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Journal of Urban Health

, Volume 85, Issue 6, pp 880–909

An Overview of 9/11 Experiences and Respiratory and Mental Health Conditions among World Trade Center Health Registry Enrollees

  • Mark Farfel
  • Laura DiGrande
  • Robert Brackbill
  • Angela Prann
  • James Cone
  • Stephen Friedman
  • Deborah J. Walker
  • Grant Pezeshki
  • Pauline Thomas
  • Sandro Galea
  • David Williamson
  • Thomas R. Frieden
  • Lorna Thorpe
Open Access
Article
First Online:
Received:
Accepted:

Abstract

To date, health effects of exposure to the September 11, 2001 disaster in New York City have been studied in specific groups, but no studies have estimated its impact across the different exposed populations. This report provides an overview of the World Trade Center Health Registry (WTCHR) enrollees, their exposures, and their respiratory and mental health outcomes 2–3 years post-9/11. Results are extrapolated to the estimated universe of people eligible to enroll in the WTCHR to determine magnitude of impact. Building occupants, persons on the street or in transit in lower Manhattan on 9/11, local residents, rescue and recovery workers/volunteers, and area school children and staff were interviewed and enrolled in the WTCHR between September 2003 and November 2004. A total of 71,437 people enrolled in the WTCHR, for 17.4% coverage of the estimated eligible exposed population (nearly 410,000); 30% were recruited from lists, and 70% were self-identified. Many reported being in the dust cloud from the collapsing WTC Towers (51%), witnessing traumatic events (70%), or sustaining an injury (13%). After 9/11, 67% of adult enrollees reported new or worsening respiratory symptoms, 3% reported newly diagnosed asthma, 16% screened positive for probable posttraumatic stress disorder (PTSD), and 8% for serious psychological distress (SPD). Newly diagnosed asthma was most common among rescue and recovery workers who worked on the debris pile (4.1%). PTSD was higher among those who reported Hispanic ethnicity (30%), household income <$25,000 (31%), or being injured (35%). Using previously published estimates of the total number of exposed people per WTCHR eligibility criteria, we estimate between 3,800 and 12,600 adults experienced newly diagnosed asthma and 34,600–70,200 adults experienced PTSD following the attacks, suggesting extensive adverse health impacts beyond the immediate deaths and injuries from the acute event.

Keywords

World Trade Center Asthma Respiratory symptoms Posttraumatic stress disorder Serious psychological distress Population estimates of WTC disaster health outcomes World Trade Center Health Registry (WTCHR) Environmental exposures New York City Children Terrorism WTC attacks Epidemiology Mental health 
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Introduction

The events of September 11, 2001 in New York City were unprecedented. Two airliners crashed into the World Trade Center (WTC) twin towers, resulting in large explosions and fires. The towers collapsed within 2 hours. Four buildings or structures collapsed later, and 32 other buildings sustained moderate to major damage. Nearly 2,800 people died, including more than 2,200 civilians, 343 firefighters, and 60 police officers. Hundreds of thousands of people were exposed to environmental contaminants and witnessed potentially traumatic events. Tens of thousands of lower Manhattan building occupants, residents, and school children were evacuated and had their lives and livelihoods disrupted for months to years afterward. An estimated 91,000 rescue workers, volunteers, construction contractors, and others arrived to work at or nearby the WTC site on 9/11 or in the days and months thereafter, shifting from rescue to recovery.1 The effort involved city, state, and federal agency employees as well as contracted workers and volunteers from all 50 states.

The collapse and burning of the WTC towers and neighboring buildings released a complex mixture of irritant dust, smoke, and gaseous materials. Most dust was an alkaline mixture of pulverized concrete, glass, plastic, paper, and wood fibers. Testing of airborne and settled dust detected the presence of heavy metals, asbestos, and other substances.2 The composition of smoke and dust deposited on indoor and outdoor surfaces varied widely by date and by location.3 In subsequent months, resuspended particulate matter and fires were the main sources of airborne contaminants.

Many studies of surviving first responders and other WTC rescue and recovery workers after 9/11 have documented high levels of respiratory symptoms, severe persistent cough (“WTC cough”), reactive airways disease, asthma, and declines in pulmonary function.4, 5, 6, 7, 8, 9, 10, 11, 12 These reports are consistent with animal studies showing mild to moderate pulmonary inflammation and significant increases in airway hyperresponsiveness in mice exposed to high levels of fine particulate matter from the WTC site.13 Few studies have evaluated respiratory effects among exposed individuals other than rescue and recovery workers.

The trauma of 9/11 triggered depression, anxiety, substance use, and posttraumatic stress disorder.14, 15, 16, 17 Many survivors witnessed the death of friends and co-workers; thousands lost family members in the attacks. In the wake of the disaster, many rescue, recovery, and cleanup workers or volunteers, as well as residents, office workers, and students in lower Manhattan were subjected to daily stress that continued for months.18, 19, 20

The World Trade Center Health Registry (WTCHR) is the largest postdisaster registry in U.S. history. The WTCHR is a key public health resource to document the duration and severity of health impacts, guide decisions about medical care and other services, connect individuals to specific services, and inform response planning for future disasters. This article provides an overview of the WTCHR, the enrollees, their exposures and event experiences, and their respiratory symptoms and mental health status, based on an initial interview 2–3 years after the event.

Methods

The WTCHR was created in July 2002 as a collaborative effort between the Agency for Toxic Substances and Disease Registry (ATSDR) and the New York City Department of Health and Mental Hygiene (NYC DOHMH). Development of eligibility criteria took into account proximity by time and place to the WTC attack, acute exposure to the dust and debris cloud that resulted immediately from the collapse of the towers, and chronic exposure to smoke and fumes in the vicinity of the WTC site. Four broad eligibility groups were constructed: (a) people who were present south of Chambers Street in lower Manhattan on the morning of 9/11, including building occupants, passersby, and people in transit (see map insert, Figure 1); (b) workers and volunteers involved in rescue, recovery, cleanup, and other activities at the WTC site, the Staten Island Recovery Operations Center, or on a transport barge from the WTC site for at least one shift anytime from September 11, 2001 through June 30, 2002; (c) people with a primary residence south of Canal Street in lower Manhattan on 9/11; and (d) students enrolled in and staff employed at schools (grades pre-K to 12) south of Canal Street on 9/11.
FIGURE 1.

Geographic distribution of registrants’ primary residences on September 11, 2001. A natural breaks classification scheme was used for the metropolitan NYC zip codes.

The estimated total number of people eligible for the WTCHR was calculated to be 409,492, the methods for which are published elsewhere.1 Registrants were recruited for enrollment through outreach to eligible individuals and groups, as well as local and regional media. Lists of names and associated contact information of potentially eligible persons were provided voluntarily by entities such as employers and governmental agencies. All persons originally contacted via lists were classified as “list-identified”. A total of 232 lists representing 135,450 potential registrants were provided: rescue, recovery, and cleanup workers and volunteers (144 lists), building occupants (76 lists), students and school staff (nine lists), and residents of lower Manhattan (three lists). A key resource for contacting WTC building survivors was a Port Authority of New York and New Jersey list which contained 95,442 names of people who had received security clearance at WTC buildings 1–7.21 Potentially eligible persons on the lists were recruited by telephone or letter. Individuals were also contacted through a widespread advertising campaign that encouraged them to enroll by using a toll-free number or by preregistering on a WTCHR website; these individuals were contacted and interviewed over the telephone and classified as self-identified.

