Skip to main content
SpringerLink
Log in

External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications

  • Reviews
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

DNA devices that can recognize molecular inputs and transform them into functional outputs in an autonomous manner have been actively pursued as versatile toolkits for controlled nanofabrication, molecular network regulation, biosensing and cellular function modulation. The introduction of external stimuli-responsive units not only ensures the programmability and functionality of DNA devices themselves, but also confers rapid, remote and reversible dynamic regulation capabilities. This facilitates on-demand activation and expands the application scope of dynamic DNA devices. Herein, an overview of recent advances in the construction of stimuli-responsive DNA devices that respond to different exogenous triggers, including physical stimuli (e.g., light, thermal, magnetic field, and electric field), chemical stimuli (e.g., supermolecules, pH, redox, and metal ions), and biological cues (e.g., protein, biomolecule, and nucleic acid), and their controllable nanofabrication and biomedical application have been provided. The current challenges and potential solutions of these externally responsive DNA devices for their future advancements in this emerging field are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aprahamian I. ACS Cent Sci, 2020, 6: 347–358

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Moulin E, Faour L, Carmona-Vargas CC, Giuseppone N. Adv Mater, 2020, 32: 1906036

    Article  CAS  Google Scholar 

  3. Liu S, Jiang Q, Zhao X, Zhao R, Wang Y, Wang Y, Liu J, Shang Y, Zhao S, Wu T, Zhang Y, Nie G, Ding B. Nat Mater, 2021, 20: 421–430

    Article  CAS  PubMed  Google Scholar 

  4. Yu G, Yung BC, Zhou Z, Mao Z, Chen X. ACS Nano, 2018, 12: 7–12

    Article  CAS  PubMed  Google Scholar 

  5. Sun X, Dong Y, Liu Y, Song N, Li F, Yang D. Sci China Chem, 2022, 65: 31–47

    Article  CAS  Google Scholar 

  6. Zhang DY, Seelig G. Nat Chem, 2011, 3: 103–113

    Article  CAS  PubMed  Google Scholar 

  7. Ramezani H, Dietz H. Nat Rev Genet, 2020, 21: 5–26

    Article  CAS  PubMed  Google Scholar 

  8. Wang F, Lu CH, Willner I. Chem Rev, 2014, 114: 2881–2941

    Article  CAS  PubMed  Google Scholar 

  9. De Fazio AF, Misatziou D, Baker YR, Muskens OL, Brown T, Kanaras AG. Chem Soc Rev, 2021, 50: 13410–13440

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang J, Li Z, Willner I. Angew Chem Int Ed, 2023, 62: e202215332

    Article  CAS  Google Scholar 

  11. Liu N, Liedl T. Chem Rev, 2018, 118: 3032–3053

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Liu X, Lu CH, Willner I. Acc Chem Res, 2014, 47: 1673–1680

    Article  CAS  PubMed  Google Scholar 

  13. Han D, Pal S, Liu Y, Yan H. Nat Nanotech, 2010, 5: 712–717

    Article  CAS  Google Scholar 

  14. Li R, Zhu Y, Gong X, Zhang Y, Hong C, Wan Y, Liu X, Wang F. J Am Chem Soc, 2023, 145: 2999–3007

    Article  CAS  PubMed  Google Scholar 

  15. Wei J, Yu M, Tan K, Shang J, He S, Xie C, Liu X, Wang F. Small, 2023, 19: 2207961

    Article  CAS  Google Scholar 

  16. Li X, Yao D, Zhou J, Zhou X, Sun X, Wei B, Li C, Zheng B, Liang H. Sci China Chem, 2020, 63: 92–98

    Article  CAS  Google Scholar 

  17. Wang H, He Y, Wei J, Wang H, Ma K, Zhou Y, Liu X, Zhou X, Wang F. Angew Chem Int Ed, 2022, 61: e202115489

    Article  CAS  Google Scholar 

  18. Wu Q, Yang L, Xie L, Shang J, He S, Liu J, Wang F. Small, 2022, 18: 2200983

    Article  CAS  Google Scholar 

  19. Dong P, Li R, He S, Zhang Q, Shang J, Jiang Y, Liu X, Wang F. Chem Sci, 2023, 14: 2159–2167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Mohapatra S, Lin CT, Feng XA, Basu A, Ha T. Chem Rev, 2020, 120: 36–78

