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Analytical methods for nano-bio interface interactions

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Abstract

Knowledge on the interactions between engineered nanomaterials (ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

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Authors and Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China

    Jing Wang, Waseem Akthar Quershi, Yiye Li, Jianxun Xu & Guangjun Nie

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  1. Jing Wang
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  2. Waseem Akthar Quershi
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  3. Yiye Li
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  4. Jianxun Xu
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Correspondence to Guangjun Nie.

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Wang, J., Quershi, W.A., Li, Y. et al. Analytical methods for nano-bio interface interactions. Sci. China Chem. 59, 1467–1478 (2016). https://doi.org/10.1007/s11426-016-0340-1

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