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The Impact of Helicobacter pylori on Laparoscopic Sleeve Gastrectomy Postoperative Complications: a Systematic Review and Meta-analysis

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Abstract

We aimed to assess the impact of Helicobacter pylori infection on postoperative outcomes following laparoscopic sleeve gastrectomy (LSG). We searched Cochrane, Scopus, and PubMed databases, reviewed 1026 studies, and thoroughly analyzed 42 of them. Our final analysis included 13 studies comprising 6199 patients. We found that H. pylori infection was correlated with higher rates of risk of overall postoperative complications (OR 1.56; 95% CI 1.13, 2.16; P = 0.007) and staple line leak (OR 1.89; 95% CI 1.05, 3.41; P = 0.03). There were no significant differences in hospital length of stay or postoperative bleeding rates. Despite observed correlations between H. pylori positivity in gastric specimen and postoperative complications in LSG, definitive causation remains elusive, emphasizing the need for prospective randomized studies evaluating the effect of preoperative H. pylori screening and eradication.

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Authors and Affiliations

  1. Universidade Federal da Fronteira Sul (UFFS), Rua Capitão Araújo, 20, Passo Fundo, RS, 99010121, Brazil

    Patrícia Marcolin, Matheus Machado Berleze & Jossimara Polettini

  2. Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Avenida Professor Mário Rubens Guimarães Montenegro, S/N, Botucatu, SP, 18618687, Brazil

    Maria A. Marchesan Rodrigues & Daniela Augustin Silveira

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Correspondence to Matheus Machado Berleze.

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Key Points

• We found a correlation between H. pylori and postoperative complications after LSG.

• We found a correlation between H. pylori and staple line leak after LSG.

• We highlight the need for prospective trials on H. pylori screening before LSG.

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Marcolin, P., Machado Berleze, M., Polettini, J. et al. The Impact of Helicobacter pylori on Laparoscopic Sleeve Gastrectomy Postoperative Complications: a Systematic Review and Meta-analysis. OBES SURG 33, 3649–3657 (2023). https://doi.org/10.1007/s11695-023-06858-y

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