    Article  CAS  PubMed  Google Scholar 

  21. Zhou B, Dong Y, Liu D. ACS Appl Bio Mater, 2021, 4: 2251–2261

    Article  CAS  PubMed  Google Scholar 

  22. Simmel FC, Yurke B, Singh HR. Chem Rev, 2019, 119: 6326–6369

    Article  CAS  PubMed  Google Scholar 

  23. Song T, Gopalkrishnan N, Eshra A, Garg S, Mokhtar R, Bui H, Chandran H, Reif J. ACS Nano, 2018, 12: 11689–11697

    Article  CAS  PubMed  Google Scholar 

  24. Olson X, Kotani S, Padilla JE, Hallstrom N, Goltry S, Lee J, Yurke B, Hughes WL, Graugnard E. ACS Synth Biol, 2017, 6: 84–93

    Article  CAS  PubMed  Google Scholar 

  25. Sun X, Wei B, Guo Y, Xiao S, Li X, Yao D, Yin X, Liu S, Liang H. J Am Chem Soc, 2018, 140: 9979–9985

    Article  CAS  PubMed  Google Scholar 

  26. Ang YS, Yung LYL. Nucl Acids Res, 2021, 49: 4258–4265

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Wu Q, Xu M, Shang J, He S, Liu X, Wang F. Adv Sens Res, 2023, 2: 2200102

    Article  Google Scholar 

  28. Wang X, Kim G, Chu JL, Song T, Yang Z, Guo W, Shao X, Oelze ML, Li KC, Lu Y. J Am Chem Soc, 2022, 144: 5812–5819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Chen S, Liu TL, Dong Y, Li J. ACS Nano, 2022, 16: 20922–20936

    Article  CAS  PubMed  Google Scholar 

  30. Farag N, Đordević M, Del Grosso E, Ricci F. Adv Mater, 2023, 35: 2211274

    Article  CAS  Google Scholar 

  31. Bollu A, Klöcker N, Špaček P, P. Weissenboeck F, Hüwel S, Rentmeister A. Angew Chem Int Ed, 2023, 62: e202209975

    Article  CAS  Google Scholar 

  32. Qiu L, Wu C, You M, Han D, Chen T, Zhu G, Jiang J, Yu R, Tan W. J Am Chem Soc, 2013, 135: 12952–12955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. O’Hagan MP, Duan Z, Huang F, Laps S, Dong J, Xia F, Willner I. Chem Rev, 2023, 123: 6839–6887

    Article  PubMed  PubMed Central  Google Scholar 

  34. Zhao J, Gao J, Xue W, Di Z, Xing H, Lu Y, Li L. Am Chem Soc, 2018, 140: 578–581

    Article  CAS  Google Scholar 

  35. Zhang Y, Chen W, Zhang Y, Zhang X, Liu Y, Ju H. Angew Chem Int Ed, 2020, 59: 21454–21459

    Article  CAS  Google Scholar 

  36. Zhao J, Di Z, Li L. Angew Chem Int Ed, 2022, 61: e202204277

    Article  CAS  Google Scholar 

  37. Yang Z, Loh KY, Chu YT, Feng R, Satyavolu NSR, Xiong M, Nakamata Huynh SM, Hwang K, Li L, Xing H, Zhang X, Chemla YR, Gruebele M, Lu Y. Am Chem Soc, 2018, 140: 17656–17665

    Article  CAS  Google Scholar 

  38. Gao R, Xu L, Hao C, Xu C, Kuang H. Angew Chem Int Ed, 2019, 58: 3913–3917

    Article  CAS  Google Scholar 

  39. Wang C, Liu X, Wulf V, Vázquez-González M, Fadeev M, Willner I. ACSNano, 2019, 13: 3424–3433

    CAS  Google Scholar 

  40. Wang W, Satyavolu NSR, Wu Z, Zhang JR, Zhu JJ, Lu Y. Angew Chem Int Ed, 2017, 56: 6798–6802

    Article  CAS  Google Scholar 

  41. Du Y, Wang Q, Shi L, Li T. Nano Lett, 2022, 22: 6328–6333

    Article  CAS  PubMed  Google Scholar 

  42. Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S. Nucl Acids Res, 2006, 34: 5402–5415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Wang LL, Wen Y, Li L, Yang X, Jia N, Li W, Meng J, Duan M, Sun X, Liu G. Biosens Bioelectron, 2018, 115: 91–96