Data Collection

Of the 71,437 baseline interviews conducted between September 2003 and November 2004 (2–3 years post-9/11), 67,527 (95%) were completed using computer-assisted telephone interviewing (CATI) and the remaining 3,910 were completed using computer-assisted in-person personal interviewing (CAPI). The questionnaire was administered in four languages: English (95.2%), Spanish (1.9%), Cantonese (1.5%), and Mandarin (1.0%). A translation service provided by a vendor was used to interview registrants whose primary language was not one of the pretranslated languages (n = 315). The interviewer took actions (e.g., suggested taking a break, stopped the interview, provided a referral) if a respondent’s answers or behavior indicated emotional distress.

A total of 3,100 proxy interviews were completed. For children under 18 years of age at the time of interview, parents and guardians served as proxies (n = 2,635). Proxy interviews were conducted for adults if the potential registrant was deceased after 9/11 (n = 157), seriously physically or mentally disabled or unable to respond for other reasons (n = 308). For eligible individuals who died after 9/11, a limited number of questions (e.g., demographics, cause of death, and contact information) were completed by proxy.

The WTCHR protocol, including the baseline survey, was approved by the Institutional Review Boards of the Centers for Disease Control and Prevention and the NYC DOHMH in 2003. A Federal Certificate of Confidentiality was obtained.

The baseline survey was designed to take approximately 30 min to administer. The interview included: (a) informed consent; (b) determination of eligibility; (c) demographics; (d) contact information for follow-up (including information on up to three people who would be likely to know the future whereabouts of the respondent); (e) general exposure questions (e.g., to the dust and debris cloud); (f) specific exposure assessment sections for each of the four eligibility groups; (g) 9/11 injuries; (h) physical health symptoms and conditions before and after 9/11; and (i) mental health outcomes.

Health Outcomes

Enrollees were asked about physical health outcomes, including: (a) injuries sustained on 9/11 ranging from eye injury or irritation to fractures, burns and concussions; (b) new or worsening respiratory symptoms at any time after 9/11; (c) new or worsening nonrespiratory symptoms including hearing problems or hearing loss, severe headaches, heartburn, indigestion, or reflux; and skin rash or irritation; and (d) specific conditions diagnosed by a physician or other health professional anytime in the 2–3 years after 9/11, including newly diagnosed asthma, emphysema, hypertension, coronary heart disease, angina, heart attack, diabetes, stroke, and any cancer or malignancy. Questions about symptoms were similar to well-tested examples used in the Behavioral Risk Factor Surveillance System.22 Physical health outcomes presented in this report are restricted to post-9/11 respiratory symptoms and development of newly diagnosed asthma among persons with no history of prior asthma.

Mental health outcomes included probable posttraumatic stress disorder (PTSD) and serious psychological distress (SPD) in the 30 days prior to the interview. The Kessler-6 scale (K-6), used to determine SPD, is a psychometrically validated, epidemiologic screening measure used in the National Health Interview Survey since 1997.23 It is correlated with diagnostic measures of major depressive disorder, generalized anxiety disorder, schizophrenia, and other mental disorders.24 This paper reports the proportion of respondents who scored above a cutoff of 13 on the K-6 scale to indicate current SPD at the time of the baseline interview.

The adult interview also included the PTSD-Checklist Civilian Version (PCL), a 17-item symptom scale corresponding to the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, DSM-IV criteria.25 First validated with samples of U.S. veterans, the PCL has been validated for use with civilian populations such as those exposed to assault, motor vehicle trauma, and life-threatening or terminal illnesses.26, 27, 28, 29, 30, 31 This outcome is referred to as current probable PTSD to acknowledge that self-reported screening instruments do not necessarily indicate psychopathology.32 The overall prevalence of current probable PTSD was calculated using the sum of item responses with a cutoff of 44 which classifies individuals as likely PTSD cases. Proxy interviews with parents and guardians of child enrollees included an eight-question scale derived from Hoven et al. to assess possible posttraumatic stress symptoms.33

Exposure Characterization

The following information from the baseline interview was used to characterize exposures on 9/11 among all enrollees: being caught in the dust and debris cloud that resulted from the collapse of the WTC towers, time and location in the dust cloud, personally witnessing potentially traumatizing events (seeing an airplane hit either one of the WTC towers, a building collapse, people running away, someone who was injured or killed, or people falling or jumping from the WTC towers), and the types of injuries sustained on 9/11. Each eligibility group also had specific questions about exposures that occurred on or after 9/11. Residents, for example, were asked questions about evacuation from their home, including the date of return to their home. Building occupants who evacuated a building on 9/11 were asked about the date of return to their workplace. Rescue/recovery workers and volunteers were asked questions about their work site(s), including dates worked and types of activities. Time periods selected for analysis of post-9/11 exposures were based on characteristics developed by others using meteorological and other environmental data, including dates when rainfall occurred (e.g., September 14 and 19, 2001) and when the fires at the WTC site were extinguished (December 19, 2001).34

GIS Methods

Enrollees were asked about their geographic location when they first encountered the dust cloud. Locator variables included street address (n = 15,167), closest cross street intersection (n = 11,329), closest landmark (n = 10,732), and the closest subway stop (n = 1,119). Geocoding occurred only if an enrollee answered yes to being caught in the dust cloud. The New York City Department of City Planning’s (DCP) Geosupport application was used for automated batch matching of street addresses. DCP’s LION geodatabase (available at: http://www.nyc.gov/html/dcp/html/bytes/dwnlion.shtml) was used for geocoding street intersections and manual, interactive address matching of more complicated or incomplete address data.

A standard deviational ellipse was constructed, centered on the mean center of all the geocodable locations reported by enrollees when they first encountered the dust cloud, with its long axis in the direction of maximum dispersion and its short axis in the direction of minimum dispersion.35,36 The 1 and 2 standard deviational ellipses correspond to 68.2% and 95.4% of the geocoded data, respectively.

Data Analysis

All enrollees were included in the data analysis. To maintain comparability across groups, analyses of respiratory and mental health outcomes, and total burden of illness, were restricted to adult enrollees (>18 years of age) at the time of the interview, including the 157 decedents for whom only limited data were obtained via proxy interviews. This paper does include a brief summary of children’s health outcomes, based on a separate analysis of the proxy interviews with parents and guardians.

