Abstract
We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and α- and β-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 5, pp. 495–501, May, 2005
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Skurikhin, E.G., Dygai, A.M., Provalova, N.V. et al. Mechanisms of Regulation of Erythropoiesis during Experimental Neuroses. Bull Exp Biol Med 139, 543–549 (2005). https://doi.org/10.1007/s10517-005-0341-z
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DOI: https://doi.org/10.1007/s10517-005-0341-z