Abstract
Background
Erythropoiesis is regulated by a range of intrinsic and extrinsic factors, including different cytokines. Recently, the role of catecholamines has been highlighted in the development of erythroid cell lineages.
Objective
This study focuses on the biological links interconnecting erythroid development and the sympathetic nervous system. The emerging evidence that underscores the role of catecholamines in the regulation of erythropoietin and other erythropoiesis cytokines are thoroughly reviewed, in addition to elements such as iron and the leptin hormone that are involved in erythropoiesis.
Methods
Relevant English-language studies were identified and retrieved from the PubMed search engine (1981–2017) using the following keywords: “Erythropoiesis”, “Catecholamines”, “Nervous system”, and “Cytokines.”
Results
Chronic social stress alters and suppresses erythroid development. However, the physiological release of catecholamines is an additional stimulator of erythropoiesis in the setting of anemia. Therefore, the severity and timing of catecholamine secretion might distinctly regulate erythroid homeostasis.
Conclusion
Understanding the relationship of catecholamines with different elements of the erythroid islands will be essential to find the tightly regulated production of red blood cells (RBCs) in both chronic and physiological catecholamine activation.
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References
An X, Mohandas N (2011). Erythroblastic islands, terminal erythroid differentiation and reticulocyte maturation. Int J Hematol, 93(2): 139–143
Antonijevic N, Nesovic M, Trbojevic B, Milosevic R (1999). Anemia in hypothyroidism. Med Pregl, 52(3–5): 136–140
Arranz L, Méndez-Ferrer S (2013). Network anatomy and in vivo physiology of mesenchymal stem and stromal cells. Inflamm Regen, 33:038-04
Artico M, Bosco S, Cavallotti C, Agostinelli E, Giuliani-Piccari G, Sciorio S, Cocco L, Vitale M (2002). Noradrenergic and cholinergic innervation of the bone marrow. Int J Mol Med, 10(1): 77–80
Baron M H, Vacaru A, Nieves J (2013). Erythroid development in the mammalian embryo. Blood Cells Mol Dis, 51(4): 213–219
Bauer A, Tronche F, Wessely O, Kellendonk C, Reichardt H M, Steinlein P, Schütz G, Beug H (1999). The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev, 13(22): 2996–3002
Beguin Y, Jaspers A (2014). Iron sucrose- characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas. Expert Opin Pharmacother, 15(14): 2087–2103
Boer A K, Drayer A L, Rui H, Vellenga E (2002). Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Blood, 100(2): 467–473
Boer A K, Drayer A L, Vellenga E (2003). cAMP/PKA-mediated regulation of erythropoiesis. Leuk Lymphoma, 44(11): 1893–1901
Böhmer R M (2004). IL-3-dependent early erythropoiesis is stimulated by autocrine transforming growth factor beta. Stem Cells, 22(2): 216–224
Brown S W, Meyers R T, Brennan K M, Rumble J M, Narasimhachari N, Perozzi E F, Ryan J J, Stewart J K, Fischer-Stenger K (2003). Catecholamines in a macrophage cell line. J Neuroimmunol, 135(1-2): 47–55
Burdach S E, Levitt L J (1987). Receptor-specific inhibition of bone marrow erythropoiesis by recombinant DNA-derived interleukin-2. Blood, 69(5): 1368–1375
Chasis J A, Mohandas N (2008). Erythroblastic islands: niches for erythropoiesis. Blood, 112(3): 470–478
Chen D, Zhang G (2001). Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis. Exp Hematol, 29(8): 971–980
Cheung J Y, Miller B A (2001). Molecular mechanisms of erythropoietin signaling. Nephron, 87(3): 215–222
