Skip to main content
SpringerLink
Log in

Nanoelectrochemical architectures for high-spatial-resolution single cell analysis

  • Reviews
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

The analysis of single cells instead of cell populations is important for characterizing cellular heterogeneity and elucidating the cellular signalling pathways. Nanoelectrodes have emerged as an increasingly important tool for biomolecule analyses at the single-cell level with high spatial or temporal resolution. Various electrochemical methods, such as amperometry and scanning electrochemical microscopy (SECM), have been applied. Research to date has focused on the development of new nanoelectrochemical architectures, such as arrays, to achieve higher spatial resolution and faster analysis rates for single-cell analysis. In this review, the fabrication of these new nanoelectrochemical architectures and their applications in high spatial resolution single-cell analyses are discussed. The recent progress of Chinese researchers is highlighted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Davey HM, Kell DB. Microbiol Rev, 1996, 60: 641–696

    CAS  Google Scholar 

  2. Kovarik ML, Allbritton NL. Trends Biotech, 2011, 29: 222–230

    Article  CAS  Google Scholar 

  3. Wang DJ, Bodovitz S. Trends Biotechnol, 2011, 28: 281–290

    Article  Google Scholar 

  4. Colman-Lerner A, Gordon A, Serra E, Chin T, Resnekov O, Endy D, Gustavo Pesce C, Brent R. Nature, 2005, 437: 699–706

    Article  CAS  Google Scholar 

  5. Brown RB, Hewel JA, Emili A, Audet J. Cytometry, 2010, 77A: 347–355

    Google Scholar 

  6. Ferrell Jr JE, Machleder EM. Science, 1998, 280: 895–898

    Article  CAS  Google Scholar 

  7. Oh-Hora M. Immunol Rev, 2009, 231: 210–224

    Article  CAS  Google Scholar 

  8. Shoemaker GK, Lorieau J, Lau LH, Gillmor CS, Palcic MM. Anal Chem, 2005, 77: 3132–3137

    Article  CAS  Google Scholar 

  9. Toriello NM, Douglas ES, Thaitrong N, Hsiao SC, Francis MB, Bertozzi CR, Mathies RA. Proc Natl Acad Sci USA, 2008, 105: 20173–20178

    Article  CAS  Google Scholar 

  10. Wang L, Duan E, Sung L, Jeong BS, Yang X, Tian XC. Biol Reprod, 2005, 73: 149–155

    Article  CAS  Google Scholar 

  11. Hatoya S, Torii R, Kondo Y, Okuno T, Kobayashi K, Wijewardana V, Kawate N, Tamada H, Sawada T, Kumagai D, Sugiura K, Inaba T. Mol Reprod Dev, 2006, 73: 298–305

