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Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

The surgical outcome and prognostic factors of intrahepatic cholangiocarcinoma are not fully understood. This study aimed to establish the clinical significance of cirrhosis for prognosis in patients with intrahepatic cholangiocarcinoma after surgery.

Methods

One hundred fifteen patients with intrahepatic cholangiocarcinoma who underwent surgical resection between December 2001 and January 2008 were retrospectively analyzed. The prognostic significance of clinicopathologic factors including cirrhosis was assessed by univariate and multivariate analyses.

Results

Thirty-two of the 115 patients (28%) had liver cirrhosis. Complete tumor removal (R0 resection) was performed in 42 patients (75%). Overall median survival time was 21 months, with 1-, 3-, and 5-year actuarial survival rates of 68%, 27%, and 17%, respectively. There was a significant difference in survival between patients with cirrhosis and those without cirrhosis (P = 0.027). Univariate analysis showed that cirrhosis, vascular invasion, hepatic duct invasion, lymph node metastasis, positive surgical margin (R1), and TNM stage were significantly associated with poor survival. Multivariate analysis showed that cirrhosis, positive surgical margin, and lymph node metastases were related to survival, with hazard ratios of 2.49, 3.53, and 4.16, respectively.

Conclusions

Cirrhosis is an independent factor for poor prognosis in intrahepatic cholangiocarcinoma after surgery.

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Conflict of interest

There is no conflict of interest in the study.

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Authors and Affiliations

  1. Department of General Surgery, Third Xiangya Hospital of Central South University, No.138 of Tongzipo Road, Changsha, 410013, China

    Ya-yong Li, Xiao-rong Li, Bu-ning Tian & Dao-jin Chen

  2. Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, Changsha, 410002, People’s Republic of China

    Hao Li & Pin Lv

  3. National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Xiangya Hospital, Central-south University, Changsha, 410008, People’s Republic of China

    Gang Liu

Authors
  1. Ya-yong Li
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  2. Hao Li
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  4. Gang Liu
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Corresponding author

Correspondence to Dao-jin Chen.

Additional information

Ya-yong Li and Hao Li contributed equally to this study and are co-first authors.

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Li, Yy., Li, H., Lv, P. et al. Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment. J Gastrointest Surg 15, 608–613 (2011). https://doi.org/10.1007/s11605-011-1419-8

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  • DOI: https://doi.org/10.1007/s11605-011-1419-8

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