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Developing a sensor for the simultaneous determination of adrenaline, uric acid, and tryptophan

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Abstract

A chemically modified electrode is constructed based on a coumestan derivative and multiwall carbon nanotubes modified carbon paste electrode (CMWCNT-CPE). The surface charge transfer rate constant, k s, and the charge transfer coefficient, α, for the electron transfer between coumestan and MWCNT-CPE were estimated. CMWCNT-CPE presents a highly catalytic activity for adrenaline (AD) electrooxidation. The results show that the peak potential of AD at the CMWCNT-CPE surface shifted by about 145 mV toward negative values compared with that at the MWCNT-CPE surface. Differential pulse voltammetry exhibited three linear ranges and a detection limit of 0.2 μM for AD. For a mixture containing AD, uric acid (UA), and tryptophan (Trp), three signals corresponding to the analytes could well separate them from each other. Moreover, CMWCNT-CPE was used to determine AD in an adrenaline injection solution and UA in a human urine sample with satisfactory results. To confirm the proposed method, the AD injection solution and the urine sample were spiked with different certain amounts of AD, UA, and Trp.

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Authors and Affiliations

  1. Scientific Society of Nanotechnology, Yazd Branch, Islamic Azad University, Yazd, Iran

    Navid Nasirizadeh & Zahra Shekari

  2. Department of Textile Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran

    Navid Nasirizadeh

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  1. Navid Nasirizadeh
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  2. Zahra Shekari
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Correspondence to Navid Nasirizadeh.

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Nasirizadeh, N., Shekari, Z. Developing a sensor for the simultaneous determination of adrenaline, uric acid, and tryptophan. Ionics 20, 275–285 (2014). https://doi.org/10.1007/s11581-013-0956-4

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  • DOI: https://doi.org/10.1007/s11581-013-0956-4

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