Choobineh H, Dehghani S, Alizadeh S, Dana V G, Saiepour N, Meshkani R, Einollahi N (2009). Evaluation of Leptin Levels in Major beta-Thalassemic Patients. Int J Hematol Oncol Stem Cell Res, 3(4): 1–4
Chuang T T, Sallese M, Ambrosini G, Parruti G, De Blasi A (1992). High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. J Biol Chem, 267(10): 6886–6892
Claycombe K, King L E, Fraker P J (2008). A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci U S A, 105(6): 2017–2021
Cole S W, Sood A K (2012). Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res, 18(5): 1201–1206
Cosentino M, Bombelli R, Ferrari M, Marino F, Rasini E, Maestroni G J M, Conti A, Boveri M, Lecchini S, Frigo G (2000). HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines. Life Sci, 68(3): 283–295
Cremaschi G A, Gorelik G, Klecha A J, Lysionek A E, Genaro A M (2000). Chronic stress influences the immune system through the thyroid axis. Life Sci, 67(26): 3171–3179
Dart A M, Du X J, Kingwell, B A (2002). Gender, sex hormones and autonomic nervous control of the cardiovascular system. Cardiovasc Res, 53(3):678–687
Donahue R E, Yang Y C, Clark S C (1990). Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation. Blood, 75(12): 2271–2275
Elenkov I J, Chrousos G P (1999). Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab, 10(9): 359–368
Elenkov I J, Chrousos G P (2002). Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci, 966(1): 290–303
Elhassan I O, Hannoush E J, Sifri Z C, Jones E, AlzateWD, Rameshwar P, Livingston D H, Mohr A M (2011). Beta-blockade prevents hematopoietic progenitor cell suppression after hemorrhagic shock. Surg Infect (Larchmt), 12(4): 273–278
Farmer P, Pugin J (2000). b-adrenergic agonists exert their “antiinflammatory” effects in monocytic cells through the IkappaB/NFkappaB pathway. Am J Physiol Lung Cell Mol Physiol, 279(4): L675–L682
Fink G D, Paulo L G, Fisher J W (1975). Effects of beta adrenergic blocking agents on erythropoietin production in rabbits exposed to hypoxia. J Pharmacol Exp Ther, 193(1): 176–181
Fitch S R, Kimber G M, Wilson N K, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky A, Dzierzak E, Ottersbach K (2012). Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Cell Stem Cell, 11(4): 554–566
Flierl M A, Rittirsch D, Nadeau B A, Sarma J V, Day D E, Lentsch A B, Huber-Lang M S, Ward P A (2009). Upregulation of phagocytederived catecholamines augments the acute inflammatory response. PLoS One, 4(2): e4414
Fonseca R B, Mohr A M, Wang L, Sifri Z C, Rameshwar P, Livingston D H (2005). The impact of a hypercatecholamine state on erythropoiesis following severe injury and the role of IL-6. J Trauma, 59(4): 884–889, discussion 889–890
Francis K T (1981). The relationship between high and low trait psychological stress, serum testosterone, and serum cortisol. Experientia, 37(12): 1296–1297
Freudenthaler S M, Schenck T, Lucht I, Gleiter C H (1999). Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system. Br J Clin Pharmacol, 48(4): 631–634
Furmanski P, Johnson C S (1990). Macrophage control of normal and leukemic erythropoiesis: identification of the macrophage-derived erythroid suppressing activity as interleukin-1 and the mediator of its in vivo action as tumor necrosis factor. Blood, 75(12): 2328–2334
Ge X H, Zhu G J, Geng D Q, Zhang Z J, Liu C F (2012). Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3ß-mediated mitochondrial translocation of Bax in PC12 cells. Neurol Sci, 33(6): 1249–1256
