Ross R, Blair SN, Arena R, Church TS, Despres JP, Franklin BA, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation. 2016;134(24):e653–99.
Lee DC, Sui X, Church TS, Lavie CJ, Jackson AS, Blair SN. Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. J Am Coll Cardiol. 2012;59(7):665–72.
Fogelholm M. Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev. 2010;11(3):202–21.
Barry VW, Baruth M, Beets MW, Durstine JL, Liu J, Blair SN. Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis. 2014;56(4):382–90.
Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2015;4(7). https://doi.org/10.1161/JAHA.115.002014.
Harber MP, Kaminsky LA, Arena R, Blair SN, Franklin BA, Myers J, et al. Impact of cardiorespiratory fitness on all-cause and disease-specific mortality: advances since 2009. Prog Cardiovasc Dis. 2017;60(1):11–20.
Bouchard C, Blair SN, Katzmarzyk PT. Less sitting, more physical activity, or higher fitness? Mayo Clin Proc. 2015 Nov;90(11):1533–40.
Coffman KE, Carlson AR, Miller AD, Johnson BD, Taylor BJ. The effect of aging and cardiorespiratory fitness on the lung diffusing capacity response to exercise in healthy humans. J Appl Physiol (1985). 2017;122(6):1425–34.
Beaufrere B, Morio B. Fat and protein redistribution with aging: metabolic considerations. Eur J Clin Nutr. 2000;54(Suppl 3):S48–53.
Floegel A, Wientzek A, Bachlechner U, Jacobs S, Drogan D, Prehn C, et al. Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study. Int J Obes. 2014;38(11):1388–96.
Bouchard DR, McGuire KA, Davidson L, Ross R. Cardiorespiratory fitness, obesity, and functional limitation in older adults. J Aging Phys Act. 2011;19(4):336–46.
Koch LG, Britton SL. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics. 2001;5(1):45–52.
Koch LG, Britton SL, Wisloff U. A rat model system to study complex disease risks, fitness, aging, and longevity. Trends Cardiovasc Med. 2012;22(2):29–34.
Wisloff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, et al. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science. 2005;307(5708):418–20.
Koch LG, Kemi OJ, Qi N, Leng SX, Bijma P, Gilligan LJ, et al. Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res. 2011;109(10):1162–72.
Falegan OS, Vogel HJ, Hittel DS, Koch LG, Britton SL, Hepple RT, et al. High aerobic capacity mitigates changes in the plasma metabolomic profile associated with aging. J Proteome Res. 2017;16(2):798–805.
Overmyer KA, Evans CR, Qi NR, Minogue CE, Carson JJ, Chermside-Scabbo CJ, et al. Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation. Cell Metab. 2015;21(3):468–78.
Karvinen SM, Silvennoinen M, Ma H, Tormakangas T, Rantalainen T, Rinnankoski-Tuikka R, et al. Voluntary running aids to maintain high body temperature in rats bred for high aerobic capacity. Front Physiol. 2016;7:311.
Heinonen S, Jokinen R, Rissanen A, Pietilainen KH. White adipose tissue mitochondrial metabolism in health and in obesity. Obes Rev. 2020;21(2):e12958.
Stanford KI, Goodyear LJ. Muscle-adipose tissue cross talk. Cold Spring Harb Perspect Med. 2018;8(8). https://doi.org/10.1101/cshperspect.a029801.
Wone B, Donovan ER, Hayes JP. Metabolomics of aerobic metabolism in mice selected for increased maximal metabolic rate. Comp Biochem Physiol D Genomics Proteomics. 2011;6(4):399–405.
Bowden-Davies K, Connolly J, Burghardt P, Koch LG, Britton SL, Burniston JG. Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity. Proteomics. 2015;15(13):2342–9.
Karvinen S, Silvennoinen M, Vainio P, Sistonen L, Koch LG, Britton SL, et al. Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. Exp Gerontol. 2016;79:46–54.
Kivela R, Silvennoinen M, Lehti M, Rinnankoski-Tuikka R, Purhonen T, Ketola T, et al. Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J. 2010;24(11):4565–74.
Nandania J, Peddinti G, Pessia A, Kokkonen M, Velagapudi V. Validation and automation of a high-throughput multitargeted method for semiquantification of endogenous metabolites from different biological matrices using tandem mass spectrometry. Metabolites. 2018;8(3). https://doi.org/10.3390/metabo8030044.
