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NMDA receptor signaling: death or survival?

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Frontiers in Biology

Abstract

Glutamate-induced neuronal damage is mainly caused by overactivation of N-methyl-D-aspartate (NMDA) receptors. Conversely, normal physiological brain function and neuronal survival require adequate activation of NMDA receptors. Studies have revealed that NMDA receptor-induced neuronal death or survival is mediated through distinct subset of NMDA receptors triggering different intracellular signaling pathways. Here we discuss recent advances in the characterization of NMDA receptors in neuronal protection, emphasizing subunit-specific role, which contributes to temporal-spatial distribution, subcellular localization and diverse channel properties of NMDA receptors.

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  1. Institute of Molecular Medicine and Genetics, Department of Neurology, Georgia Health Sciences University, Augusta, GA, 30912, USA

    Tong Luo, Wei-Hua Wu & Bo-Shiun Chen

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  2. Wei-Hua Wu
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Correspondence to Wei-Hua Wu or Bo-Shiun Chen.

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Luo, T., Wu, WH. & Chen, BS. NMDA receptor signaling: death or survival?. Front. Biol. 6, 468–476 (2011). https://doi.org/10.1007/s11515-011-1187-6

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