Gebhard C, Petroktistis F, Zhang H, Kammerer D, Köhle C, Klingel K, Albinus M, Gleiter C H, Osswald H, Grenz A (2006). Role of renal nerves and salt intake on erythropoietin secretion in rats following carbon monoxide exposure. J Pharmacol Exp Ther, 319(1): 111–116
Glass N E, Kaltenbach L A, Fleming S B, Arbogast P G, Cotton B A (2012). The impact of beta-blocker therapy on anemia after traumatic brain injury. Transfusion, 52(10): 2155–2160
Guo W, Bachman E, Li M, Roy C N, Blusztajn J, Wong S, Chan S Y, Serra C, Jasuja R, Travison T G, Muckenthaler M U, Nemeth E, Bhasin S (2013). Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell, 12(2): 280–291
Hajifathali A, Saba F, Atashi A, Soleimani M, Mortaz E, Rasekhi M (2014). The role of catecholamines in mesenchymal stem cell fate. Cell Tissue Res, 358(3): 651–665
Hamill R W, Schroeder B (1990). Hormonal regulation of adult sympathetic neurons: the effects of castration on neuropeptide Y, norepinephrine, and tyrosine hydroxylase activity. J Neurobiol, 21(5): 731–742
Hattangadi S M, Wong P, Zhang L, Flygare J, Lodish H F(2011). From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood, 118(24): 6258–6268
Hetier E, Ayala J 1, Boußseau A, Prochiantz A 1 (1991). Modulation of interleukin-1 and tumor necrosis factor expression by ß-adrenergic agonists in mouse ameboid microglial cells. Exp Brain Res, 86(2): 407–413
Huntgeburth M, Tiemann K, Shahverdyan R, Schlüter K D, Schreckenberg R, Großs M L, Mödersheim S, Caglayan E, Müller-Ehmsen J, Ghanem A, Vantler M, Zimmermann W H, Böhm M, Rosenkranz S (2011). Transforming growth factor ß1 oppositely regulates the hypertrophic and contractile response to ß-adrenergic stimulation in the heart. PLoS One, 6(11): e26628
Ikuyama S (2005). Effects of thyroid hormone on hematopoiesis. Nihon Rinsho, 63(Suppl 10): 84–87
Isern J, Méndez-Ferrer S (2011). Stem cell interactions in a bone marrow niche. Curr Osteoporos Rep, 9(4): 210–218
Jewell M, Breyer R M, Currie K P (2012). Bidirectional regulation of adrenal catecholamine release by prostaglandin E2. FASEB J, 26(1): 879.876
Kahn B B, Minokoshi Y (2013). Leptin, GABA, and glucose control. Cell Metab, 18(3): 304–306
Kalinkovich A, Spiegel A, Shivtiel S, Kollet O, Jordaney N, Piacibello W, Lapidot T (2009). Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34 + cells by the nervous system. Brain Behav Immun, 23(8): 1059–1065
Kaneko K, Furuyama K, Aburatani H, Shibahara S (2009). Hypoxia induces erythroid-specific 5-aminolevulinate synthase expreßsion in human erythroid cells through transforming growth factor-ß signaling. FEBS J, 276(5): 1370–1382
Katayama Y, Battista M, Kao WM, Hidalgo A, Peired A J, Thomas S A, Frenette P S (2006). Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell, 124(2): 407–421
Kefaloyianni E, Gaitanaki C, Beis I (2006). ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal, 18(12): 2238–2251
Kelesidis T, Kelesidis I, Chou S, Mantzoros C S (2010). Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med, 152(2): 93–100
Kilroy G E, Foster S J, Wu X, Ruiz J, Sherwood S, Heifetz A, Ludlow J W, Stricker D M, Potiny S, Green P, Halvorsen Y D C, Cheatham B, Storms R W, Gimble JM(2007). Cytokine profile of human adiposederived stem cells: expression of angiogenic, hematopoietic, and proinflammatory factors. J Cell Physiol, 212(3): 702–709
Kim Y J, Hur E M, Park T J, Kim K T (2000). Nongenomic inhibition of catecholamine secretion by 17beta-estradiol in PC12 cells. J Neurochem, 74(6): 2490–2496
