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Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes

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Abstract

The use of simple and easily available feedstock to quickly and efficiently obtain compounds with complex molecular structures through the transition-metal-catalyzed construction of C(sp3)-C bonds has important significance. As traditional C(sp3)-C coupling reagents, alkylmetallic reagents often have limitations such as air and moisture sensitivity and difficulties in storage. Nickel-catalyzed reductive olefin hydrocarbonation reactions use alkenes to replace organometallic reagents, reduce the synthesis steps, improve the functional group compatibility, and expand the substrate scope This minireview discusses important progress in the hydroalkylation and hydroarylation of electronically unbiased alkenes in recent years and describes the key mechanism and applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21732006, 21702200, 51821006, 51961135104) and the Fundamental Research Funds for the Central Universities.

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  1. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, iChEM, University of Science and Technology of China, Hefei, 230026, China

    Xiao-Xu Wang, Xi Lu, Yan Li, Jia-Wang Wang & Yao Fu

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  1. Xiao-Xu Wang
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Correspondence to Xi Lu or Yao Fu.

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Wang, XX., Lu, X., Li, Y. et al. Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes. Sci. China Chem. 63, 1586–1600 (2020). https://doi.org/10.1007/s11426-020-9838-x

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