    Article  CAS  PubMed  Google Scholar 

  44. Guo W, Lu CH, Qi XJ, Orbach R, Fadeev M, Yang HH, Willner I. Angew Chem Int Ed, 2014, 53: 10134–10138

    Article  CAS  Google Scholar 

  45. Saw EN, Blanc N, Kanokkanchana K, Tschulik K. Electrochim Acta, 2018, 282: 317–323

    Article  CAS  Google Scholar 

  46. Wu Y, Huang J, He H, Wang M, Yin G, Qi L, He X, Wang HH, Wang K. Nano Lett, 2023, 23: 1801–1809

    Article  CAS  PubMed  Google Scholar 

  47. Guo Y, Yao D, Zheng B, Sun X, Zhou X, Wei B, Xiao S, He M, Li C, Liang H. ACS Nano, 2020, 14: 8317–8327

    Article  CAS  PubMed  Google Scholar 

  48. Idili A, Vallée-Bélisle A, Ricci F. J Am Chem Soc, 2014, 136: 5836–5839

    Article  CAS  PubMed  Google Scholar 

  49. Lu S, Wang S, Zhao J, Sun J, Yang X. Sci China Chem, 2020, 63: 404–410

    Article  CAS  Google Scholar 

  50. Tang Q, Lai W, Wang P, Xiong X, Xiao M, Li L, Fan C, Pei H. Angew Chem Int Ed, 2021, 60: 15013–15019

    Article  CAS  Google Scholar 

  51. Wang C, Fischer A, Ehrlich A, Nahmias Y, Willner I. Chem Sci, 2020, 11: 4516–4524

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Fu W, Tang L, Wei G, Fang L, Zeng J, Zhan R, Liu X, Zuo H, Huang CZ, Mao C. Angew Chem Int Ed, 2019, 58: 16405–16410

    Article  CAS  Google Scholar 

  53. Thompson IAP, Zheng L, Eisenstein M, Soh HT. Nat Commun, 2020, 11: 2946

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Tan W, Donovan MJ, Jiang J. Chem Rev, 2013, 113: 2842–2862

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Krissanaprasit A, Key CM, Pontula S, LaBean TH. Chem Rev, 2021, 121: 13797–13868

    Article  CAS  PubMed  Google Scholar 

  56. Guo S, Lin J, Lin L, Xu W, Guo Y, Xu Z, Lu C, Shi X, Chen L, Yang H. Sci China Chem, 2023, 66: 1529–1536

    Article  CAS  Google Scholar 

  57. Xu X, Xiao L, Gu C, Shang J, Xiang Y. ACS Omega, 2021, 6: 13153–13160

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Zhou M, Liang X, Mochizuki T, Asanuma H. Angew Chem Int Ed, 2010, 49: 2167–2170

    Article  CAS  Google Scholar 

  59. Trinh T, Thompson IAP, Clark F, Remington JM, Eisenstein M, Li J, Soh HT. ACSNano, 2022, 16: 14549–14557

    CAS  Google Scholar 

  60. You M, Chen Y, Zhang X, Liu H, Wang R, Wang K, Williams KR, Tan W. Angew Chem Int Ed, 2012, 51: 2457–2460

    Article  CAS  Google Scholar 

  61. Li L, Tong R, Chu H, Wang W, Langer R, Kohane DS. Proc Natl Acad Sci USA, 2014, 111: 17099–17103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Knutson SD, Sanford AA, Swenson CS, Korn MM, Manuel BA, Heemstra JM. J Am Chem Soc, 2020, 142: 17766–17781