Knutson K L, Spiegel K, Penev P, Van Cauter E (2007). The metabolic consequences of sleep deprivation. Sleep Med Rev, 11(3): 163–178
Kuçi Z, Seitz G, Kuçi S, Kreyenberg H, Schumm M, Lang P, Niethammer D, Handgretinger R, Bruchelt G (2006). Pitfalls in detection of contaminating neuroblastoma cells by tyrosine hydroxylase RT-PCR due to catecholamine-producing hematopoietic cells. Anticancer Res, 26(3A): 2075–2080
Laharrague P, Larrouy D, Fontanilles A M, Truel N, Campfield A, Tenenbaum R, Galitzky J, Corberand J X, Pénicaud L, Casteilla L (1998). High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J, 12(9): 747–752
Lambert L A, Perri H, Halbrooks P J, Mason A B (2005). Evolution of the transferrin family: conservation of residues associated with iron and anion binding. Comp Biochem Physiol B Biochem Mol Biol, 142(2): 129–141
Leng H M J, Kidson S H, Keraan M M, Randall G W, Folb P I (1996). Cytokine-mediated inhibition of erythropoietin synthesis by dexamethasone. J Pharm Pharmacol, 48(9): 971–974
Leung P, Gidari A S, (1981). Glucocorticoids inhibit erythroid colony formation by murine fetal liver erythroid progenitor cells in vitro. Endocrinology, 108(5): 1787–1794
Maestroni G J, Cosentino M, Marino F, Togni M, Conti A, Lecchini S, Frigo G (1998). Neural and endogenous catecholamines in the bone marrow. Circadian association of norepinephrine with hematopoiesis? Exp Hematol, 26(12): 1172–1177
Magiakou M A, Smyrnaki P, Chrousos G P (2006). Hypertension in Cushing’s syndrome. Best Pract Res Clin Endocrinol Metab, 20(3): 467–482
Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas F Jr, Tabira T, Sasaki R (1993). Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem, 268(15): 11208–11216
McCranor B J, Kim M J, Cruz N M, Xue Q L, Berger A E, Walston J D, Civin C I, Roy C N (2014). Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells. Blood Cells Mol Dis, 52(2–3): 126–133
Mei Y, Yin N, Jin X, He J, Yin Z (2013). The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology, 154(12): 4640–4649
Méndez-Ferrer S, Battista M, Frenette P S (2010). Cooperation of beta (2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization. Ann N Y Acad Sci, 1192(1): 139–144
Méndez-Ferrer S, Michurina T V, Ferraro F, Mazloom A R, Macarthur B D, Lira S A, Scadden D T, Ma’ayan A, Enikolopov G N, Frenette P S (2010). Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature, 466(7308): 829–834
Mikhail A A, Beck E X, Shafer A, Barut B, Smith Gbur J, Zupancic T J, Snodgrass H R (1997). Leptin stimulates fetal and adult erythroid and myeloid development. Blood, 89(5):1507–1512
Miller A H, Maletic V, Raison C L (2009). Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry, 65(9): 732–741
Mladenovic J, Adamson J W (1984). Adrenergic modulation of erythropoiesis: in vitro studies of colony-forming cells in normal and polycythaemic man. Br J Haematol, 56(2): 323–332
Moura I C, Hermine O, Lacombe C, Mayeux P (2015). Erythropoiesis and transferrin receptors. Curr Opin Hematol, 22(3): 193–198
Muta K, Krantz S, Bondurant M, Dai C (1995). Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation. Blood, 86(2):572–580
Nardelli J, Thiesson D, Fujiwara Y, Tsai F Y, Orkin S H (1999). Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol, 210(2): 305–321
Nemeth E, Valore E V, Territo M, Schiller G, Lichtenstein A, Ganz T (2003). Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 101(7): 2461–2463
