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Changes in Lipid Profiles in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy (LSG)

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Abstract

Background

Laparoscopic sleeve gastrectomy (LSG) has evolved as a primary weight loss surgery. This study provides changes in lipid profiles in obese patients 1 year after LSG.

Methods

A retrospective analysis of patients who underwent LSG from June 2004 to June 2008 provided data on demographics, body mass index (BMI) changes, co-morbidities, and medication changes. We compared lipid profiles, and the relationship between the lipid profiles and pre-operative weight, BMI, and weight loss. Proportion changes for all variables were also assessed. Lipid profiles for those taking lipid-lowering therapy and patients receiving no medication were evaluated.

Results

Data is presented on 45 patients (58% women) ages 18 to 73 years. Co-morbidities included hypertension (19), hyperlipidemia (22), and diabetes (13). One year after LSG, weight decreased from 161.4 ± 34.3 to 112.9 ± 25.6 kg (p < 0.01). BMI decreased from 57.5 ± 9.6 to 39.9 ± 7.1 kg/m2 (p < 0.01). Patients with elevated triglycerides decreased from 17 to 8 (p < 0.01) while patients with elevated cholesterol increased from 13 to 15. High-density lipoprotein cholesterol (HDL) increased from 48.4 to 54.5 mg/dl (p < 0.01) and triglycerides (TG) decreased from 141.7 to 109.3 mg/dl (p < 0.01). TC/HDL and TG/HDL ratios also, decreased significantly (p < 0.01). There were no changes for total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). TG/HDL changes correlated with pre-op weight (r = 0.363, p < 0.05).

Conclusions

One year after LSG, significant weight loss and improvements in HDL and TG levels, TC/HDL and TG/HDL ratios were observed. TC and LDL levels were unchanged.

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References

  1. Sullivan PW, Ghushchyan VH, Ben-Joseph R. The impact of obesity on diabetes, hyperlipidemia and hypertension in the United States. Qual Life Res. 2008;17(8):1063–71.

    Article  PubMed  Google Scholar 

  2. Nguyen NT, Magno CP, Lane KT, et al. Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: findings from the National Health and Nutrition Examination Survey, 1999 to 2004. J Am Coll Surg. 2008;207:928–34.

    Article  PubMed  Google Scholar 

  3. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.

    Article  CAS  PubMed  Google Scholar 

  4. Vila M, Ruíz O, Belmonte M, et al. Changes in lipid profile and insulin resistance in obese patients after Scopinaro biliopancreatic diversion. Obes Surg. 2009;19(3):299–306.

    Article  PubMed  Google Scholar 

  5. Nguyen NT, Varela E, Sabio A, et al. Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass. J Am Coll Surg. 2006;203:24–9.

    Article  PubMed  Google Scholar 

  6. Langer FB, Hoda R, Bohdjalian A, et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15:1024–9.

    Article  CAS  PubMed  Google Scholar 

  7. Peterli R, Wölnerhanssen B, Peters T, et al. Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Ann Surg. 2009;250:234–41.

    Article  PubMed  Google Scholar 

  8. Vidal J, Ibarzabal A, Romero F, et al. Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjects. Obes Surg. 2008;18(9):1077–82.

    Article  CAS  PubMed  Google Scholar 

  9. Moy J, Pomp A, Dakin G, et al. Laparoscopic sleeve gastrectomy for morbid obesity. Am J Surg. 2008;196:e56–9.

    Article  PubMed  Google Scholar 

  10. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diab Care. 2010;33 Suppl 1:S62–9.

    Article  Google Scholar 

  11. Vierhapper H, Nardi A, Grösser P. Prevalence of paradoxically normal serum cholestrol in morbidly obese women. Metabolism. 2000;49(5):607–10.

    Article  CAS  PubMed  Google Scholar 

  12. Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999–2004). Arch Intern Med. 2008;168:1617–24.

    Article  PubMed  Google Scholar 

  13. Hauser H, Dyer JH, Nandy A, et al. Identification of a receptor mediating absorption of dietary cholesterol in the intestine. Biochemistry. 1998;37:17843–50.

    Article  CAS  PubMed  Google Scholar 

  14. Li L, Batt SM, Wannemuehler M, et al. Effect of feeding of a cholesterol-reducing bacterium, Eubacterium coprostanoligenes, to germ-free mice. Lab Anim Sci. 1998;48:253–5.

