Abstract
Neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.
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References
Abidian MR, Kim, DH, Martin DC (2006) Conducting-polymer nanotubes for controlled drug release. Adv Mater 18:405–409
Aliabadi HM, Lavasanifar A (2006) Polymeric micelles for drug delivery. Expert Opin Drug Deliv 3:139–162
Allen TM, Cullis PR (2004) Drug delivery systems: entering the mainstream. Science 303:1818–1822
Armstrong A, Brewer J, Newman C, Alakhov V, Pietrzynski G, Campbell S, Corrie P, Ranson M, Valle JW (2006) SP1049C as first-line therapy in advanced (inoperable or metastatic) adenocarcinoma of the oesophagus: a phase II window study. J Clin Oncol (Meeting Abstracts) 24:4080
Batrakova EV, Han HY, Miller DW, Kabanov AV (1998) Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells. Pharm Res 15:1525–1532
Batrakova EV, Miller DW, Li S, Alakhov VY, Kabanov AV, Elmquist WF (2001) Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies. J Pharmacol Exp Ther 296:551–557
Batrakova EV, Vinogradov SV, Robinson SM, Niehoff ML, Banks WA, Kabanov AV (2005) Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem 16:793–802
Batrakova EV, Li S, Reynolds AD, Mosley RL, Bronich TK, Kabanov AV, Gendelman HE (2007) A macrophage-nanozyme delivery system for Parkinson’s disease. Bioconjug Chem 18(5):1498–1506
Baxendale M (2003) Biomolecular applications of carbon nanotubes. IEE Proc Nanobiotechnol 150:3–8
Blass J (2003) Cerebrometabolic abnormalities in Alzheimer’s disease. Neurol Res 25:556–566
Bronich TK, Kabanov AV, Kabanov VA, Yu K, Eisenberg A (1997) Soluble complexes from poly(ethylene oxide)-block-polymethacrylate anions and N-alkylpyridinium cations. Macromolecules 30:3519–3525
Bronich TK, Cherry T, Vinogradov SV, Eisenberg A, Kabanov VA, Kabanov AV (1998) Self-assmbly in mixtures of poly(ethylene oxide)-graft-poly(ethyleneimine) and alkyl sulfates. Langmuir 14:6101–6106
Bronich TK, Nehls A, Eisenberg A, Kabanov VA, Kabanov AV (1999) Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge. Colloids Surf B 16:243–251
Bronich TK, Popov AM, Eisenberg A, Kabanov VA, Kabanov AV (2000) Effects of block length and structure of surfactant on self-assembly and solution behavior of block ionomer complexes. Langmuir 16:481–489
Buyukserin F, Kang M, Martin CR (2007) Plasma-etched nanopore polymer films and their use as templates to prepare “nano test tubes”. Small 3:106–110
Chekhonin V, Zhirkov YA, Gurina OI, Ryabukhin IA, Lebedev SV, Kashparov IA, Dmitriyeva TB (2005) PEGylated immunoliposomes directed against brain astrocytes. Drug Deliv 12:1–6
Cui Z, Lockman PR, Atwood CS, Hsu CH, Gupte A, Allen DD, Mumper RJ (2005) Novel d-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer’s and other CNS diseases. Eur J Pharm Biopharm 59:263–272
D’Emanuele A, Attwood D (2005) Dendrimer–drug interactions. Adv Drug Deliv Rev 57:2147–2162
Daleke DL, Hong K, Papahadjopoulos D (1990) Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assay. Biochim Biophys Acta 1024:352–366
Danson S, Ferry D, Alakhov V, Margison J, Kerr D, Jowle D, Brampton M, Halbert G, Ranson M (2004) Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. Br J Cancer 90:2085–2091
de Boer AG, Gaillard PJ (2007) Drug targeting to the brain. Annu Rev Pharmacol Toxicol 47:323–355
Ding JJ, Guo CY, Cai QL, Lin YH, Wang H (2005) In vivo expression of green fluorescent protein gene and immunogenicity of ES312 vaccine both mediated by starburst polyamidoamine dendrimers. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:499–503
Dou H, Destache CJ, Morehead JR, Mosley RL, Boska MD, Kingsley J, Gorantla S, Poluektova L, Nelson JA, Chaubal M, Werling J, Kipp J, Rabinow BE, Gendelman HE (2006) Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery. Blood 108:2827–2835