Nezu M, Souma T, Yamamoto M (2014). Renal erythropoietinproducing cells and kidney disease. Nihon Rinsho, 72(9): 1691–1700 (Renal erythropoietin-producing cells and kidney disease)
Obayashi K, Ando Y, Terazaki H, Yamashita T, Nakamura M, Suga M, Uchino M, Ando M (2000). Mechanism of anemia associated with autonomic dysfunction in rats. Auton Neurosci, 82(3): 123–129
Oddo M, Levine J M, Kumar M, Iglesias K, Frangos S, Maloney-Wilensky E, Le Roux P D (2012). Anemia and brain oxygen after severe traumatic brain injury. Intensive Care Med, 38(9): 1497–1504
Oehler L, Kollars M, Bohle B, Berer A, Reiter E, Lechner K, Geissler K (1999). Interleukin-10 inhibits burst-forming unit-erythroid growth by suppression of endogenous granulocyte-macrophage colonystimulating factor production from T cells. Exp Hematol, 27(2): 217–223
Otero M, Lago R, Lago F, Casanueva F F, Dieguez C, Gómez-Reino J J, Gualillo O (2005). Leptin, from fat to inflammation: old questions and new insights. FEBS Lett, 579(2): 295–301
Pandolfi P P, Roth M E, Karis A, Leonard M W, Dzierzak E, Grosveld F G, Engel J D, Lindenbaum M H (1995). Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet, 11(1): 40–44
Pasupuleti L V, Cook K M, Sifri Z C, Alzate W D, Livingston D H, Mohr A M (2014). Do all ß-blockers attenuate the excess hematopoietic progenitor cell mobilization from the bone marrow following trauma/hemorrhagic shock? J Trauma Acute Care Surg, 76(4): 970–975
Peeling P, Dawson B, Goodman C, Landers G, Trinder D (2008). Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones. Eur J Appl Physiol, 103(4): 381–391
Penn A, Mohr A M, Shah S G, Sifri Z C, Kaiser V L, Rameshwar P, Livingston D H (2010). Dose-response relationship between norepinephrine and erythropoiesis: evidence for a critical threshold. J Surg Res, 163(2): e85–e90
Peruzzo D C, Benatti B B, Antunes I B, Andersen M L, Sallum E A, Casati MZ, Nociti F H Jr, Nogueira-Filho G R (2008). Chronic stress may modulate periodontal disease: a study in rats. J Periodontol, 79(4): 697–704
Popovic WJ, Brown J E, Adamson JW (1977). The influence of thyroid hormones on in vitro erythropoiesis. Mediation by a receptor with beta adrenergic properties. J Clin Invest, 60(4): 907–913
Provalova N V, Skurikhin E G, Pershina O V, Minakova M Y, Suslov N I, Dygai A M (2003). Possible mechanisms underlying the effect of natural preparations on erythropoiesis under conditions of conflict situation. Bull Exp Biol Med, 136(2): 165–169
Provalova N V, Skurikhin E G, Pershina O V, Suslov N I, Minakova M Y, Dygai A M, Gol’dberg E D (2002). Mechanisms underling the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation. Bull Exp Biol Med, 133(5): 428–432
Quesniaux V F, Clark S C, Turner K, Fagg B (1992). Interleukin-11 stimulates multiple phases of erythropoiesis in vitro. Blood, 80(5): 1218–1223
Ricci M R, Lee M J, Russell C D, Wang Y, Sullivan S, Schneider S H, Fried S K (2005). Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 288(4): E798–804
Rivier C, Vale W, Brown M (1989). In the rat, interleukin-1 a and-ß stimulate adrenocorticotropin and catecholamine release. Endocrinology, 125(6): 3096–3102
Rosenbaum D M, Rasmussen S G, Kobilka B K (2009). The structure and function of G-protein- receptors. Nature, 459(7245): 356–363
Rubio-Perez J M, Morillcoupledas-Ruiz J M (2012). A review: inflammatory process in Alzheimer’s disease, role of cytokines. ScientificWorld- Journal, 2012: 756357
Rusten L S, Jacobsen S E (1995). Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors. Blood, 85(4): 989–996