    Article  CAS  PubMed  Google Scholar 

  63. Li S, Jiang Q, Liu Y, Wang W, Yu W, Wang F, Liu X. Anal Chem, 2021, 93: 11275–11283

    Article  CAS  PubMed  Google Scholar 

  64. Li XQ, Luo D, Song J, Jia YL, Song J, Chen HY, Xu JJ. Chem Commun, 2022, 58: 8210–8213

    Article  CAS  Google Scholar 

  65. Huo S, Zhou Y, Liao Z, Zhao P, Zou M, Göstl R, Herrmann A. Chem Commun, 2021, 57: 7438–7440

    Article  CAS  Google Scholar 

  66. Bakshi SF, Guz N, Zakharchenko A, Deng H, Tumanov AV, Woodworth CD, Minko S, Kolpashchikov DM, Katz E. J Am Chem Soc, 2017, 139: 12117–12120

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Bakshi SF, Guz N, Zakharchenko A, Deng H, Tumanov AV, Woodworth CD, Minko S, Kolpashchikov DM, Katz E. Nanoscale, 2018, 10: 1356–1365

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Li W, Wang H, Yang S, Isak AN, Song Y, Zhang F, Mao D, Zhu X. Anal Chem, 2022, 94: 2827–2834

    Article  CAS  PubMed  Google Scholar 

  69. Tang J, Yao C, Gu Z, Jung S, Luo D, Yang D. Angew Chem Int Ed, 2020, 59: 2490–2495

    Article  CAS  Google Scholar 

  70. Freage L, Trifonov A, Tel-Vered R, Golub E, Wang F, McCaskill JS, Willner I. Chem Sci, 2015, 6: 3544–3549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Wang W, Shen Y, Wang F, Liu Y, Liu X. Chem Commun, 2021, 57: 11205–11208

    Article  CAS  Google Scholar 

  72. Amodio A, Del Grosso E, Troina A, Placidi E, Ricci F. Nano Lett, 2018, 18: 2918–2923

    Article  CAS  PubMed  Google Scholar 

  73. Zhang Y, Li Q, Guo L, Huang Q, Shi J, Yang Y, Liu D, Fan C. Angew Chem Int Ed, 2016, 55: 12450–12454

    Article  CAS  Google Scholar 

  74. Shao Y, Zhao J, Yuan J, Zhao Y, Li L. Angew Chem IntEd, 2021, 60: 8923–8931

    Article  CAS  Google Scholar 

  75. Korman A, Sun H, Hua B, Yang H, Capilato JN, Paul R, Panja S, Ha T, Greenberg MM, Woodson SA. Proc Natl Acad Sci USA, 2020, 117: 12080–12086

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Torabi SF, Wu P, McGhee CE, Chen L, Hwang K, Zheng N, Cheng J, Lu Y. Proc Natl Acad Sci USA, 2015, 112: 5903–5908

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Hwang K, Wu P, Kim T, Lei L, Tian S, Wang Y, Lu Y. Angew Chem IntEd, 2014, 53: 13798–13802

    Article  CAS  Google Scholar 

  78. Wang J, Yue L, Li Z, Zhang J, Tian H, Willner I. Nat Commun, 2019, 10: 4963

    Article  PubMed  PubMed Central  Google Scholar 

  79. Valero J, Centola M, Ma Y, Š kugor M, Yu Z, Haydell MW, Keppner D, Famulok M. Nat Protoc, 2019, 14: 2818–2855

    Article  CAS  PubMed  Google Scholar 

  80. Zhu J, Lin H, Kim Y, Yang M, Skakuj K, Du JS, Lee B, Schatz GC, Van Duyne RP, Mirkin CA. Adv Mater, 2020, 32: 1906600

    Article  CAS  Google Scholar 

  81. O’Hagan MP, Haldar S, Duchi M, Oliver TAA, Mulholland AJ, Morales JC, Galan MC. Angew Chem Int Ed, 2019, 58: 4334–4338

