Abstract
Pentagon Copying Test (PCT) is commonly used to assess visuospatial deficits, but the neural substrates underlying pentagon copying are not well understood. The Qualitative Scoring Pentagon Test (QSPT), an optimized scoring system, classifies five categories of errors patients make in pentagons copying and grades them depending on the errors’ severity. To determine the strategic brain regions involved in the PCT, we applied the QSPT system to evaluate the visuospatial impairment of 136 acute ischemic stroke patients on the PCT and used Support Vector Regression Lesion-Symptom Mapping to investigate relevant brain regions. The total QSPT score was correlated with the right supramarginal gyrus. The angle number errors and closure errors were principally associated with lesions of the posterior temporoparietal cortex, including the right middle occipital gyrus and middle temporal gyrus, while the intersection errors and rotation errors were related to the more anterior part of the right temporoparietal lobe with the additional frontal cortex. In conclusion, the right temporoparietal cortex is the strategic region for pentagon copying tasks. The angle number and closure represent the visuospatial processing of within-object features, while intersection and rotation require between-object manipulation. The posterior-anterior distinction in the right temporoparietal region underlies the differences of within-object and between-object processing.
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Acknowledgements
We would like to acknowledge Dr. Lei Zhao for sharing the MATLAB script of SVR-LSM and providing helpful instructions for this project. The authors also thank everyone who contributed to the project.
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This work was supported by National Natural Science Foundation of China (81600929) and the Health Science and Technology Project Fund of Shanghai Pudong New Area Health and Family Planning Commission (PW2018D-02).
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SB and WL designed and organized the study. NZ, JG, WC and GC collected and analyzed the data. YS and LW performed the cognitive assessments. SB drafted the mauscript, and WL and YG revised the manuscript. All authors approved the submitted version.
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Bai, S., Zhi, N., Geng, J. et al. Distinct roles of right temporoparietal cortex in pentagon copying test. Brain Imaging and Behavior 16, 1528–1537 (2022). https://doi.org/10.1007/s11682-021-00607-4
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DOI: https://doi.org/10.1007/s11682-021-00607-4