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Recent developments in regenerative ophthalmology

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Abstract

Regenerative medicine (RM) is one of the most promising disciplines for advancements in modern medicine, and regenerative ophthalmology (RO) is one of the most active fields of regenerative medicine. This review aims to provide an overview of regenerative ophthalmology, including the range of tools and materials being used, and to describe its application in ophthalmologic subspecialties, with the exception of surgical implantation of artificial tissues or organs (e.g., contact lens, artificial cornea, intraocular lens, artificial retina, and bionic eyes) due to space limitations. In addition, current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted.

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Acknowledgements

This work was supported by a grant from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16040201). The authors thank Mrs. Meiyuan Xing and Mr. Haifeng Tu for the development of literature search strategy and conducting the actual search. They also thank Dr. Yuxi Zheng, Dr. Hong Zhu, Dr. Mengyun Liu, Dr. Liyue Zhang, and Dr. Qianjie Yang (Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University) for their help in information gathering and useful discussion. The strong technical support from Mr. Tang-liang Jiang during the development of the manuscript is deeply appreciated.

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  1. Contributed equally to this work

Authors and Affiliations

  1. Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310027, China

    Ye Shen, Dongyu Guo, Yuan Sun, Nan Hong, Xiawei Wang, Chen Xie, Yuan Zhao, Qin He, Le Jin, Yingying Wen, Bo Jiang, Chenying Yu & Miaomiao Zhu

  2. Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, China

    Xinghuai Sun

  3. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China

    He Shen & Jianwu Dai

  4. Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China

    He Shen & Jianwu Dai

  5. Academic Department, Zhenjiang LeiYin Vision Regenerative Medicine Co., Ltd., Zhenjiang, 212001, China

    Feng Cai

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  1. Ye Shen
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  2. He Shen
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Correspondence to Jianwu Dai.

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Shen, Y., Shen, H., Guo, D. et al. Recent developments in regenerative ophthalmology. Sci. China Life Sci. 63, 1450–1490 (2020). https://doi.org/10.1007/s11427-019-1684-x

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