    CAS  PubMed  Google Scholar 

  15. Bernard A, Akaoka H, Giraudon P, et al. Viruses and the neuroendocrine system: model of murine obesity induced by cerebral infection by canine distemper virus. Ann Biol Clin (Paris). 1999;57:291–9.

    CAS  Google Scholar 

  16. Vierhapper H, Heinze G, Nowotny P, et al. Serum concentrations of dehydroepiandrosterone sulfate and leptin in obese patients with normal serum cholesterol. Metabolism. 2003;52:379–81.

    Article  CAS  PubMed  Google Scholar 

  17. Brehm A, Pfeiler G, Pacini G, et al. Relationship between serum lipoprotein ratios and insulin resistance in obesity. Clin Chem. 2004;50(12):2316–22.

    Article  CAS  PubMed  Google Scholar 

  18. Marceau P, Hould FS, Lebel S, et al. Malabsorptive obesity surgery. Surg Clin North Am. 2001;81:1113–27.

    Article  CAS  PubMed  Google Scholar 

  19. Dixon JB, O’Brien PE. Lipid profile in the severely obese: changes with weight loss after lap-band surgery. Obes Res. 2002;10:903–10.

    Article  PubMed  Google Scholar 

  20. Wolf AM, Beisiegel U. The effect of loss of excess weight on the metabolic risk factors after bariatric surgery in morbidly and super-obese patients. Obes Surg. 2007;17:910–9.

    Article  PubMed  Google Scholar 

  21. Moon HS, Kim WW, Oh JH. Results of laparoscopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patients. Obes Surg. 2005;15:1469–75.

    Article  Google Scholar 

  22. Ou YO, Loi K, Liew V, et al. Staged laparoscopic sleeve gastrectomy followed by Roux-en-Y gastric bypass for morbidly obese patients: a risk reduction strategy. Obes Surg. 2008;18:1575–80.

    Article  Google Scholar 

  23. Weiner RA, Weiner S, Pomhoff I, et al. Laparoscopic sleeve gastrectomy–influence of sleeve size and resected gastric volume. Obes Surg. 2007;17:1297–305.

    Article  PubMed  Google Scholar 

  24. Santoro S, Malzoni CE, Velhote MC, et al. Digestive adaptation with intestinal reserve: a neuroendocrine-based operation for morbid obesity. Obes Surg. 2006;16:1371–9.

    Article  PubMed  Google Scholar 

  25. Bohdjalian A, Langer FB, Shakeri-Leidenmühler S, et al. Sleeve gastrectomy as sole and definitive bariatric procedure: 5-year results for weight loss and ghrelin. Obes Surg. 2010;20:535–40.

    Article  PubMed  Google Scholar 

  26. Wang Y, Liu J. Plasma ghrelin modulation in gastric band operation and sleeve gastrectomy. Obes Surg. 2009;19:357–62.

    Article  PubMed  Google Scholar 

  27. Melissas J, Daskalakis M, Koukouraki S, et al. Sleeve gastrectomy—A “food limiting” operation. Obes Surg. 2008;18:1251–6.

    Article  PubMed  Google Scholar 

  28. Sheehan MT, Jensen MD. Metabolic complications of obesity. Pathophysiologic considerations. Med Clin North Am. 2000;84:363–85.

    Article  CAS  PubMed  Google Scholar 

  29. Busetto L, Sergi G, Enzi G, et al. Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. Obes Res. 2004;12:1256–63.

    Article  PubMed  Google Scholar 

  30. Schauer PR, Burguera B, Ikramuddin S, et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg. 2003;238:467–85.

    PubMed  Google Scholar 

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None of the authors listed have any conflict of interest related to this manuscript.

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Authors and Affiliations

  1. Department of Surgery, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China

    Feng Zhang

  2. Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medical College, Box 294, 525 E 68th St., New York, NY, 10065, USA

    Gladys Witt Strain, Wen Lei, Gregory F. Dakin, Michel Gagner & Alfons Pomp

Authors
  1. Feng Zhang
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  2. Gladys Witt Strain
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  3. Wen Lei
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  4. Gregory F. Dakin
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  5. Michel Gagner
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  6. Alfons Pomp
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Correspondence to Gladys Witt Strain.

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Zhang, F., Strain, G.W., Lei, W. et al. Changes in Lipid Profiles in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy (LSG). OBES SURG 21, 305–309 (2011). https://doi.org/10.1007/s11695-010-0285-x

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