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Effect of glutathione on in vivo biodistribution and clearance of surface-modified small Pd nanosheets

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Abstract

Plasmonic Pd nanosheets have been emerging as promising materials for applying in near-infrared (NIR) photothermal therapy (PTT) of cancer. However, animal in mice studies indicated that the original synthesized poly(vinylpyrrolidone) (PVP)-protected small Pd nanosheets (Pd-PVP) and some further surface-modified small Pd nanosheets such as Pd-PEG(SH) easily accumulated in reticuloendothelial system (RES) organs (liver, spleen, etc.) and were difficult to be cleared from these organs quickly. In the work, we surprisingly found that glutathione (GSH) could promote the clearance of surface-modified small Pd nanosheets (e.g. Pd-PVP, Pd-PEG(SH) and Pd-GSH) from the RES organs efficiently. The effects of GSH on the biodistribution and clearance of different surface-modified Pd nanosheets were investigated. Our results indicated that these surface-modified Pd nanosheets with or without GSH added caused no morbidity at target primary organs, and GSH can promote the clearance of different surface-modified Pd nanosheets in the order of Pd-PVP≈Pd-PEG(SH)>Pd-GSH. This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems (RES).

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Authors and Affiliations

  1. State Key Laboratory for Physical Chemistry of Solid Surfaces; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China

    Yizhuan Huang, Xiaolan Chen, Saige Shi, Mei Chen, Shaoheng Tang, Shiguang Mo, Jingping Wei & Nanfeng Zheng

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  1. Yizhuan Huang
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  2. Xiaolan Chen
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  3. Saige Shi
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  4. Mei Chen
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  5. Shaoheng Tang
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  6. Shiguang Mo
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  7. Jingping Wei
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  8. Nanfeng Zheng
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Correspondence to Xiaolan Chen or Nanfeng Zheng.

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Huang, Y., Chen, X., Shi, S. et al. Effect of glutathione on in vivo biodistribution and clearance of surface-modified small Pd nanosheets. Sci. China Chem. 58, 1753–1758 (2015). https://doi.org/10.1007/s11426-015-5422-x

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  • DOI: https://doi.org/10.1007/s11426-015-5422-x

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