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Nanoparticulate X-ray CT contrast agents

  • Mini Reviews
  • Special Topic Analytical Sciences at the Nano-Bio Interface
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Abstract

X-ray computed tomography (CT) has been widely used as a powerful diagnostic tool in clinics because it can provide high-resolution 3D tomography of the anatomic structure based on the distinctive X-ray absorptions between different tissues. Currently, CT contrast agents are mainly small iodinated molecules, which suffer from drawbacks such as short bloodretention time, nonspecific in vivo biodistribution, and renal toxicity. Utilization of nanoparticles as potential CT contrast agents to overcome the aforementioned issues has advanced rapidly. In this mini review, we introduce current research efforts in the development of nanoparticulate CT contrast agents and discuss the challenges for additional breakthroughs in this field.

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Authors and Affiliations

  1. State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Wenya He, Kelong Ai & Lehui Lu

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  1. Wenya He
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  2. Kelong Ai
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  3. Lehui Lu
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Correspondence to Kelong Ai.

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He, W., Ai, K. & Lu, L. Nanoparticulate X-ray CT contrast agents. Sci. China Chem. 58, 753–760 (2015). https://doi.org/10.1007/s11426-015-5351-8

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  • DOI: https://doi.org/10.1007/s11426-015-5351-8

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