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Lipid Profile Changes in the Severely Obese after Laparoscopic Sleeve Gastrectomy (LSG), 1, 3, and 5 Years after Surgery

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Abstract

Background

Since there is an increasing acceptance of the laparoscopic sleeve gastrectomy (LSG) and limited information regarding its effect on cardiac risk factors, we assessed lipid profiles.

Methods

A retrospective review of patient records pre and post LSG was performed. Analysis of variance evaluated group differences and paired t tests compared variable changes.

Results

Eighty two patients (67 % female, age 46.4 ± 13.9) had presurgery lipid profiles and follow-up (43 at 1 year, 28 at 3 years, and 26 at 5 years). Groups were not different in gender distribution. The presurgery mean body mass index (BMI) was 55.7 kg/m2; 65.9 % of the subjects were super obese. After surgery, percentage of excess BMI loss was 58.1 % year (yr) 1, 61.3 % yr 3, and 39.0 % yr 5. Lipids were within the normal ranges for all parameters at all times; however, at baseline 77 % had at least one abnormality. At 1 year, triglycerides decreased significantly from baseline (adjusted p value (adj-p) = 0.004) and high-density lipoprotein (HDL) increased (adj-p = 0.025). Year 3 HDL was significantly different from baseline, adj-p = 0.0001. Yr 3 cholesterol increased from baseline, (adj-p = 0.027). Negative linear correlations with weight loss were present for low-density lipoprotein (LDL) at yr 3(r = 0.46, p = 0.02) and triglyceride change at year 5 (r = 0.48, p = 0.02). The percentage of patients with dyslipidemia or medicated did not change significantly during these 5 years.

Conclusions

For this population electing LSG, mean lipid profiles were within normal ranges for all parameters before surgery. However, 77 % showed at least one abnormality presurgery. Weight change correlated with some changes of triglycerides, HDL, and LDL over time, but the impact was limited.

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Acknowledgments

Ms. Ya-lin Chiu was partially supported by the following grant: Clinical Translational Science Center (CTSC) (UL1-RR024996). This project was supported by Weill Cornell Department of Surgery.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Surgery, Weill Cornell Medical College, 525 E 68th St., Box 294, New York, NY, 10065, USA

    Gladys W. Strain, Taha Saif, Faith Ebel, Gregory F. Dakin, Ricardo Costa, Ya-Lin Chiu & Alfons Pomp

  2. Hospital du Sacre Coeur, Montreal, QC, Canada

    Michel Gagner

Authors
  1. Gladys W. Strain
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  2. Taha Saif
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  3. Faith Ebel
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  4. Gregory F. Dakin
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  5. Michel Gagner
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  6. Ricardo Costa
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  7. Ya-Lin Chiu
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  8. Alfons Pomp
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Corresponding author

Correspondence to Gladys W. Strain.

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Strain, G.W., Saif, T., Ebel, F. et al. Lipid Profile Changes in the Severely Obese after Laparoscopic Sleeve Gastrectomy (LSG), 1, 3, and 5 Years after Surgery. OBES SURG 25, 285–289 (2015). https://doi.org/10.1007/s11695-014-1351-6

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  • DOI: https://doi.org/10.1007/s11695-014-1351-6

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