Saba F, Soleimani M, Atashi A, Mortaz E, Shahjahani M, Roshandel E, Jaseb K, Saki N (2013). The role of the nervous system in hematopoietic stem cell mobilization. Lab Hematol, 19(3): 8–16
Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda R C, Schwaller J, Méndez-Ferrer S (2014). Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell, 15(6): 791–804
Sandrini S M, Shergill R, Woodward J, Muralikuttan R, Haigh R D, Lyte M, Freestone P P (2010). Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin. J Bacteriol, 192(2): 587–594
Schneider H, Chaovapong W, Matthews DJ, Karkaria C, Cass R T, Zhan H, Boyle M, Lorenzini T, Elliott S G, Giebel L B.(1997). Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. Blood, 89(2):473–482
Scholz H, Schurek H J, Eckardt K U, Kurtz A, Bauer C (1991). Oxygendependent erythropoietin production by the isolated perfused rat kidney. Pflugers Arch, 418(3): 228–233
Schraml E, Fuchs R, Kotzbeck P, Grillari J, Schauenstein K (2009). Acute adrenergic stress inhibits proliferation of murine hematopoietic progenitor cells via p38/MAPK signaling. Stem Cells Dev, 18(2): 215–227
Schulte H M, Bamberger C M, Elsen H, Herrmann G, Bamberger A M, Barth J (1994). Systemic interleukin-1 a and interleukin-2 secretion in response to acute stress and to corticotropin-releasing hormone in humans. Eur J Clin Invest, 24(11): 773–777
Silva J E, Bianco S D (2008). Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid, 18(2): 157–165
Silverboard H, Aisiku I, Martin G S, Adams M, Rozycki G, Moss M (2005). The role of acute blood transfusion in the development of acute respiratory distress syndrome in patients with severe trauma. J Trauma, 59(3): 717–723
Skurikhin E G, Dygai A M, Provalova N V, Minakova M Y, Suslov N I (2005). Mechanisms of regulation of erythropoiesis during experimental neuroses. Bull Exp Biol Med, 139(5): 543–549
Skurikhin E G, Pershina O V, Minakova MY, Ermakova N N, Firsova T V, Dygai A M, Gol’dberg E D (2008). Adrenergic regulation of erythropoiesis during cytostatic-induced myelosuppressions. Bull Exp Biol Med, 146(4): 405–410
Spiegel A, Shivtiel S, Kalinkovich A, Ludin A, Netzer N, Goichberg P, Azaria Y, Resnick I, Hardan I, Ben-Hur H, Nagler A, Rubinstein M, Lapidot T (2007). Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nat Immunol, 8(10): 1123–1131
Stark J L, Avitsur R, Padgett D A, Campbell K A, Beck F M, Sheridan J F (2001). Social stress induces glucocorticoid resistance in macrophages. Am J Physiol Regul Integr Comp Physiol, 280(6): R1799–R1805
Stellacci E, Di Noia A, Di Baldassarre A, Migliaccio G, Battistini A, Migliaccio A R (2009). Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol, 37(5): 559–572
Tan K S, Nackley A G, Satterfield K, Maixner W, Diatchenko L, Flood P M (2007). b2 adrenergic receptor activation stimulates proinflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal, 19(2): 251–260
Togo M, Tsukamoto K, Satoh H, Hara M, Futamura A, Nakarai H, Nakahara K, Hashimoto Y (1999). Relationship between levels of leptin and hemoglobin in Japanese men. Blood, 93(12): 4444–4445
Tsarovina K, Pattyn A, Stubbusch J, Müller F, van der Wees J, Schneider C, Brunet J F, Rohrer H (2004). Essential role of Gata transcription factors in sympathetic neuron development. Development, 131(19): 4775–4786
Tsiftsoglou A S, Gusella J F, Volloch V, Housman D E (1979). Inhibition by dexamethasone of commitment to erythroid differentiation in murine erythroleukemia cells. Cancer Res, 39(10): 3849–3855