Dou H, Morehead J, Destache CJ, Kingsley JD, Shlyakhtenko L, Zhou Y, Chaubal M, Werling J, Kipp J, Rabinow BE, Gendelman HE (2007) Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages. Virology 358:148–158
Dugan LL, Turetsky DM, Du C, Lobner D, Wheeler M, Almli CR, Shen CK, Luh TY, Choi DW, Lin TS (1997) Carboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci USA 94:9434–9439
Dugan L, Lovett EG, Quick KL, Lotharius J, Lin TT, O, Malley KL (2001) Fullerene-based antioxidants and neurodegenerative disorders. Parkinsonism Relat Disord 7:243–246
Ellis-Behnke RG, Liang YX, You SW, Tay DK, Zhang S, So KF, Schneider GE (2006) Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci USA 103:5054–5059
Fenoglio I, Tomatis M, Lison D, Muller J, Fonseca A, Nagy JB, Fubini B (2006) Reactivity of carbon nanotubes: Free radical generation or scavenging activity. Free Radic Biol Med 40:1227–1233
Feynman RP (1960) There’s plenty of room at the bottom. Eng Sci 23:22–36
Fortin D (2003) Altering the properties of the blood–brain barrier: disruption and permeabilization. Prog Drug Res 61:125–154
Gabizon AA, Shmeeda H, Zalipsky S (2006) Pros and cons of the liposome platform in cancer drug targeting. J Liposome Res 16:175–183
Gorantla S, Dou H, Boska M, Destache CJ, Nelson J, Poluektova L, Rabinow BE, Gendelman HE, Mosley RL (2006) Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery. J Leukoc Biol 80:1165–1174
Gradishar WJ (2006) Albumin-bound paclitaxel: a next-generation taxane. Expert Opin Pharmacother 7:1041–1053
Greiner A, Wendorff JH, Yarin AL, Zussman E (2006) Biohybrid nanosystems with polymer nanofibers and nanotubes. Appl Microbiol Biotechnol 71:387–393
Haensler J, Szoka FC (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconj Chem 4:372–379
Hahn U, Gorka M, Vogtle F, Vicinelli V, Ceroni P, Maestri M, Balzani V (2002) Light-harvesting dendrimers: efficient intra- and intermolecular energy-transfer processes in a species containing 65 chromophoric groups of four different types. Angew Chem Int Ed Engl 41:3595–3598, 3514
Harada A, Kataoka K (1999a) Novel polyion complex micelles entrapping enzyme molecules in the core. 2. Characterization of the micelles prepared at nonstoichiometric mixing ratios. Langmuir 15:4208–4212
Harada A, Kataoka K (1999b) Chain length recognition: core-shell supramolecular assembly from oppositely charged block copolymers. Science 283:65–67
Harada-Shiba M, Yamauchi K, Harada A, Takamisawa I, Shimokado K, Kataoka K (2002) Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer. Gene Ther 9:407–414
Hartgerink J, Granja JR, Milligan RA, Ghadiri MR (1996) Self-assembling peptide nanotubes. J Am Chem Soc 118:43–50
Hirsch A (2003) Dendrimeric fullerene derivatives, process for their preparation, and use as neuroprotectants. In: Siemens Axiva GmbH KG (DE), USA
Hirsch A, Brettreich M, Wudl F (2005) Fullerenes: chemistry and reactions. In: Wiley-VCH Verlag GmbH KGaA
Hou S, Wang J, Martin CR (2005a) Template-synthesized DNA nanotubes. J Am Chem Soc 127:8587–8587
Hou S, Wang J, Martin CR (2005b) Template-synthesized protein nanotubes. Nano Lett 5:231–234
Huang RQ, Qu YH, Ke WL, Zhu JH, Pei YY, Jiang C (2007) Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Faseb J 21:1117–1125
Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354:56–58
Jain S, Mishra V, Singh P, Dubey PK, Saraf DK, Vyas SP (2003) RGD-anchored magnetic liposomes for monocytes/neutrophils-mediated brain targeting. Int J Pharm 261:43–55
Jang J, Ko S, Kim Y (2006) Dual-functionalized polymer nanotubes as substrates for molecular-probe and DNA-carrier applications. Adv Funct Mater 16:154–159