    Article  Google Scholar 

  82. Zhang J, Zhao P, Li W, Ye L, Li L, Li Z, Li M. Angew Chem Int Ed, 2022, 61: e202117562

    Article  CAS  Google Scholar 

  83. Shang J, Yu S, Li R, He Y, Wang Y, Wang F. Nano Lett, 2023, 23: 1386–1394

    Article  CAS  PubMed  Google Scholar 

  84. Zhao Y, Li R, Sun J, Zou Z, Wang F, Liu X. ACS Nano, 2022, 16: 5404–5417

    Article  CAS  PubMed  Google Scholar 

  85. Wu Z, Fan H, Satyavolu NSR, Wang WJ, Lake R, Jiang JH, Lu Y. Angew Chem Int Ed, 2017, 56: 8721–8725

    Article  CAS  Google Scholar 

  86. Chu H, Zhao J, Mi Y, Zhao Y, Li L. Angew Chem Int Ed, 2019, 58: 14877–14881

    Article  CAS  Google Scholar 

  87. Zhang Y, Chen J, Yang H, Yin W, Li C, Xu Y, Liu SY, Dai Z, Zou X. Anal Chem, 2022, 94: 9665–9673

    Article  CAS  PubMed  Google Scholar 

  88. Zhao X, Zhang L, Gao W, Yu X, Gu W, Fu W, Luo Y. ACS Appl Mater Interfaces, 2020, 12: 35958–35966

    Article  CAS  PubMed  Google Scholar 

  89. Ye M, Kong Y, Zhang C, Lv Y, Cheng S, Hou D, Xian Y. ACS Nano, 2021, 15: 14253–14262

    Article  CAS  PubMed  Google Scholar 

  90. Skugor M, Valero J, Murayama K, Centola M, Asanuma H, Famulok M. Angew Chem Int Ed, 2019, 58: 6948–6951

    Article  CAS  Google Scholar 

  91. Wang S, Yue L, Li Z-, Zhang J, Tian H, Willner I. Angew Chem Int Ed, 2018, 57: 8105–8109

    Article  CAS  Google Scholar 

  92. Ranallo S, Amodio A, Idili A, Porchetta A, Ricci F. Chem Sci, 2016, 7: 66–71

    Article  CAS  PubMed  Google Scholar 

  93. Zhai T, Sun C, Ye D, Xia K, Liu X, Fan C, Li Q, Shen J. J Electroanal Chem, 2022, 905: 115901

    Article  CAS  Google Scholar 

  94. Xiao L, Wang LL, Wu CQ, Li H, Zhang QL, Wang Y, Xu L. Nat Commun, 2022, 13: 5936

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Tian T, Song Y, Wei L, Wang J, Fu B, He Z, Yang XR, Wu F, Xu G, Liu SM, Li C, Wang S, Zhou X. Nucl Acids Res, 2017, 45: gkx025

    Article  Google Scholar 

  96. Zhou X, Su X, Pathak P, Vik R, Vinciguerra B, Isaacs L, Jaya-wickramarajah J. J Am Chem Soc, 2017, 139: 13916–13921

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Kankanamalage DVDW, Tran JHT, Beltrami N, Meng K, Zhou X, Pathak P, Isaacs L, Burin AL, Ali MF, Jayawickramarajah J. J Am Chem Soc, 2022, 144: 16502–16511

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Hu Y, Ying JY. Small, 2023, 19: 2205909

    Article  CAS  Google Scholar 

  99. Yao D, Bhadra S, Xiong E, Liang H, Ellington AD, Jung C. ACS Nano, 2020, 14: 4007–4013

    Article  CAS  PubMed  Google Scholar 

  100. Hu Y, Gao S, Lu H, Ying JY. J Am Chem Soc, 2022, 144: 5461–5470

    Article  CAS  PubMed  Google Scholar 

  101. Naskar S, Guha R, Miiller J. Angew Chem Int Ed, 2020, 59: 1397–1406

    Article  CAS  Google Scholar 

  102. Fischer A, Lilienthal S, Vazquez-Gonzalez M, Fadeev M, Sohn YS, Nechushtai R, Willner I. J Am Chem Soc, 2020, 142: 4223–4234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Ono A, Togashi H. Angew Chem Int Ed, 2004, 43: 4300–4302

    Article  CAS  Google Scholar 

  104. Vecchioni S, Lu B, Livernois W, Ohayon YP, Yoder JB, Yang C-, Woloszyn K, Bernfeld W, Anantram MP, Canary JW, Hendrickson WA, Rothschild LJ, Mao C, Wind SJ, Seeman NC, Sha R. Adv Mater, 2023, 35: 2210938

    Article  CAS  Google Scholar 

  105. Del Grosso E, Ponzo I, Ragazzon G, Prins LJ, Ricci F. Angew Chem IntEd, 2020, 59: 21058–21063

    Article  CAS  Google Scholar 

  106. Higashi SL, Isogami A, Takahashi J, Shibata A, Hirosawa KM, Suzuki KGN, Sawada S, Tsukiji S, Matsuura K, Ikeda M. Chem —An Asian J, 2022, 17: 2200142