    Article  CAS  Google Scholar 

  12. Adams KL, Puchades M, Ewing AG. Annu Rev Anal Chem, 2008, 1: 329–355

    Article  CAS  Google Scholar 

  13. Forster RJ. Chem Soc Rev, 1994, 23: 289–297

    Article  CAS  Google Scholar 

  14. Amatore C, Arbault S, Guille M, Lemâitre F. Chem Rev, 2008, 108: 2585–2621

    Article  CAS  Google Scholar 

  15. Sulzer D, Pothos EN. Rev Neurosci, 2000, 11: 159–212

    Article  CAS  Google Scholar 

  16. Adams RN. Anal Chem, 1976, 48: 1126A–1138A

    Article  CAS  Google Scholar 

  17. Leszczyszyn DJ, Jankowski JA, Viveros OH, Diliberto EJ, Near JA, Wightman RM. J Biol Chem, 1990, 265: 14736–14737

    CAS  Google Scholar 

  18. Wightman RM. Science, 2006, 311: 1570–1574

    Article  CAS  Google Scholar 

  19. Amemiya S, Bard AJ, Fan FRF, Mirkin MV, Unwin PR. Annu Rev Anal Chem, 2008, 1: 95–131

    Article  CAS  Google Scholar 

  20. Bard AJ, Li X, Zhan W. Biosens Bioelectron, 2006, 22: 461–472

    Article  CAS  Google Scholar 

  21. Schulte A, Nebel M, Schuhmann W. Annu Rev Anal Chem, 2010, 3: 299–318

    Article  CAS  Google Scholar 

  22. Murray RW. Chem Rev, 2008, 108: 2688–2720

    Article  CAS  Google Scholar 

  23. Bard AJ. ACS Nano, 2008, 2: 2437–2440

    Article  CAS  Google Scholar 

  24. Penner RM, Heben MJ, Longin TL, Lewis NS. Science, 1990, 250: 1118–1121

    Article  CAS  Google Scholar 

  25. Shao Y, Mirkin MV, Fish G, Kokotov S, Palanker D, Lewis A. Anal Chem, 1997, 69: 1627–1634

    Article  CAS  Google Scholar 

  26. Campbell JK, Sun L, Crooks RM. J Am Chem Soc, 1999, 121: 3779–3780

    Article  CAS  Google Scholar 

  27. Bach CE. J Electrochem Soc, 1993, 140: 1281–1284

    Article  CAS  Google Scholar 

  28. Li Y, Bergman D, Zhang B. Anal Chem, 2009, 81: 5496–5502

    Article  CAS  Google Scholar 

  29. Pan R, Xu M, Jiang D, Burgess JD, Chen HY. Proc Natl Acad Sci USA, 2016, 113: 11436–11440

    Article  CAS  Google Scholar 

  30. Ji T, Liang Z, Zhu X, Wang L, Liu S, Shao Y. Chem Sci, 2011, 2: 1523–1529

    Article  CAS  Google Scholar 

  31. Sun P, Zhang Z, Guo J, Shao Y. Anal Chem, 2001, 73: 5346–5351

    Article  CAS  Google Scholar 

  32. Moran CE, Radloff C, Halas NJ. Adv Mater, 2003, 15: 804–807

    Article  CAS  Google Scholar 

  33. Dai X, Wildgoose GG, Salter C, Crossley A, Compton RG. Anal Chem, 2006, 78: 6102–6108

    Article  CAS  Google Scholar 

  34. Kong Y, Chen H, Wang Y, Soper SA. Electrophoresis, 2006, 27: 2940–2950

    Article  CAS  Google Scholar 

  35. Zhang Q, Xu JJ, Liu Y, Chen HY. Lab Chip, 2008, 8: 352–357

    Article  CAS  Google Scholar 

  36. Strein TG, Ewing AG. Anal Chem, 1992, 64: 1368–1373

    Article  CAS  Google Scholar 

  37. Huang WH, Pang DW, Tong H, Wang ZL, Cheng JK. Anal Chem, 2001, 73: 1048–1052

    Article  CAS  Google Scholar 

  38. Wu WZ, Huang WH, Wang W, Wang ZL, Cheng JK, Xu T, Zhang RY, Chen Y, Liu J. J Am Chem Soc, 2005, 127: 8914–8915

    Article  CAS  Google Scholar 

  39. Finkel T. Curr Opin Cell Biol, 2003, 15: 247–254

    Article  CAS  Google Scholar 

  40. Houstis N, Rosen ED, Lander ES. Nature, 2006, 440: 944–948

    Article  CAS  Google Scholar 

  41. Adler V, Yin Z, Tew KD, Ronai Z. Oncogene, 1999, 18: 6104–6111

    Article  CAS  Google Scholar 

  42. Zhang X, Wang J, Ogorevc B, Spichiger UE. Electroanalysis, 1999, 11: 945–949

    Article  CAS  Google Scholar 

  43. Lapierre-Devlin MA, Asher CL, Taft BJ, Gasparac R, Roberts MA, Kelley SO. Nano Lett, 2005, 5: 1051–1055

    Article  CAS  Google Scholar 

  44. Delvaux M, Demoustier-Champagne S, Walcarius A. Electroanalysis, 2004, 16: 190–198

    Article  CAS  Google Scholar 

  45. Ma C, Contento NM, GibsonII LR, Bohn PW. ACS Nano, 2013, 7: 5483–5490

    Article  CAS  Google Scholar 

  46. Zhuang L, Zuo H, Wu Z, Wang Y, Fang D, Jiang D. Anal Chem, 2014, 86: 11517–11522

    Article  CAS  Google Scholar 

  47. Li YT, Zhang SH, Wang L, Xiao RR, Liu W, Zhang XW, Zhou Z, Amatore C, Huang WH. Angew Chem Int Ed, 2014, 53: 12456–12460

    CAS  Google Scholar 

  48. Li YT, Zhang SH, Wang XY, Zhang XW, Oleinick AI, Svir I, Amatore C, Huang WH. Angew Chem Int Ed, 2015, 54: 9313–9318

    Article  CAS  Google Scholar 

  49. Sun P, Laforge FO, Abeyweera TP, Rotenberg SA, Carpino J, Mirkin MV. Proc Natl Acad Sci USA, 2008, 105: 443–448

    Article  CAS  Google Scholar 

  50. Wang Y, Noël JM, Velmurugan J, Nogala W, Mirkin MV, Lu C, Guille Collignon M, Lemaître F, Amatore C. Proc Natl Acad Sci USA, 2012, 109: 11534–11539

