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Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility

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Abstract

Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine (CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm2 blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China

    Li Chen, JingAn Li & ShaoKang Guan

  2. School of Life Science, Zhengzhou University, Zhengzhou, 450001, China

    JiaWei Chang, ShiBo Jin, Di Wu & HaoHao Yan

  3. National Center for International Research of Micro-nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province, Zhengzhou, 450001, China

    XiaoFeng Wang

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  1. Li Chen
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Correspondence to JingAn Li or ShaoKang Guan.

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Chen, L., Li, J., Chang, J. et al. Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility. Sci. China Technol. Sci. 61, 1228–1237 (2018). https://doi.org/10.1007/s11431-017-9190-2

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  • DOI: https://doi.org/10.1007/s11431-017-9190-2

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