SAS® (version 9.1) was used to compute descriptive statistics and bivariate associations between health symptoms or conditions and demographic characteristics, risk factors, and selected event exposures and experiences.37 Chi-square and Cochran–Armitage tests were used to determine statistical significance. Chow and Rodgers’ Euler–Venn applet software was used to create a proportional-to-size Venn diagram to depict overlap in eligibility criteria among enrollees.38

To construct estimates of the total number of adults eligible for the WTCHR who experienced illness or symptoms after the attacks, the prevalence of self-reported health problems among enrollees was applied to estimates of the total number of persons exposed for each enrollee category.1 We first categorized all exposed adults into three broad, mutually exclusive, hierarchical categories: (1) rescue and recovery workers and volunteers, (2) building occupants, passersby, and people in transit, and (3) residents south of Canal Street. For each category, two preliminary estimates were calculated: the percentage of health problems among list-identified and self-identified persons in the WTCHR, and the respective estimated denominators for each of these. For all exposed population categories and all health problems, the prevalence of self-reported disease was higher among self-identified than among list-identified persons. To construct a plausible midpoint estimate of total number of ill adults, we assumed that ill persons were more likely to self-enroll in the WTCHR. The midpoint estimate of persons made ill was therefore calculated as the percentage of those with health problems among list-identified persons multiplied by the total population exposed. To arrive at an upper bound estimate, we assumed that the higher percentage of symptoms among the self-identified persons was representative of the entire population and multiplied that percentage by the total population exposed. To arrive at a lower bound estimate, we assumed that even among list-identified persons, those who experienced symptoms were 50% more likely to enroll in the WTCHR than those who did not experience symptoms. To avoid implying more precision than is appropriate, estimates were rounded to the nearest hundred.

Results

Enrollment and Coverage by Eligibility Group

Estimates of population sizes for each of the eligibility groups and the WTCHR coverage were reported previously.1 Both are displayed in nonmutually exclusive groups in Table 1. The total number of people eligible to enroll in the WTCHR was estimated at 409,492, of whom 71,437 enrolled. Based on these population estimates, WTCHR coverage is 17.4%, ranging from 34% coverage among rescue and recovery workers to 12% among building occupants, passersby, and people in transit in lower Manhattan on the morning of 9/11. Coverage is highest among police (75%), sanitation workers (62%), occupants of undamaged buildings near the WTC site (52%), and occupants of damaged or destroyed buildings (43%).
Table 1

Source of interview and coverage by enrollment group, World Trade Center Health Registry

WTCHR enrollment groupsa

Total

Source of Interview

Estimated population size

Estimated coverage

List-identified

Self-identified

N

%

N

%

N

%

N

%

Total

71,437

100.0

21,239

29.7

50,198

70.3

409,492

17.4

Rescue–recovery workers and volunteers

30,665

42.9

11,387

37.1

19,278

62.9

91,469

33.5

 New York City Police Department (NYPD)

3,757

5.3

70

1.9

3,687

98.1

5,000b

75.1

 New York City Fire Department (FDNY)

3,196

4.5

71

2.2

3,125

97.8

11,000

29.1

 Emergency Medical Service (EMS), medical, or disaster personnel

1,314

1.8

86

6.5

1,228

93.5

N/A

N/A

 Construction or engineering

4,363

6.1

2,512

57.6

1,851

42.4

20,397

21.4

 NYC Department of Sanitation

2,117

3.0

1,786

84.4

331

15.6

3,400

62.3

 Volunteer organizations

5,500

7.7

3,669

66.7

1,831

33.3

26,480

20.8

 Unaffiliated volunteers

1,889

2.6

461

24.4

1,428

75.6

N/A

N/A

 State agencies

336

0.5

81

24.1

255

75.9

8,897

3.8

 Federal Emergency Management Agency (FEMA)

436

0.6

288

66.1

148

33.9

3,499

12.5

 Federal agencies (not including FEMA)

1,577

2.2

399

25.3

1,178

74.7

5,122

30.8

 Other

6,180

8.7

1,964

31.8

4,216

68.2

N/A

N/A

Schools south of Canal Street

2,646

3.7

397

15.0

2,249

85.0

15,197

17.4

 Students (preK-12)

2,075

2.9

289

13.9

1,786

86.1

12,466

16.6

 Staff

571

0.8

108

18.9

463

81.1

2,731

20.9

Residents south of Canal Street

14,665

20.5

3,850

26.3

10,815

73.7

57,511

25.5

 Lived south of Chambers Street on 9/11

8,170

11.4

2,241

27.4

5,929

72.6

21,926

37.3

 Lived between Chambers and Canal Streets on 9/11

6,495c

9.1

1,609

24.8

4,886

75.2

35,585

18.3

Building occupants, passersby, and people in transit south of Chambers Street on 9/11

43,487

60.9

9,859

22.7

33,628

77.3

362,092

12.0

 Occupants of WTC towers or other damaged or destroyed buildings

10,393

14.6

3,367

32.4

7,026

67.6

24,015

43.3

 Occupants of other buildings nearby

19,900

27.9

3,589

18.0

16,307

81.9

38,077

52.3

 Passersby or people in transit

13,194

18.5

2,903

22.0

10,295

78.0

300,000

4.4

N/A Data not available

aWTCHR eligibility groups are not mutually exclusive; approximately 26% of registrants belong to more than one eligibility group.

bThe estimated population of 5,000 NYPD workers is most likely an underestimate.

cIncludes 1,176 residents from zip codes 10002 and 10013 that lived north of Canal Street on 9/11.

The largest group of WTCHR enrollees includes people present in lower Manhattan near the WTC site on the morning of 9/11(n = 43,487), including 10,393 occupants of damaged or destroyed buildings, 19,900 occupants of other nearby buildings, and 13,194 passersby or people in transit. The registry’s 30,665 rescue and recovery workers include police, firefighters, emergency medical services workers, construction or engineering personnel, and sanitation workers (n = 14,747) as well as volunteers affiliated with organizations and unaffiliated volunteers (n = 7,389). The registry also includes 14,665 lower Manhattan residents, 2,075 students (pre-K to 12th) and 571 staff from schools in the vicinity of the WTC site.

Twenty-six percent of enrollees met more than one eligibility criterion. The greatest overlap was among building occupants, passersby, and people in transit who were also either workers (n = 7,695) or residents (n = 6,978) or both (n = 795) (Figure 2). Among children, many students in the registry were also residents who were present downtown on the morning of 9/11 (n = 946) or nonresidents but present downtown on the morning of 9/11 (n = 615).
FIGURE 2.

Overlap of major enrollment groups in the WTC Health Registry. Due to the difficulty of accurately representing more than three groups of greatly divergent size with a proportional circle Venn diagram, the smallest eligibility group, Students and School Staff (n = 2646), was excluded from this figure. Its overlap is described in the text.

Overall, 30% of enrollees were recruited from lists (list-identified), and 70% were self-identified. The percentage of list-identified enrollees ranged from 14% among students to 37% among workers.

Enrollee Characteristics, Risk Factors, Exposures, and Injuries

Figure 1 displays enrollees’ primary residence on 9/11 by zip code for the New York City region and nationally. On 9/11, enrollees resided in all 50 states in the U.S. and 15 other countries. Nonetheless, almost 90% of enrollees were residents of New York State or New Jersey (Table 2). Most enrollees (65%) were residents of New York City on 9/11, including large numbers of Manhattan and Brooklyn residents. Manhattan resident enrollees were concentrated in four zip codes in lower Manhattan due to the nature of the WTCHR enrollment criteria.
Table 2

Demographic characteristics, risk factors, self-reported event exposures and injuries by enrollment group, World Trade Center Health Registrya

Parameter

Totalb

WTCHR enrollment groupsa

Rescue–recovery workers and volunteers

Students in schools south of Canal Street

Staff in schools south of Canal Street

Residents south of Canal Street

Building occupants, passersby, and people in transit south of Chambers Street on 9/11