Lautaoja JH, Lalowski M, Nissinen TA, Hentila J, Shi Y, Ritvos O, et al. Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade. Am J Physiol Endocrinol Metab. 2019;316(5):E852–65.
Thevenot EA, Roux A, Xu Y, Ezan E, Junot C. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. J Proteome Res. 2015;14(8):3322–35.
Xia J, Sinelnikov IV, Han B, Wishart DS. MetaboAnalyst 3.0--making metabolomics more meaningful. Nucleic Acids Res. 2015;43(W1):W251–7.
Xia J, Wishart DS. Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis. Curr Protoc Bioinformatics. 2016;55:14.10.1,14.10.91.
Stephenson EJ, Lessard SJ, Rivas DA, Watt MJ. Yaspelkis BB,3rd, Koch LG, et al. Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab. 2013;305(3):E429–38.
Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, et al. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes. 2015;64(6):2002–14.
Vidal P, Stanford KI. Exercise-induced adaptations to adipose tissue thermogenesis. Front Endocrinol (Lausanne). 2020;11:270.
Argiles JM, Campos N, Lopez-Pedrosa JM, Rueda R, Rodriguez-Manas L. Skeletal muscle regulates metabolism via interorgan crosstalk: roles in health and disease. J Am Med Dir Assoc. 2016;17(9):789–96.
Adeva-Andany MM, Lopez-Maside L, Donapetry-Garcia C, Fernandez-Fernandez C, Sixto-Leal C. Enzymes involved in branched-chain amino acid metabolism in humans. Amino Acids. 2017;49(6):1005–28.
Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7(1):45–56.
Mai M, Tonjes A, Kovacs P, Stumvoll M, Fiedler GM, Leichtle AB. Serum levels of acylcarnitines are altered in prediabetic conditions. PLoS One. 2013;8(12):e82459.
Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, Minkler PE, et al. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr. 2009;139(6):1073–81.
Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, et al. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring). 2010;18(9):1695–700.
She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, et al. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013;8(3):e59443.
Leskinen T, Rinnankoski-Tuikka R, Rintala M, Seppanen-Laakso T, Pollanen E, Alen M, et al. Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLoS One. 2010;5(9). https://doi.org/10.1371/journal.pone.0012609.
Frayn KN, Humphreys SM, Coppack SW. Fuel selection in white adipose tissue. Proc Nutr Soc. 1995 Mar;54(1):177–89.
Elango R. Methionine nutrition and metabolism: insights from animal studies to inform human nutrition. J Nutr. 2020;150(Supplement_1):2518S-23S.
Kouchiwa T, Wada K, Uchiyama M, Kasezawa N, Niisato M, Murakami H, et al. Age-related changes in serum amino acids concentrations in healthy individuals. Clin Chem Lab Med. 2012;50(5):861–70.
Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, et al. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2020;75(10):1805–10.
Mosoni L, Valluy MC, Serrurier B, Prugnaud J, Obled C, Guezennec CY, et al. Altered response of protein synthesis to nutritional state and endurance training in old rats. Am J Phys. 1995;268(2 Pt 1):E328–35.
Timmerman KL, Volpi E. Amino acid metabolism and regulatory effects in aging. Curr Opin Clin Nutr Metab Care. 2008;11(1):45–9.
Koopman R, van Loon LJ. Aging, exercise, and muscle protein metabolism. J Appl Physiol (1985). 2009;106(6):2040–8.
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, et al. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9(5):667–84.
Palmer AK, Kirkland JL. Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol. 2016;86:97–105.
De Carvalho FG, Justice JN, Freitas EC, Kershaw EE, Sparks LM. Adipose tissue quality in aging: how structural and functional aspects of adipose tissue impact skeletal muscle quality. Nutrients. 2019;11(11). https://doi.org/10.3390/nu11112553.
Bremer J. Carnitine--metabolism and functions. Physiol Rev. 1983;63(4):1420–80.
Kokkinos P, Doumas M, Myers J, Faselis C, Manolis A, Pittaras A, et al. A graded association of exercise capacity and all-cause mortality in males with high-normal blood pressure. Blood Press. 2009;18(5):261–7.
Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107(24):3109–16.
Miller VJ, Villamena FA, Volek JS. Nutritional ketosis and mitohormesis: potential implications for mitochondrial function and human health. J Nutr Metab. 2018;2018:5157645.
Miller VJ, LaFountain RA, Barnhart E, Sapper TS, Short J, Arnold WD, et al. A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health. Am J Physiol Endocrinol Metab. 2020;319(6):E995–E1007.