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Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products

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Abstract

Natural products (NPs), including traditional Chinese medicine (TCM), have been long and widely used in the prevention and treatment of central nervous system (CNS) diseases by virtue of their abundant sources, diverse structures, and novel activities. In this review article, we intend to summarize and discuss the situation or status of the clinical employments or trials of the NPs and their derivatives with CNS activities. NPs that have been extensively studied in preclinical research in recent years are also included. The compounds presented in this review are classified according to their indications and followed by details such as natural sources, possible biological mechanisms, and development status, while a considerable proportion of them are found in TCM. In addition, some drug combinations with synergistic effects are also mentioned. According to their impressive therapeutic effects and novel chemical structures, NPs are not only effective therapeutic remedies in clinic, but also lead compounds for structural modification, which indicate that nature brings new avenues to the therapy of CNS diseases.

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Acknowledgements

This work was supported by Special Foundation of Chinese Academy of Sciences for strategic pilot technology (XDA12040105) and National Science Foundation for Young Scientists of China (81703338). The authors thank Dongye Shen for his contribution to English editing and polishing of this manuscript.

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  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

    Junchi Zhang, Yang He, Xiangrui Jiang, Hualiang Jiang & Jingshan Shen

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Junchi Zhang

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Zhang, J., He, Y., Jiang, X. et al. Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products. Sci. China Life Sci. 62, 1332–1367 (2019). https://doi.org/10.1007/s11427-019-9587-y

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