Jaturanpinyo M, Harada A, Yuan X, Kataoka K (2004) Preparation of bionanoreactor based on core-shell structured polyion complex micelles entrapping trypsin in the core cross-linked with glutaraldehyde. Bioconjug Chem 15:344–348
Jean MJF (2003) Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology. J Polym Sci A Polym Chem 41:3713–3725
Jin H, Chen WQ, Tang XW, Chiang LY, Yang CY, Schloss JV, Wu JY (2000) Polyhydroxylated C(60), fullerenols, as glutamate receptor antagonists and neuroprotective agents. J Neurosci Res 62:600–607
Junghans M, Loitsch SM, Steiniger SC, Kreuter J, Zimmer A (2005) Cationic lipid-protamine-DNA (LPD) complexes for delivery of antisense c-myc oligonucleotides. Eur J Pharm Biopharm 60:287–294
Kabanov AV, Alakhov VY (2002) Pluronic block copolymers in drug delivery: from micellar nanocontainers to biological response modifiers. Crit Rev Ther Drug Carrier Syst 19:1–72
Kabanov AV, Gendelman HE (2007) Nanomedicine in the diagnosis and therapy of neurodegenerative disorders. Prog Polym Sci 32:1054–1082
Kabanov A, Chekhonin VP, Alakhov VYu, Batrakova EV, Lebedev AS, Melik-Mubarov NS, Arzhakov SA, Levashov AV, Morozov GV, Severin ES et al (1989) The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett 258:343–345
Kabanov AV, Vinogradov SV, Suzdaltseva YG, Alakhov V (1995) Water-soluble block polycations as carriers for oligonucleotide delivery. Bioconjug Chem 6:639–643
Kadiu I, Glanzer JG, Kipnis J, Gendelman HE, Thomas MP (2005) Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotox Res 8:25–50
Kataoka K, Harada A, Nagasaki Y (2001) Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 47:113–131
Kim TY, Kim DW, Chung JY, Shin SG, Kim SC, Heo DS, Kim NK, Bang YJ (2004) Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies. Clin Cancer Res 10:3708–3716
Kitchens KM, El-Sayed ME, Ghandehari H (2005) Transepithelial and endothelial transport of poly (amidoamine) dendrimers. Adv Drug Deliv Rev 57:2163–2176
Kokovay E, Cunningham LA (2005) Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson’s disease. Neurobiol Dis 19:471–478
Kreuter J, Ramge P, Petrov V, Hamm S, Gelperina SE, Engelhardt B, Alyautdin R, von Briesen H, Begley DJ (2003) Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm Res 20:409–416
Kroto HW, Heath JR, O, Brien SC, Curl RF, Smalley RE (1985) C60: buckminsterfullerene. Nature 318:162–163
Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, Czlonkowska A (1999a) MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson’s disease. Acta Neurobiol Exp (Wars) 59:1–8
Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, Czlonkowska A (1999b) The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse. Exp Neurol 156:50–61
Kwon GS (2003) Polymeric micelles for delivery of poorly water-soluble compounds. Crit Rev Ther Drug Carrier Syst 20:357–403
Lacerda L, Bianco A, Prato M, Kostarelos K (2006) Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Deliv Rev 58:1460–1470
Lawson LJ, Perry VH, Gordon S (1992) Turnover of resident microglia in the normal adult mouse brain. Neuroscience 48:405–415
Liang Z, Susha AS, Yu A, Caruso F (2003) Nanotubes prepared by layer-by-layer coating of porous membrane templates. Adv Mater 15:1849–1853
Liu M, Kono K, Frechet JM (2000) Water-soluble dendritic unimolecular micelles: their potential as drug delivery agents. J Control Release 65:121–131
Lockman P, Mumper RJ, Khan MA, Allen DD (2002) Nanoparticle technology for drug delivery across the blood brain barrier. Drug Dev Ind Pharm 28:1–13
Lovat V, Pantarotto D, Lagostena L, Cacciari B, Grandolfo M, Righi M, Spalluto G, Prato M, Ballerini L (2005) Carbon nanotube substrates boost neuronal electrical signaling. Nano Lett 5:1107–1110
