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Body burden of persistent organic pollutants on hypertension: a meta-analysis

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Abstract

Except the known risk factors for hypertension, several studies have suggested that exposure to persistent organic pollutants (POPs), endocrine disrupting chemicals, could be associated with an increased risk of hypertension. In this study, we performed a meta-analysis to summarize the existing epidemiological studies to investigate the association between POPs concentration and risk of hypertension. Based on comprehensive literature search results (PubMed, EMBASE, and KoreaMed), a meta-analysis of 11 articles was performed using a random-effects model. While we observed no significant association between the sum of non-dioxin-like PCBs and the risk of hypertension (OR = 1.00; 95 % CI 0.89, 1.12), the sum of dioxin-like PCBs was associated with a significantly increased risk of hypertension (OR = 1.45; 95 % CI 1.00, 2.12). High p,p′-DDE level was also significantly associated with the increased risk of hypertension. When subgroup analyses were carried out for studies which analyzed POPs concentrations using high-resolution gas chromatography/high-resolution mass spectrometry, the overall pooled estimate ORs increased with decreased heterogeneity, providing it as a possible heterogeneity source (OR = 1.36; 95 % CI 1.21, 1.52; I 2 = 42.8 %; p = 0.045). This study suggested that the concentration of certain POPs, especially dioxin-related compounds, was associated with the risk of hypertension.

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Acknowledgments

This research was supported by a grant (13162MFDS891) from the Ministry of Food and Drug Safety in 2013 and a grant (15162MFDS631) from the Ministry of Food and Drug Safety in 2015.

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    Authors and Affiliations

    1. Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea

      Su Hyun Park & Hyesook Park

    2. Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea

      Jung-eun Lim & Sun Ha Jee

    3. Department of Public Health, Graduate School, Yonsei University, Seoul, Korea

      Jung-eun Lim

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    1. Su Hyun Park
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    Correspondence to Sun Ha Jee.

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    Responsible editor: Hongwen Sun

    Su Hyun Park and Jung-eun Lim contributed equally to this work.

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    Park, S.H., Lim, Je., Park, H. et al. Body burden of persistent organic pollutants on hypertension: a meta-analysis. Environ Sci Pollut Res 23, 14284–14293 (2016). https://doi.org/10.1007/s11356-016-6568-6

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