    Article  CAS  Google Scholar 

  51. Li X, Majdi S, Dunevall J, Fathali H, Ewing AG. Angew Chem Int Ed, 2015, 54: 11978–11982

    Article  CAS  Google Scholar 

  52. Zhang Y, Li M, Li Z, Li Q, Aldalbahi A, Shi J, Wang L, Fan C, Zuo X. Sci China Chem, 2017, 53: doi: 10.1007/s11426-017-9036-0

    Google Scholar 

  53. Cheung KC. Biomed Microdevices, 2007, 9: 923–938

    Article  Google Scholar 

  54. Taketani M, Baudry M. Advances in Network Electrophysiology. US: Springer, 2006

    Book  Google Scholar 

  55. Ito T, Okazaki S. Nature, 2000, 406: 1027–1031

    Article  CAS  Google Scholar 

  56. Huang XJ, O’Mahony AM, Compton RG. Small, 2009, 5: 776–788

    Article  CAS  Google Scholar 

  57. Sandison ME, Cooper JM. Lab Chip, 2006, 6: 1020–1025

    Article  CAS  Google Scholar 

  58. Jiang X, Hu J, Fitzgerald LA, Biffinger JC, Xie P, Ringeisen BR, Lieber CM. Proc Natl Acad Sci USA, 2010, 107: 16806–16810

    Article  CAS  Google Scholar 

  59. Qiu W, Xu M, Li R, Liu X, Zhang M. Anal Chem, 2016, 88: 1117–1122

    Article  CAS  Google Scholar 

  60. Tu Y, Lin Y, Ren ZF. Nano Lett, 2003, 3: 107–109

    Article  CAS  Google Scholar 

  61. Patolsky F, Zheng G, Lieber CM. Anal Chem, 2006, 78: 4260–4269

    Article  CAS  Google Scholar 

  62. Liu X, Barizuddin S, Shin W, Mathai CJ, Gangopadhyay S, Gillis KD. Anal Chem, 2011, 83: 2445–2451

    Article  CAS  Google Scholar 

  63. Rettig JR, Folch A. Anal Chem, 2005, 77: 5628–5634

    Article  CAS  Google Scholar 

  64. Xu Y, Yao H, Wang L, Xing W, Cheng J. Lab Chip, 2011, 11: 2417

    Article  CAS  Google Scholar 

  65. Lin Z, Takahashi Y, Kitagawa Y, Umemura T, Shiku H, Matsue T. Anal Chem, 2008, 80: 6830–6833

    Article  CAS  Google Scholar 

  66. Lin Z, Takahashi Y, Murata T, Takeda M, Ino K, Shiku H, Matsue T. Angew Chem Int Ed, 2009, 48: 2044–2046

    Article  CAS  Google Scholar 

  67. Hafez I, Kisler K, Berberian K, Dernick G, Valero V, Yong MG, Craighead HG, Lindau M. Proc Natl Acad Sci USA, 2005, 102: 13879–13884

    Article  CAS  Google Scholar 

  68. Xie C, Lin Z, Hanson L, Cui Y, Cui B. Nat Nanotech, 2012, 7: 185–190

    Article  CAS  Google Scholar 

  69. Lin ZC, Xie C, Osakada Y, Cui Y, Cui B. Nat Commun, 2014, 5: 3206

    Google Scholar 

  70. Laborde C, Pittino F, Verhoeven HA, Lemay SG, Selmi L, Jongsma MA, Widdershoven FP. Nat Nanotech, 2015, 10: 791–795

    Article  CAS  Google Scholar 

  71. Patolsky F, Timko BP, Yu G, Fang Y, Greytak AB, Zheng G, Lieber CM. Science, 2006, 313: 1100–1104

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (21327902).

Author information

Authors and Affiliations

  1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China

    Junyu Zhou, Dechen Jiang & Hong-Yuan Chen

Authors
  1. Junyu Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dechen Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hong-Yuan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dechen Jiang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, J., Jiang, D. & Chen, HY. Nanoelectrochemical architectures for high-spatial-resolution single cell analysis. Sci. China Chem. 60, 1277–1284 (2017). https://doi.org/10.1007/s11426-017-9109-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-017-9109-7

Keywords

Search

Navigation