Abstract
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin American countries and one of the most important fungal diseases regarding incidence and mortality in humans. PCM has also been described in some animal species such as dogs. In this study we describe a new case of PCM disease in a dog that differed from previous records in the literature which includes a progressive evolution of fungal dermatitis causing a deforming lesion in the nose, like those found in human patients, and humoral response against gp70 instead of gp43, the major diagnostic antigen for human PCM. The clinical isolate through the ITS and partial gp43 gene phylogenetic analysis was grouped in the Paracoccidioides brasiliensis complex. This case describes several features which may contribute to improving diagnosis and understanding of canine paracoccidioidomycosis.
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Data availability
Sequence data that support the findings of this study have been deposited in the GenBank database with the accession codes ON746176 and PP475427.
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Acknowledgements
The authors thank Kelvin Shinohata Branco for helping with the phylogenetic analysis, and the dog owners for providing the informed consent for publication of the dog images and clinical data.
Funding
CNPq productivity fellowship granted to Mario Augusto Ono (311922/2018-0) and Ana Paula Frederico Loureiro Bracarense (308136/2018-7).
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I.M.S.S. wrote the manuscript and contributed to mycological and molecular biological studies. F.N. and A.P.F.L.B. contributed to the histopathological analysis and diagnosis. G.G.C.I., R.M. and A.S. contributed to molecular biological studies. B.A.S. and M.L.S.S. contributed to clinical management and patient follow-up. M.A.O. and E.N.I. contributed to manuscript revision and data curation.
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de Souza Suguiura, I.M., Navolar, F.M.N., Souza, B.A. et al. An atypical case of chronic paracoccidioidomycosis in a dog caused by a fungus from the Paracoccidioides brasiliensis complex. Vet Res Commun (2024). https://doi.org/10.1007/s11259-024-10413-0
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DOI: https://doi.org/10.1007/s11259-024-10413-0