Male D, Rezaie P (2001) Colonisation of the human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules. Prog Brain Res 132:81–93
Martin C (1994) Nanomaterials: a membrane-Based synthetic approach. Science 266:1961–1966
Martin CR, Kohli P (2003) The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2:29–37
Matsumoto K, Sato C, Naka Y, Kitazawa A, Whitby RL, Shimizu N (2007) Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes. J Biosci Bioeng 103:216–220
Matsumura Y (2006) Micelle carrier system in clinical trial. Nippon Rinsho 64:316–321
Matsumura Y, Hamaguchi T, Ura T, Muro K, Yamada Y, Shimada Y, Shirao K, Okusaka T, Ueno H, Ikeda M, Watanabe N (2004) Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br J Cancer 91:1775–1781
Maurer N, Fenske DB, Cullis PR (2001) Developments in liposomal drug delivery systems. Expert Opin Biol Ther 1:923–947
Mayeux R (2003) Epidemiology of neurodegeneration. Annu Rev Neurosci 26:81–104
Metodiewa D, Koska C (2000) Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxic events and neurologic disorders. An overview. Neurotox Res 1:197–233
Nguyen HK, Lemieux P, Vinogradov SV, Gebhart CL, Guerin N, Paradis G, Bronich TK, Alakhov VY, Kabanov AV (2000) Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther 7:126–138
Oberdorster E (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 112:1058–1062
Oberlin A, Endo M, Koyama T (1976) Filamentous growth of carbon through benzene decomposition. J Cryst Growth 32:335–349
Oh KT, Bronich TK, Bromberg L, Hatton TA, Kabanov AV (2006) Block ionomer complexes as prospective nanocontainers for drug delivery. J Control Release 115:9–17
Pardridge W (1999) Vector-mediated drug delivery to the brain. Adv Drug Deliv Rev 36:299–321
Pulskamp K, Diabate S, Krug HF (2007) Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 168:58–74
Raja P, Connolley J, Ganesan GP, Ci L, Ajayan PM, Nalamasu O, Thompson DM (2007) Impact of carbon nanotube exposure, dosage and aggregation on smooth muscle cells. Toxicol Lett 169:51–63
Richardson-Burns S, Hendricks JL, Foster B, Povlich LK, Kim DH, Martin DC (2007) Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells. Biomaterials 28:1539–1552
Roy S, Zhang K, Roth T, Vinogradov S, Kao RS, Kabanov A (1999) Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides. Nat Biotechnol 17:476–479
Sayes C, Liang F, Hudson JL, Mendez J, Guo W, Beach JM, Moore VC, Doyle CD, West JL, Billups WE, Ausman KD, Colvin VL (2006) Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 161:135–142
Schubert D, Dargusch R, Raitano J, Chan SW (2006) Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem Biophys Res Commun 342:86–91
Shaw L, Korecka M, Clark CM, Lee VM, Trojanowski JQ (2007) Biomarkers of neurodegenertion for diagnosis and monitoring therapeutics. Nat Rev Drug Discov 6:295–303
Shi N, Zhang Y, Zhu C, Boado RJ, Pardridge WM (2001) Brain-specific expression of an exogenous gene after i.v. administration. Proc Natl Acad Sci USA 98:12754–12759
Silva GA (2005) Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system. Surg Neurol 63:301–306
Silva GA, Czeisler C, Niece KL, Beniash E, Harrington DA, Kessler JA, Stupp SI (2004) Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303:1352–1355
Simard AR, Rivest S (2004) Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. Faseb J 18:998–1000
Solomatin SV, Bronich TK, Kabanov VA, Eisenberg A, Kabanov AV (2003) Environmentally responsive nanoparticles from block ionomer complexes: effect of pH and ionic strength. Langmuir 19:8069–8076
Solomatin SV, Bronich TK, Eisenberg A, Kabanov VA, Kabanov AV (2004) Colloidal stability of aqueous dispersions of block ionomer complexes: effects of temperature and salt. Langmuir 20:2066–2068
