG 3 and 6 months after surgery. There was sharp decline of insulin levels in SG animals over time, whereas insulin levels in DJOS and DJOS + SG were preserved. GIP levels were significantly larger in both groups containing a sleeve at all three time points, whereas GLP-1 was equal in all groups at all time. Bile acid levels were significantly higher in the DJOS compared to the SG group at all time points. Interestingly, the additional SG in the DJOS + SG group led to lower bile acid levels 1 and 6 months postoperatively.

Conclusion

The effect of SG on glucose control was transient, whereas a duodenal exclusion was the more effective procedure in this model due to a sustained pancreatic function with a preserved insulin secretion.

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Acknowledgements

The authors thank Silke Hempel for the outstanding work in assistance with ELISA measurements. Moreover, we thank Claudia Bravo and Monika Kolterjahn for the excellent work with animal care.

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Authors and Affiliations

  1. Department of General and Visceral Surgery, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany

    Claudia Laessle, Gergana Nenova, Goran Marjanovic, Gabriel Seifert, Lampros Kousoulas, Bernd Jaenigen, Stefan Fichtner-Feigl & Jodok Matthias Fink

  2. Department of General and Visceral Surgery, Albert-Ludwigs-University, Hugstetter Straße 55, 79106, Freiburg, Germany

    Claudia Laessle

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  1. Claudia Laessle
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Correspondence to Claudia Laessle.

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Laessle, C., Nenova, G., Marjanovic, G. et al. Duodenal Exclusion but Not Sleeve Gastrectomy Preserves Insulin Secretion, Making It the More Effective Metabolic Procedure. OBES SURG 28, 1408–1416 (2018). https://doi.org/10.1007/s11695-017-3045-3

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