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The Effect of Helicobacter pylori on Postoperative Outcomes in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis

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Abstract

Helicobacter pylori (HP) occurs in 50% of people worldwide with higher rates reported in the bariatric population. HP has been associated with adverse outcomes following bariatric surgery; however, its true impact has not yet been defined. We aimed to systematically review the effect of HP on bariatric surgery outcomes. A comprehensive literature review was conducted yielding seven studies with 255,435 patients. Meta-analysis found comparable rates of bleeding, leak, hospital length of stay, and weight loss between HP-positive and HP-negative patients. HP was, however, found to be the largest independent predictor of marginal ulceration in those undergoing RYGB, with a tenfold increase versus HP-negative patients. Overall, HP is associated with increased marginal ulceration rates, but has little impact on other bariatric surgery outcomes.

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Authors and Affiliations

  1. Department of Surgery, University of Alberta, Edmonton, AB, Canada

    Valentin Mocanu, Jerry T. Dang, Noah Switzer & Daniel Skubleny

  2. Department of Surgery, University of Alberta Hospital, 8440 112 Street NW, Edmonton, AB, T6G 2B7, Canada

    Valentin Mocanu

  3. Centre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, AB, Canada

    Xinzhe Shi, Chris de Gara, Daniel W. Birch & Shahzeer Karmali

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  1. Valentin Mocanu
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  2. Jerry T. Dang
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  3. Noah Switzer
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  4. Daniel Skubleny
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  5. Xinzhe Shi
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Correspondence to Valentin Mocanu.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Conflict of Interest Statement

Authors 1, 2, 3, 4, 5, and 6—none to declare.

Author 7 is a consultant and has received educational grants from Ethicon and Covidien, educational grants from Stryker, and teaching honoraria from Cook Surgery and Bard Davol.

Author 8 is a consultant for Gore Medical and Ethicon.

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Mocanu, V., Dang, J.T., Switzer, N. et al. The Effect of Helicobacter pylori on Postoperative Outcomes in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. OBES SURG 28, 567–573 (2018). https://doi.org/10.1007/s11695-017-3024-8

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