N

%

N

%

N

%

N

%

N

%

N

%

Total

71,437

100.0

30,665

42.9

2,075

2.9

571

5.0

14,665

20.5

43,487

60.9

Demographics

Gender

Male

42,794

59.9

23,780

77.6

1,016

49.0

155

27.2

6,617

45.1

23,231

53.4

Female

28,641

40.1

6,885

22.5

1,059

51.0

416

72.9

8,046

54.9

20,255

46.6

Age group at interview

<18

2,635

3.7

27

0.1

1,633

78.8

2

0.4

2,204

15.1

1,563

3.6

18–24

2,635

3.7

857

2.8

440

21.2

25

4.5

819

5.6

1,574

3.6

25–44

33,927

47.3

16,375

53.6

0

0

223

39.8

4,930

33.6

20,830

47.9

45–64

28,362

39.6

12,360

40.4

0

0

287

51.2

4,754

32.4

17,341

39.9

65+

3,520

4.9

954

3.1

0

0

24

4.3

1,868

12.7

1,921

4.4

Race/ethnicity

Non-Hispanic White

44,970

63.0

21,883

71.4

875

42.2

244

42.7

8,392

57.2

25,859

59.5

Non-Hispanic Black

8,466

11.9

2,698

8.8

215

10.4

88

15.4

823

5.6

6,335

14.6

Hispanic

9,564

13.4

4,139

13.5

401

19.3

127

22.2

1,924

13.1

6,081

14.0

Asian

5,382

7.5

740

2.4

453

21.8

72

12.6

2,844

19.4

3,282

7.6

Other

3,055

4.3

1,205

3.9

131

6.3

40

7.0

682

4.7

1,930

4.4

Total household income at interview (in thousands)c

<25

6,858

11.3

2,182

7.9

N/A

 

110

22.4

2,871

27.7

3,972

10.8

25 to <50

13,081

21.6

5,538

20.0

167

33.9

1,814

17.5

8,195

22.4

50 to <75

12,791

21.1

6,958

25.1

92

18.7

1,339

12.9

7,072

19.3

75 to <150

20,648

34.1

11,187

40.4

105

21.3

2,366

22.9

12,074

33.0

≥150

7,122

11.8

1,836

6.6

18

3.7

1,963

19.0

5,334

14.6

Residence on 9/11

New York City

46,241

64.7

14,895

48.6

2,043

98.5

493

86.3

14,665

100.0

30,981

71.2

Manhattan

21,370

29.9

3,544

11.6

1,547

74.6

289

50.6

14,665

100.0

13,838

31.8

Bronx

3,312

4.6

1,571

5.1

36

1.7

23

4.0

0

0

2,198

5.1

Brooklyn

9,602

13.4

3,426

11.2

264

12.7

98

17.2

0

0

7,286

16.8

Queens

7,797

10.9

3,816

12.4

175

8.4

68

11.9

0

0

5,114

11.8

Staten Island

4,160

5.8

2,538

8.3

21

1.0

15

2.6

0

0

2,545

5.9

Other New York State

10,670

14.9

7,183

23.4

8

0.4

22

3.9

0

0

5,604

12.9

New Jersey

7,294

10.2

2,628

8.6

12

0.6

39

6.8

0

0

5,361

12.3

Connecticut

481

0.7

244

0.8

0

0

0

0

0

0

268

0.6

Otherd

6,751

9.5

5,715

18.6

12

0.6

17

3.0

0

0

1,273

2.9

Risk factors, event exposures and experiences

Smoking status at interview

Current smoker

10,878

15.8

5,146

17.0

N/A

 

87

15.6

1,889

14.6

6,552

15.7

Former smoker

18,038

26.2

8,160

26.9

137

24.6

3,478

26.9

10,697

25.6

Never smoker

39,953

58.0

17,007

56.1

333

59.8

7,556

58.5

24,608

58.8

Caught in dust and debris cloud that resulted from the collapse of the towers on 9/11

Yes

36,452

51.4

11,355

37.2

1,058

52.3

362

64.2

7,195

49.9

30,535

70.7

No

34,457

48.6

19,170

62.8

967

47.8

202

35.8

7,237

50.2

12,628

29.3

Witnessed a traumatic event on 9/11

Witnessed any event

49,551

69.8

15,131

49.5

1,619

79.9

479

84.3

10,378

71.8

39,671

91.7

Type of event witnessed

Airplane hitting WTC

20,247

28.5

5,639

18.4

560

27.9

219

38.6

4,815

33.3

16,573

38.3

People falling or jumping from WTC

20,343

28.8

4,952

16.2

581

29.6

190

34.0

4,002

28.0

18,586

43.5

Buildings collapsing

33,179

46.7

10,898

35.6

1,067

53.1

335

59.0

7,167

49.6

26,456

61.2

People running away from a cloud or smoke

37,620

52.9

9,679

31.6

1,348

66.2

396

40.0

8,168

56.4

33,076

76.5

People injured or killed

23,547

33.3

8,966

29.4

478

24.2

163

29.0

3,753

26.2

19,731

46.0

Injuries on 9/11

Sustained an injury

9,177

12.9

4,654

15.2

78

3.8

72

12.7

965

6.6

6,887

15.9

Type of injury

Burn

1,208

1.7

604

2.0

9

0.4

12

2.1

141

1.0

907

2.1

Broken bone

579

0.8

233

0.8

3

0.1

8

1.4

85

0.6

489

1.1

Concussion

444

0.6

197

0.6

4

0.2

8

1.4

50

0.3

395

0.9

Cut

4,874

6.9

2,995

9.8

37

1.8

26

4.6

400

2.8

3,534

8.2

Sprain or strain

5,278

7.4

2,381

7.8

44

2.1

45

7.9

588

4.1

4,121

9.6

aWTCHR eligibility groups are not mutually exclusive; approximately 26% of registrants belong to more than one eligibility group.

bTotals do not add up to 71,437 because not all the enrollees answered all the questions. N missing = 2 for gender, 358 for age, 2,568 for smoking status, 528 for dust, 339 to 881 for witnessing events, 205 to 493 for types of injuries. Totals and percentages are based on non-missing responses only.

cHousehold income is displayed only for enrollees 18+ years of age at interview. N 18+ = 68,444 for total, 30,546 for rescue–recovery workers and volunteers, 559 for school staff, 440 for adult students, 12,371 for residents, and 41,666 for building occupants, passersby, and people in transit. N missing=7,994 for household income.

dIncludes enrollees from other states (N = 5350), Canada (N = 76), Puerto Rico (N = 33), and those with no zipcode reported (1,292).

N/A Data not available because the majority of student enrollees were under the age of 18 at the time of interview, and proxy interviews resulted in missing data.

Enrollees were predominantly white non-Hispanic, age 25–64 years, and had reported annual household incomes greater than $50,000. The overall prevalence of current smoking among enrollees (15.8%) was lower than the average prevalence among NYC adults in 2004 (18.3%).39

More than half of all enrollees (51%) reported being caught in the dust and debris cloud that resulted from the collapse of the WTC Towers 1 and 2. Building occupants (71%) and school staff (64%) were most likely to report dust cloud exposure, followed by students (52%), residents (50%), and workers (37%). Enrollee location when first caught in the dust cloud on the morning of 9/11 was successfully geocoded using a combination of available location variables for 24,847 of the 36,452 (68%) registrants who reported being caught in the dust cloud. Most (91%) of the reported locations were in lower Manhattan (Figure 3) and heavily concentrated in the immediate vicinity of the WTC site and eastward. A small proportion of enrollees reported being present in more distant areas of Manhattan as well as in the city’s other four boroughs, where the likelihood of being caught in the dust cloud on the morning of 9/11 was lower.
FIGURE 3.

