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Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases

  • Research Article
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Systems and Synthetic Biology

Abstract

Cell cycle is the central process that regulates growth and division in all eukaryotes. Based on the environmental condition sensed, the cell lies in a resting phase G0 or proceeds through the cyclic cell division process (G1→S→G2→M). These series of events and phase transitions are governed mainly by the highly conserved Cyclin dependent kinases (Cdks) and its positive and negative regulators. The cell cycle regulation of fission yeast Schizosaccharomyces pombe is modeled in this study. The study exploits a detailed molecular interaction map compiled based on the published model and experimental data. There are accumulating evidences about the prominent regulatory role of specific phosphatases in cell cycle regulations. The current study emphasizes the possible role of multiple phosphatases that governs the cell cycle regulation in fission yeast S. pombe. The ability of the model to reproduce the reported regulatory profile for the wild-type and various mutants was verified though simulations.

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Abbreviations

WT:

Wild type

Cdc:

Cell division cycle

Cdk:

Cyclin dependent kinase

MPF:

M phase promoting factor

preMPF:

Inactive MPF

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Acknowledgments

PA acknowledges P K Vinod and Nikhil Chaudhary, for useful discussions. KVV acknowledges funds from Department of Science and Technology (DST), India.

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  1. Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, 400 076, India

    P. Anbumathi, Sharad Bhartiya & K. V. Venkatesh

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  1. P. Anbumathi
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  2. Sharad Bhartiya
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  3. K. V. Venkatesh
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Correspondence to Sharad Bhartiya or K. V. Venkatesh.

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Anbumathi, P., Bhartiya, S. & Venkatesh, K.V. Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases. Syst Synth Biol 5, 115–129 (2011). https://doi.org/10.1007/s11693-011-9090-7

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  • DOI: https://doi.org/10.1007/s11693-011-9090-7

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