    Article  Google Scholar 

  107. Takezawa Y, Nakama T, Shionoya M. J Am Chem Soc, 2019, 141: 19342–19350

    Article  CAS  PubMed  Google Scholar 

  108. Wang Q, Wang Z, He Y, Xiong B, Li Y, Wang F. TrAC Trends Anal Chem, 2023, 159: 116910

    Article  CAS  Google Scholar 

  109. Qian RC, Zhou ZR, Guo W, Wu Y, Yang Z, Lu Y. J Am Chem Soc, 2021, 143: 5737–5744

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Yang Q, Deng Z, Wang D, He J, Zhang D, Tan Y, Peng T, Wang XQ, Tan W. J Am Chem Soc, 2020, 142: 2532–2540

    Article  CAS  PubMed  Google Scholar 

  111. Biniuri Y, Luo GF, Fadeev M, Wulf V, Willner I. J Am Chem Soc, 2019, 141: 15567–15576

    Article  CAS  PubMed  Google Scholar 

  112. Xiao L, Gu C, Xiang Y. Angew Chem IntEd, 2019, 58: 14167–14172

    Article  CAS  Google Scholar 

  113. Wang Q, Tan K, Wang H, Shang J, Wan Y, Liu X, Weng X, Wang F. J Am Chem Soc, 2021, 143: 6895–6904

    Article  CAS  PubMed  Google Scholar 

  114. Ranallo S, Sorrentino D, Delibato E, Ercolani G, Plaxco KW, Ricci F. Angew Chem Int Ed, 2022, 61: e202115680

    Article  CAS  Google Scholar 

  115. Bertucci A, Porchetta A, Del Grosso E, Patiño T, Idili A, Ricci F. Angew Chem Int Ed, 2020, 59: 20577–20581

    Article  CAS  Google Scholar 

  116. Wang Z, Xie S, Wu L, Chen F, Qiu L, Tan W. Nano Lett, 2022, 22: 7853–7859

    Article  CAS  PubMed  Google Scholar 

  117. Centola M, Valero J, Famulok M. J Am Chem Soc, 2017, 139: 16044–16047

    Article  CAS  PubMed  Google Scholar 

  118. Dong J, Ouyang Y, Wang J, O’Hagan MP, Willner I. ACS Nano, 2022, 16: 6153–6164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Hu Y, Wang Z, Chen Z, Pan L. Nucl Acids Res, 2020, 48: 8591–8600

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Yue L, Wang S, Lilienthal S, Wulf V, Remacle F, Levine RD, Willner I. J Am Chem Soc, 2018, 140: 8721–8731

    Article  CAS  PubMed  Google Scholar 

  121. Zhang QL, Wang LL, Liu Y, Lin J, Xu L. Nat Commun, 2021, 12: 4654

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Yue L, Wang S, Willner I. Sci Adv, 2019, 5: eaav5564

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Yue L, Wang S, Wulf V, Willner I. Nat Commun, 2019, 10: 4774

    Article  PubMed  PubMed Central  Google Scholar 

  124. Zhang P, Yue L, Vazquez-Gonzalez M, Zhou Z, Chen WH, Sohn YS, Nechushtai R, Willner I. ACS Nano, 2020, 14: 1482–1491

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (22104116, 22209045, 22274121, 22274123) and the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University (ZNJC202231).

Author information

Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

    Wei Xu, Jinhua Shang, Xiaoqing Liu & Fuan Wang

  2. School of Medicine, Wuhan University of Science and Technology, Wuhan, 430081, China

    Feifei Hu, Jiajing Li, Yan Zeng & Qiong Wu

  3. College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Wei Xu

Authors
  1. Wei Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Feifei Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jiajing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jinhua Shang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaoqing Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yan Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Qiong Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Fuan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yan Zeng, Qiong Wu or Fuan Wang.

Ethics declarations

Conflict of interest The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, W., Hu, F., Li, J. et al. External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications. Sci. China Chem. 66, 3105–3115 (2023). https://doi.org/10.1007/s11426-023-1783-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-023-1783-5

Search

Navigation