Tsigos C, Chrousos G P (2002). Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res, 53(4): 865–871
Unlap T, Jope R S (1995). Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain. Neurosci Lett, 198(1): 41–44
Vanasse G J, Jeong J Y, Tate J, Bathulapalli H, Anderson D, Steen H, Fleming M, Mattocks K, Telenti A, Fellay J, Justice A C, Berliner N (2011). A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood, 118(20): 5401–5408
Villanueva E C, Myers M G Jr (2008). Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond), 32(Suppl 7): S8–S12
von Lindern M, Zauner W, Mellitzer G, Steinlein P, Fritsch G, Huber K, Löwenberg B, Beug H(1999). The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood, 94(2):550–559
von Wussow U, Klaus J, Pagel H (2005). Is the renal production of erythropoietin controlled by the brain stem? Am J Physiol Endocrinol Metab, 289(1): E82–E86
Voorhees J L, Powell N D, Moldovan L, Mo X, Eubank T D, Marsh C B (2013). Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation. PLoS One, 8(10): e77935
Walters M R, Sharma R (2003). Cross-talk between beta-adrenergic stimulation and estrogen receptors: isoproterenol inhibits 17betaestradiol- induced gene transcription in A7r5 cells. J Cardiovasc Pharmacol, 42(2): 266–274
Wei C, Zhou J, Huang X, LiM(2008). Effects of psychological stress on serum iron and erythropoiesis. Int J Hematol, 88(1): 52–56
White L D, Lawson E E (1997). Effects of chronic prenatal hypoxia on tyrosine hydroxylase and phenylethanolamine N-methyltransferase messenger RNA and protein levels in medulla oblongata of postnatal rat. Pediatr Res, 42(4): 455–462
Wohleb E S, Hanke M L, Corona A W, Powell N D, Stiner L M, Bailey M T, Nelson R J, Godbout J P, Sheridan J F (2011). b-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci, 31(17): 6277–6288
Woiciechowsky C, Schöning B, Lanksch W R, Volk H D, Döcke W D (1999). Catecholamine-induced interleukin-10 release: a key mechanism in systemic immunodepression after brain injury. Crit Care, 3(6): R107
Yanagihara N, Toyohira Y, Ueno S, Tsutsui M, Utsunomiya K, Liu M, Tanaka K (2005). Stimulation of catecholamine synthesis by environmental estrogenic pollutants. Endocrinology, 146(1): 265–272
Yang Q, Jian J, Katz S, Abramson S B, Huang X (2012). 17ß-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology, 153(7): 3170–3178
Yasuda Y, Masuda S, Chikuma M, Inoue K, Nagao M, Sasaki R (1998). Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis. J Biol Chem, 273(39): 25381–25387
Yokoyama T, Etoh T, Kitagawa H, Tsukahara S, Kannan Y (2003). Migration of erythroblastic islands toward the sinusoid as erythroid maturation proceeds in rat bone marrow. J Vet Med Sci, 65(4): 449–452
Zhao M, Chen J, Wang W, Wang L, Ma L, Shen H, Li M (2008). Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats. Biochem Biophys Res Commun, 373(1): 90–93
Zouhal H, Lemoine-Morel S, Mathieu M E, Casazza G A, Jabbour G (2013). Catecholamines and obesity: effects of exercise and training. Sports Med, 43(7): 591–600
Acknowledgements
We would like to thank all our colleagues in the Department of Hematology in Tarbiat Modares University for assistance with the manuscript and Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences.
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Saba, F., Saki, N., Khodadi, E. et al. Crosstalk between catecholamines and erythropoiesis. Front. Biol. 12, 103–115 (2017). https://doi.org/10.1007/s11515-017-1428-4
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DOI: https://doi.org/10.1007/s11515-017-1428-4