Enrollees’ self-reported locations when first caught in the dust cloud on 9/11. Location data were successfully geocoded for 24,847 (68%) of the registrants who reported being caught in the dust cloud.

Approximately half of enrollees reported witnessing people fleeing from the dust cloud (53%) or collapsing buildings (47%). Many witnessed people injured or killed (33%), people falling or jumping from a building (29%), or an airplane hitting a building (29%). Building occupants, passersby, and people in transit, school staff and school students were most likely to have reported witnessing any of these five types of traumatic events (92%, 84%, and 80%, respectively). The prevalence of any type of injury sustained on 9/11 ranged from 4% in students to 15% in workers and 16% in building occupants, passersby, and people in transit in lower Manhattan on the morning of 9/11. The most commonly reported injuries were cuts and sprains or strains. Fewer enrollees reported more severe injuries such as burns, broken bones, and concussions.

More than 7,400 adult residents (61%) reported that they evacuated their homes on or after 9/11 (Table 3). Of those who evacuated, 9% returned as early as September 13th, 2001. Most (92%) returned to their homes by the time of the interview. More than 24,000 enrollees reported that they had evacuated their workplace on 9/11, with almost 70% of these evacuees returning to their workplace by the time of the interview. On average, workplace evacuees returned to lower Manhattan sooner than residents.
Table 3

Health outcomes and bivariate associations with demographic characteristics, risk factors, and self-reported event exposures among registrants 18 years of age and older at interview, World Trade Center Health Registry (N = 68,444)

Parameter

Totala

Respiratory health measures

Mental health measures

Any new or worsening respiratory symptomsb

Newly diagnosed asthma

Serious psychological distress (SPD)c

Probable PTSDd

N

%

N

%

p value

N

%

p value

N

%

p value

N

%

p value

Total adults

68,444

100.0

45,889

67.1

 

1,967

2.9

 

5,604

8.4

 

10,693

16.3

 

Source of interview

List-identified

20,780

30.4

11,139

53.6

0.0001

335

1.6

0.0001

1,434

7.2

0.0001

2,502

12.7

0.0001

Self-identified

47,664

69.6

34,750

72.9

 

1,632

3.5

 

4,170

9.0

 

8,191

17.8

 

Demographics

Gender

Male

41,343

60.4

27,194

65.8

0.0001

1,013

2.5

0.0001

2,753

6.8

0.0001

5,430

13.6

0.0001

Female

27,099

39.6

18,694

69.0

 

954

3.6

 

2,850

10.8

 

5,262

20.4

 

Age group at interview

18–24

2,635

3.9

1,419

53.9

0.0001

72

2.8

0.586

175

6.8

0.0001

282

10.9

0.0001

25–44

33,927

49.6

22,570

66.5

 

999

3.0

 

2,485

7.5

 

5,036

15.3

 

45–64

28,362

41.4

19,662

69.3

 

808

2.9

 

2,670

9.7

 

4,993

18.4

 

65+

3,520

5.1

2,238

63.6

 

88

2.6

 

274

8.5

 

382

12.5

 

Race/ethnicity

Non Hispanic White

43,560

63.6

27,606

63.4

0.0001

1,192

2.8

0.0001

2,504

5.8

0.0001

4,946

11.6

0.0001

Non-Hispanic Black

8,214

12.0

6,261

76.2

 

206

2.5

 

943

11.9

 

1,962

24.8

 

Hispanic

9,026

13.2

6,912

76.6

 

332

3.7

 

1,473

16.9

 

2,628

30.1

 

Asian

4,828

7.1

3,083

63.9

 

156

3.3

 

376

8.3

 

647

14.6

 

Other

2,816

4.1

2,027

72.0

 

81

3.0

 

308

12.5

 

510

23.6

 

Total household income at interview (in thousands)

<25

6,858

11.3

4,897

71.4

0.0001

246

3.6

0.0018j

1,420

21.6

0.0001

2,017

31.4

0.0001

25 to <50

13,081

21.6

9,296

71.1

 

359

2.8

 

1,624

12.8

 

2,958

23.3

 

50 to <75

12,791

21.1

8,978

70.2

 

389

3.1

 

919

7.3

 

2,001

16.0

 

75 to <150

20,648

34.1

13,950

67.6

 

630

3.1

 

940

4.6

 

2,287

11.3

 

≥150

7,122

11.8

3,945

55.4

 

152

2.1

 

204

2.9

 

579

8.3

 

Risk factors, event exposures, and experiences

All adult enrollees

Smoking status at interview

Current smoker

10,832

16.1

8,010

74.0

0.0001

279

2.6

0.090

1,515

14.3

0.0001

2,515

23.9

0.0001

Former smoker

17,961

26.6

12,244

68.2

 

525

2.9

 

1,181

6.7

 

2,503

14.4

 

Never smoker

38,699

57.3

25,153

65.0

 

1150

3.0

 

2,843

7.5

 

5,621

15.0

 

Caught in the dust and debris cloud that resulted from the collapse of the towers on 9/11

Yes

35,109

51.6

26,640

75.9

0.0001

1,161

3.3

0.0001

3,700

10.8

0.0001

7,243

21.5

0.0001

No

32,886

48.4

19,062

58.0

 

796

2.4

 

1,885

5.9

 

3,415

10.8

 

Witnessed a traumatic event on 9/11

Yes

47,767

70.1

34,172

71.5

0.0001

1,493

3.1

0.0001

4,600

9.9

0.0001

8,950

19.5

0.0001

No

20,378

29.9

11,633

57.1

 

465

2.3

 

990

5.0

 

1,721

8.7

 

Sustained an injury on 9/11

Yes

9,079

13.3

7,802

85.9

0.0001

384

4.3

0.0001

1,637

18.6

0.0001

3,037

35.0

0.0001

No

59,211

86.7

38,086

64.3

 

1,583

2.7

 

3,967

6.9

 

7,656

13.4

 

Rescue–recovery workers and volunteers

Totale

30,546

44.6

21,033

68.9

 

971

3.2

 

2,134

7.2

 

4,206

14.2

 

Location of rescue/recovery workf

Worked at WTC on pile

12,494

40.9

9,966

79.8

0.0001

510

4.1

0.0001

815

6.7

0.0041

1,805

14.8

0.0001

Worked at WTC in another area

17,115

56.0

10,583

61.8

 

437

2.6

 

1,264

7.6

 

2,329

14.1

 

Worked at Staten Island recovery operations

828

2.7

412

49.8

 

20

2.4

 

43

5.3

 

57

7.0

 

Worked on a transport barge

80

0.3

51

63.8

 

2

2.5

 

5

6.5

 

8

10.1

 

Worked on pile on September 11, 2001

Yes

4,096

13.4

3,604

88.0

0.0001

255

6.3

0.0001

241

6.0

0.003

667

16.7

0.0001

No

26,443

86.6

17,422

65.9

 

715

2.7

 

1,892

7.3

 

3,538

13.8

 

Residents

Totale,g

12,371

18.1

8,153

65.9

 

373

3.1

 