Solomatin SV, Bronich TK, Eisenberg A, Kabanov VA, Kabanov AV (2007) Nanomaterials from ionic block copolymers and single-, double-, and triple-tail surfactants. Langmuir 23:2838–2842
Streit WJ, Walter SA, Pennell NA (1999) Reactive microgliosis. Prog Neurobiol 57:563–581
Svenson S, Tomalia DA (2005) Dendrimers in biomedical applications—reflections on the field. Adv Drug Deliv Rev 57:2106–2129
Tian Y, He Q, Cui Y, Li J (2006) Fabrication of protein nanotubes based on layer-by-layer assembly. Biomacromolecules 7:2539–2542
Torchilin VP (2002) PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv Drug Deliv Rev 54:235–252
Torchilin VP (2004) Targeted polymeric micelles for delivery of poorly soluble drugs. Cell Mol Life Sci 61:2549–2559
Tsai CJ, Zheng J, Aleman C, Nussinov R (2006) Structure by design: from single proteins and their building blocks to nanostructures. Trends Biotechnol 24:449–454
Vinogradov SV (2006) Colloidal microgels in drug delivery applications. Curr Pharm Des 12:4703–4712
Vinogradov SV, Bronich TK, Kabanov AV (2002) Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev 54:135–147
Vinogradov S, Batrakova EV, Kabanov AV (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjug Chem 15:50–60
Wang F, Bronich TK, Kabanov AV, Rauh RD, Roovers J (2005) Synthesis and evaluation of a star amphiphilic block copolymer from poly(epsilon-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier. Bioconjug Chem 16:397–405
Wu G, Barth RF, Yang W, Kawabata S, Zhang L, Green-Church K (2006) Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates. Mol Cancer Ther 5:52–59
Xiao R, Cho SI, Liu R, Lee SB (2007) Controlled electrochemical synthesis of conductive polymer nanotube structures. J Am Chem Soc 129:4483–4489
Yan X, He Q, Wang K, Duan L, Cui Y, Li J (2007) Transition of cationic dipeptide nanotubes into vesicles and oligonucleotide delivery. Angew Chem Int Ed Engl 46:2431–2434
Yang H, Kao WJ (2006) Dendrimers for pharmaceutical and biomedical applications. J Biomater Sci Polym Ed 17:3–19
Yang F, Murugan R, Ramakrishna S, Wang X, Ma YX, Wang S (2004) Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 25:1891–1900
Yang W, Barth RF, Wu G, Kawabata S, Sferra TJ, Bandyopadhyaya AK, Tjarks W, Ferketich AK, Moeschberger ML, Binns PJ, Riley KJ, Coderre JA, Ciesielski MJ, Fenstermaker RA, Wikstrand CJ (2006) Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4. Clin Cancer Res 12:3792–3802
Yuwono VM, Hartgerink JD (2007) Peptide amphiphile nanofibers template and catalyze silica nanotube formation. Langmuir 23:5033–5038
Zhang GD, Harada A, Nishiyama N, Jiang DL, Koyama H, Aida T, Kataoka K (2003) Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer. J Control Release 93:141–150
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This work was supported by the grants from the National Institutes of Health RO1 NS36229, RO1 NS051335, RO1 CA89225, and RO1 CA116591, the National Science Foundation DMR 0513699, and the US Department of Defense USAMRMC 06108004 (all to AVK). The paper has been conceived and developed by the authors during the Polymer Therapeutics course taught in Spring 2007 in the Pharmaceutical Sciences Graduate Program (PSGP) as part of the extension of this training program at the University of Nebraska Medical Center (course coordinators A. V. Kabanov and T. K. Bronich).
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Jamie L. Gilmore and Xiang Yi made equal contributions.
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Gilmore, J.L., Yi, X., Quan, L. et al. Novel Nanomaterials for Clinical Neuroscience. J Neuroimmune Pharmacol 3, 83–94 (2008). https://doi.org/10.1007/s11481-007-9099-6
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DOI: https://doi.org/10.1007/s11481-007-9099-6