1,132

9.6

 

1,775

15.5

 

Evacuated home

Yes, returned by interview

6,836

55.8

4,478

65.5

0.0026

184

2.7

0.0065

575

8.6

0.0004

987

15.1

0.0005

Yes, did not return by interview

622

5.1

392

63.0

 

14

2.3

 

67

10.9

 

126

21.1

 

Did not evacuate home

4,804

39.2

3,272

68.1

 

174

3.7

 

488

10.8

 

660

15.2

 

Period when residential evacuees returned homeh

September 11–13, 2001

594

8.8

431

72.6

0.0001

21

3.6

0.0184j

80

13.9

0.0001

133

23.9

0.0001

September 14–19, 2001

1,534

22.7

1,016

66.2

 

48

3.2

 

127

8.5

 

188

12.8

 

September 20–October 19, 2001

3,058

45.3

1,910

62.5

 

80

2.6

 

211

7.1

 

391

13.3

 

October 20–November 19, 2001

801

11.8

520

64.9

 

17

2.1

 

59

7.6

 

101

13.3

 

November 20–December 19, 2001

349

5.2

233

66.8

 

6

1.7

 

37

10.8

 

54

16.2

 

After December 19, 2001

416

6.2

300

72.1

 

8

1.9

 

48

11.9

 

96

23.8

 

Building occupants, passersby, and people in transit south of Chambers Street on 9/11

Totale

41,666

60.9

28,847

69.2

 

1,247

3.0

 

3,998

9.9

 

7,752

19.4

 

Location on 9/11

Occupant of damaged or destroyed building

10,276

25.0

6,256

60.9

0.0001

255

2.5

0.0001

1,072

10.7

0.0001

2,134

21.4

0.0001

Occupant of undamaged building

18,993

46.1

13,517

71.2

 

555

2.9

 

1,653

8.9

 

3,164

17.3

 

On the street or in transit

11,917

28.9

8,713

73.1

 

425

3.6

 

1,210

10.6

 

2,348

20.8

 

Evacuated workplace

Yes, returned by interview

16,909

57.6

12,205

72.2

0.0001

456

2.7

0.0001

1,369

8.3

0.0001

2,898

17.7

0.0001

Yes, did not return by interview

7,332

25.0

3,999

54.5

 

131

1.8

 

888

12.4

 

1,625

23.1

 

Did not evacuate workplace

5,096

17.4

3,642

71.5

 

158

3.1

 

570

11.6

 

1,043

21.4

 

Period when evacuated workers returned to worki

September 11–13, 2001

2,963

14.4

2,333

78.7

0.0001

104

3.5

0.0632j

287

10.0

0.0503

596

20.8

0.0001

September 14–19, 2001

8,726

42.3

6,323

72.5

 

240

2.8

 

713

8.4

 

1,485

17.5

 

September 20–October 19, 2001

7,053

34.2

5,094

72.2

 

190

2.7

 

612

8.9

 

1,213

17.8

 

October 20–November 19, 2001

1,194

5.8

834

69.9

 

38

3.2

 

88

7.5

 

212

18.4

 

November 20–December 19, 2001

488

2.4

295

60.5

 

9

1.9

 

35

7.3

 

61

12.9

 

After December 19, 2001

231

1.1

158

68.4

 

5

2.2

 

20

9.0

 

44

19.7

 

aTotals do not add up to 68,444 because not all the enrollees answered all the questions. Among all adults, N missing = 2 for gender, 7,944 for income, 952 for smoking status, 449 for dust, 229 for traumatic events and 150 for injury. Totals and percentages are based on non-missing values only.

bIncludes persistent cough, shortness of breath, wheezing, throat irritation, or sinus irritation

cMeasured by Kessler-6. All six questions must have been answered.

dMeasured by PTSD Checklist. All 17 items must have been answered.

eIncludes school staff and adult students only if they are eligible in one of the other three eligibility categories (workers, residents, building occupants). A total of 80 school staff and 58 adult students are excluded

fIf enrollee worked at both WTC and Staten Island/Barge sites, working at the WTC site took precedence for categorization.

gIncludes 953 adult residents from zip codes 10002 and 10013 that lived north of Canal Street on 9/11

hAsked only of residents south of Canal Street who reported that they evacuated. Categories of dates based on when rainfall occurred (September 14th and 19th), and when the fires at the WTC site were extinguished (December 19th).

iAsked only of registrants who worked in a building south of Chambers Street and evacuated. Categories of dates based on when rainfall occurred (September 14th and 19th), and when the fires at the WTC site were extinguished (December 19th).

jBased on Cochran–Armitage test for trend in proportions

Respiratory and Mental Health Outcomes

Overall, 67% of adult enrollees reported any new or worsening respiratory symptom (persistent cough, shortness of breath, wheezing, throat irritation, or sinus irritation) after 9/11 (Table 3). The prevalence of new symptoms ranged from 32% for sinus irritation to 38% for shortness of breath; worsening symptoms were less frequently reported, ranging from 1.6% for persistent cough to 14% for sinus irritation (data not shown). Nearly 3% (n = 1,967) of adult enrollees reported newly diagnosed asthma after 9/11. Overall, 16% of adult enrollees screened positive for current PTSD and 8% for serious psychological distress (SPD).

Demographic variables, smoking status, and source of interview were generally significantly associated with each of the respiratory and mental health outcomes (Table 3). Adult enrollees who were female, non-White, self-identified, or had lower incomes tended to have higher prevalence of a new or worsening respiratory symptom, newly diagnosed asthma, probable PTSD, and SPD.

Event experiences on 9/11 such as being in the dust cloud, witnessing a traumatic event, and sustaining an injury were also significantly associated with a higher likelihood of having either respiratory or mental health adverse outcomes. Each event experience was associated with an approximately twofold or greater increase in the prevalence of psychological distress and probable PTSD. Most strikingly, enrollees who sustained injuries were nearly three times more likely to develop probable PTSD than those who did not (35% vs. 13%).

Associations were also noted between 9/11 experiences and respiratory outcomes (Table 3). Of all enrollees, rescue and recovery workers and volunteers had the highest percentage of reported newly diagnosed asthma and the second highest percentage of respiratory symptoms. Location of rescue and recovery work, in particular, working on the WTC pile itself, was an important predictor of respiratory health outcomes, as was working on the pile on 9/11. Enrollees who worked on the WTC pile on 9/11 were more than twice as likely to have reported newly diagnosed asthma after 9/11 as those who did not (6.3% vs. 2.7%). Location of work was also associated with adverse mental health outcomes (Table 3).

Among eligibility groups, the prevalence of probable PTSD was highest among building occupants, passersby, and people in transit in lower Manhattan on the morning of 9/11 (19%), followed by residents (16%). Evacuation status and time returning home or to work were associated with both adverse respiratory and mental health outcomes. Residents and building occupants who did not evacuate their home or workplace were more likely than those who evacuated to report newly diagnosed asthma. Among evacuees, asthma was also more commonly reported by residents who returned home within the first week (by September 19th) than those who returned later (3.3% vs 2.4%, p = 0.046). Evacuees who had not returned to live or work in lower Manhattan had the highest prevalence of probable current PTSD, significantly higher than enrollees who had not evacuated their home or workplace and those who had returned to their home or workplace by the time of the interview.

Estimated Burden of Health Problems among Adults

Estimates of the total number of adults with symptoms or newly diagnosed illness after the attacks are shown in Table 4. Using data from the WTCHR, we estimate that among the previously estimated eligible population of 409,492 persons, between 124,800 and 232,200 exposed people experienced new or worsening respiratory symptoms after 9/11, 3,800–12,600 had newly diagnosed asthma by 2 to 3 years after the event, 34,600–70,200 developed probable PTSD, and 9,700–20,000 people experienced SPD.
Table 4

Estimates of total burden of illness among registrants 18 years of age and older, based on prevalence of reported health problems in the WTCHR and estimates of populations eligible for WTCHR enrollmenta

Parameter

Lower boundb

Midpointc

Upper boundd

Any new or worsening respiratory symptom

Rescue–recovery workers and volunteers

32,300

41,200

61,800

Building occupants, passersby, and people in transit

86,600

112,400

161,500

Residents south of Canal St.

5,900

7,600

8,900

Total

124,800

161,200

232,200

Newly diagnosed asthma

Rescue–recovery workers and volunteers

1,100

1,600

3,700

Building occupants, passersby, and people in transit

2,400

3,700

8,300

Residents south of Canal St.

300

400

600

Total

3,800

5,700

12,600

Serious psychological distress

Rescue–recovery workers and volunteers

1,700

2,500

3,400

Building occupants, passersby, and people in transit

7,700

11,400

16,000

Residents south of Canal St.

300

400

600

Total

9,700

14,300

20,000

Probable PTSD

Rescue–recovery workers and volunteers

7,300

10,600

13,700

Building occupants, passersby and people in transit

26,500

38,000

54,700

Residents south of Canal St.

800

1,100

1,800

Total

34,600

49,700

70,200

aBurden estimates are rounded to the nearest hundred.

bLower bound estimate adjusts for the possibility that even among listed persons, those ill were 50% more likely to enroll in the WTCHR. The lower bound estimate is the product of the total population exposed and the ratio of A to B, where (A) is the number of list-identified persons who were ill and (B) is the sum of the number of list-identified persons who were healthy ×1.5 and the number of list-identified persons who were ill.

cMidpoint estimate is the product of the percent ill among list-identified persons and the total population exposed

dUpper bound estimate is the product of the percent ill among self-identified persons and the total population exposed

Children’s Respiratory and Mental Health Outcomes

Of the 3,184 enrollees under age 18 years on 9/11, most (69%) were residents of lower Manhattan. Nearly half (45%) of these children were caught in the dust cloud on 9/11, half (50%) had personally witnessed disturbing events, and 53% had at least one new or worsening respiratory symptom after 9/11. Eye irritation or eye injury was reported for 22% of children; other injuries on 9/11 were reported for 3% (including sprains, lacerations, burns, broken bones, or concussions). For 180 children (5.7%), asthma was newly diagnosed after 9/11. Three percent of children met criteria for possible posttraumatic stress at interview. Dust cloud exposure was associated with newly diagnosed asthma.40 Posttraumatic stress symptoms were associated with dust cloud exposure and with witnessing disturbing events.

Discussion

The attacks of 9/11 had adverse health impacts far beyond the immediate deaths and injuries from the acute event. The WTC Health Registry, the largest postdisaster registry in U.S. history, is the best opportunity to measure the magnitude of these health problems. Our study estimates that more than 100,000 adults experienced new or worsening respiratory symptoms after 9/11 and that tens of thousands of cases of probable PTSD and thousands of cases of newly diagnosed asthma developed in the first 2 to 3 years after the event. Our findings raise awareness that these adverse health impacts extended beyond workers involved in rescue and recovery to encompass building occupants, residents, passersby, and people in transit in lower Manhattan on 9/11. These findings also underscore the value of the WTCHR as a resource to inform health care services, project needs for affected populations, and link affected individuals to services.

Systematic measurement of 9/11 exposures identified that registry enrollees were heavily exposed to physical and psychological risks, including being caught in the dust cloud, witnessing traumatic events, and sustaining injuries. These exposures correlated strongly with health symptoms. National estimates of expected adult asthma incidence are limited and vary in their range (3-year rates range from 0.8% to 1.6%); all are two to four times lower than the reported asthma incidence among enrollees 2–3 years after 9/11.41, 42, 43 Symptoms compatible with PTSD were approximately four times higher than national estimates of current PTSD from disparate trauma sources (16% vs. 4%).44 Among enrollees identified through lists, groups which may have been less subject to self-selection bias, PTSD (12.7%) levels were substantially higher than expected background rates. New diagnosis of asthma in the list-identified group (1.6%) was comparable to the higher end of the national estimate spectrum, but was significantly associated with reported disaster exposures (being caught in the dust cloud, sustaining an injury on 9/11).

To date, the WTCHR has a number of in-depth studies published that examine the health impacts on specific populations (Table 5). These studies give additional details on respiratory and mental health findings, as well as more detailed analyses of risk factors and the dose-response association between exposures and health outcomes.12,15,16,21,40 We found that self-reported new diagnosis of asthma was highest among rescue and recovery workers, particularly those working directly on the WTC pile. A previously published WTCHR study of asthma-free workers and volunteers who worked on the WTC site examined the impact of work-related exposures on new diagnosis of asthma and found early arrival time, duration of work on the WTC site, working directly on the pile, and being caught in the initial dust cloud to be independent predictors of developing the condition.12 Other focused studies of rescue and recovery workers have also identified that persons with more intense or prolonged exposure to the WTC collapse and immediate disaster site had more severe respiratory symptoms, conditions, or lung function decline.8, 9, 10, 11,45
Table 5

Summary of previous analysis of health problems using WTCHR

Reference

Population

Sample Size

Health problem

Findings

Associated Factors

Brackbill et al. 200421

Survivors from WTC towers and other damaged buildings

8,418

Various

Injuries—43.6%

Dust cloud exposure

New or worsening respiratory problem—56.6%

New diagnosis of asthma—2.0%

Heartburn/reflux—23.9%

Severe headaches 21.0%

Serious psychological distress—10.7%

Wheeler et al. 200712

Rescue and recovery workers

25,748

Respiratory

New diagnosis of asthma—3.6%.

Longer duration of exposure

Earlier arrival time

Worked on the WTC pile

Delay in using masks or respirators

Perrin et al. 200716

Rescue and recovery workers and volunteers

28,692

Mental health

PTSDa—14.7%. overall

Longer duration of exposure

By selected groups:

Earlier arrival time

Police—7.2%

Performing tasks uncommon for one’s occupation

Volunteer organizations—8.4%

Sanitation—13.0%

Firefighters—14.3%

Construction/engineering—20.8%

Unaffiliated volunteers—24.7%

DiGrande et al. 200815

Residents of lower Manhattan

11,037

Mental health

PTSDa—15.1%.

Women

Minorities

Lower income

Injured on 9/11

Dust cloud exposure

Witnessing traumatic events

Thomas et al. 200840

Children in lower Manhattan

3,184

Respiratory

New diagnosis of asthma—5.7%

Dust cloud exposure

All analyses are based on initial surveys conducted in 2003–2004

aProbable posttraumatic stress disorder based on a score of 44 or greater on the PTSD Checklist Civilian Version (PCL).

Among lower Manhattan adult residents and office workers, asthma and new or worsening respiratory symptoms were more commonly reported among those who did not evacuate at all and those who returned early, in the first week after the attacks, compared to those who returned later. Few studies have examined exposures and health outcomes in lower Manhattan residents or office workers, but elevated respiratory symptoms have been reported elsewhere.46, 47, 48, 49

Few postdisaster studies have addressed new diagnosis of asthma, and no previous disaster is directly comparable to the collapse of the WTC towers on 9/11. Asthma exacerbations have been reported in association with natural disasters, including wild land fires, earthquakes, hurricanes, and volcanic eruptions and wartime exposures to oil fire smoke.50, 51, 52, 53, 54 In the occupational setting, some multicase outbreaks have been described, including irritant-induced asthma among police responding to a roadside spill of chemicals used for polymerized plastic coatings, hospital staff following a spill of acetic acid, and those living or working near a spill of metam sodium pesticide.55, 56, 57

The prevalence estimates of current, probable PTSD among enrollees 2–3 years after the attacks were higher than those based on self-report from random digit dialed studies in New York City among Manhattan residents conducted 6 to 8 weeks after 9/11 (7.5%), among all New York City adults conducted at 4 and 6 months post-9/11 (2.3 and 1.5%, respectively), as well as national estimates for the general population after 9/11 (4%).20,58, 59, 60, 61 Studies done within the first year of other man-made disasters have reported PTSD prevalence in the range of 1% to 11% among the general population and 25–75% among survivors, including a prevalence of 34% among survivors of the Oklahoma City bombing.62, 63, 64, 65, 66, 67, 68, 69 In our study, the PTSD prevalence in each WTCHR eligibility group at 2–3 years post-9/11 falls between these ranges reported for the general population and survivors of other disasters. This is likely due, in part, to the fact that lower Manhattan residents, building occupants, passersby, and people in transit as well as rescue and recovery workers experienced both direct and indirect exposures to 9/11. A WTCHR study of rescue and recovery workers found that those at highest risk of PTSD were in occupations least likely to have had prior disaster training or experience, including unaffiliated volunteers (24.7%) and construction or engineering workers (20.8%). Other risk factors included duration of work, earlier arrival, and performing activities uncommon for one’s occupation (Table 5).16

Consistent with theories about the causes of PTSD, the prevalence of probable PTSD was higher among enrollees who reported direct exposures on 9/11 indicative of life threat such as sustaining an injury (35%), being caught in the dust cloud (22%), or witnessing a traumatic event (20%). Our findings are consistent with known demographic risk factors for PTSD, including female gender, minority racial/ethnic status, low-income, and middle age in adults.58,61,68,70, 71, 72, 73, 74, 75, 76 The relationship between income and PTSD was particularly strong, with persons reporting a household income less than $25,000 having PTSD levels nearly four times as high as those reporting a household income of $150,000 or greater. The other mental health outcome we measured among enrollees was SPD. While less specific in nature, SPD measures psychological distress that is quite severe, usually affecting one’s functionality.24 The prevalence of probable SPD measured among registry enrollees 2–3 years after 9/11 was significantly higher than the citywide prevalence among New York City adult residents during a similar time period (8% compared to 5% in 2003).77

This study has important limitations. The first pertains to the issue of selection bias. Although extensive efforts were made to have a high level of participation in the registry and more than 70,000 persons chose to enroll, the percentage of the estimated eligible persons who enrolled in the registry was low (17.4%), and most enrollees were self-identified. While there were no direct medical, legal, or financial benefits to enrolling in the registry, it is reasonable nonetheless to assume that persons experiencing symptoms were more likely to make the effort to enroll in the registry than those who remained symptom-free. The prevalence of health problems may thus have been overestimated, particularly among the self-identified enrollees. A related potential source of bias is differential enrollment of residents by evacuation status. However, eligible individuals who evacuated after 9/11 would also have been included in the recruitment list building effort, traced intensively in the locating effort by the survey vendor, and exposed potentially to the intensive media and outreach campaigns (e.g., bus, subway, ferry, newspaper, and radio ads).

While the registry is not fully representative, information is available on the population from which the enrolled participants came. Unlike case series studies, the degree of representativeness of registry findings can thus be estimated, and inferences can be made about disease rates; representativeness can be further improved by considering persons recruited from lists, who are less subject to self-selection bias.

A second major limitation pertains to the possibility of recall bias. The registry collected data 2–3 years after the event and relied on self-reported exposure and health information. Enrollees with greater exposure to the disaster may have been more likely to recall symptoms and connect symptoms to the disaster than enrollees with lesser exposure. A related limitation is that timing and severity of symptoms was not collected, and we were unable to distinguish symptoms that resolved immediately or by the time of interview from persistent ones. On the other hand, despite the lack of objective exposure information, we collected detailed information about occupation, location at the time of the event, and duration at high-impact locations that enable the development of proxy measures of exposure to dust or other risks that are less subject to recall bias.

In spite of these limitations, the WTCHR and this study provide a unique perspective on the health effects of the 9/11 disaster. By collecting systematic health information on a wide and diverse group of persons exposed to health risks, it offers among the best estimates of how many people were heavily exposed and the magnitude of adverse health effects. The resultant picture that emerges confirms that the World Trade Center disaster had substantial health implications for large numbers of people, including residents and building occupants who comprise understudied populations post-9/11. Registry data were used to inform the development of physician guidelines and the expansion of 9/11-related services for residents through city-funded programs, including a mental health benefits program and an Environmental Health Center of Excellence described in detail elsewhere (www.nyc.gov/9-11healthinfo).

This paper is the first to provide an overview of selected physical and mental health effects on affected adults within the first 2–3 years of the 9/11 attacks and aftermath. More focused studies are needed to fully investigate the relationship between exposures and health problems, and to characterize the severity and duration of the health effects. The World Trade Center Health Registry continues to track enrollees through periodic health surveys, in-depth studies and periodic matches to vital records, cancer registries, and other health data. It will continue to serve as a key resource to study the duration, scope, and severity of health impacts, identify subgroups for more in-depth studies, guide decisions about medical care and other services, and connect individual people to the specific services they need.

Notes

Acknowledgment

This research was supported by Cooperative Agreement Number U50/ATU272750 from the Agency for Toxic Substances and Disease Registry with additional funding from the CDC’s National Center for Environmental Health. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the ATSDR. The manuscript underwent ATSDR external peer review.

Open Access

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Copyright information

© The Author(s) 2008

Authors and Affiliations

  • Mark Farfel
    • 1
  • Laura DiGrande
    • 1
  • Robert Brackbill
    • 2
  • Angela Prann
    • 1
  • James Cone
    • 1
  • Stephen Friedman
    • 1
  • Deborah J. Walker
    • 1
  • Grant Pezeshki
    • 1
  • Pauline Thomas
    • 3
  • Sandro Galea
    • 4
  • David Williamson
    • 2
  • Thomas R. Frieden
    • 1
  • Lorna Thorpe
    • 1
  1. 1.New York City Department of Health and Mental HygieneNew YorkUSA
  2. 2.Agency for Toxic Substances and Disease RegistryAtlantaUSA
  3. 3.New Jersey Medical School - UMDNJNewarkUSA
  4. 4.School of Public HealthUniversity of MichiganAnn ArborUSA

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